GSE125155[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2001251551.

Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

(Submitter supplied) Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its duplication leads to severe neurological conditions as well. Herein, we use the AAV-PHP.eB to deliver an instability-prone Mecp2 (iMecp2) transgene cassette which, increasing RNA destabilization and inefficient protein translation of the viral Mecp2 transgene, limits supraphysiological Mecp2 protein levels. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: TXT

Series

Accession:: GSE125155

ID:: 200125155

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000131122.

Illumina HiSeq 2000 (Mus musculus)

Organism:: Mus musculus

8349 Series
188710 Samples

Platform

Accession:: GPL13112

ID:: 100013112

Select item 3035643363.

Organism:: Mus musculus

Source name:: KO-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564336

ID:: 303564336

SRA Run Selector

Select item 3035643354.

Organism:: Mus musculus

Source name:: KO-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564335

ID:: 303564335

SRA Run Selector

Select item 3035643345.

Organism:: Mus musculus

Source name:: KO-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564334

ID:: 303564334

SRA Run Selector

Select item 3035643336.

Organism:: Mus musculus

Source name:: KO cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564333

ID:: 303564333

SRA Run Selector

Select item 3035643327.

Organism:: Mus musculus

Source name:: KO cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564332

ID:: 303564332

SRA Run Selector

Select item 3035643318.

Organism:: Mus musculus

Source name:: KO cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564331

ID:: 303564331

SRA Run Selector

Select item 3035643309.

Organism:: Mus musculus

Source name:: WT-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564330

ID:: 303564330

SRA Run Selector

Select item 30356432910.

Organism:: Mus musculus

Source name:: WT-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564329

ID:: 303564329

SRA Run Selector

Select item 30356432811.

Organism:: Mus musculus

Source name:: WT-GT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564328

ID:: 303564328

SRA Run Selector

Select item 30356432712.

Organism:: Mus musculus

Source name:: WT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564327

ID:: 303564327

SRA Run Selector

Select item 30356432613.

Organism:: Mus musculus

Source name:: WT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564326

ID:: 303564326

SRA Run Selector

Select item 30356432514.

Organism:: Mus musculus

Source name:: WT cortex

Platform:: GPL13112
Series:: GSE125155

Download data: TXT

Sample

Accession:: GSM3564325

ID:: 303564325

SRA Run Selector

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