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Items: 6

1.

Dynamic behavior of the epigenetic machinery upon thermal stress

(Submitter supplied) Maintenance of the epigenome is of utmost importance to warrant appropriate cellular functioning Here we analyzed PRC1/2 function, in response to cellular stress. We observe that heat shock (HS) leads to nucleolar accumulation of CBX proteins, and are strongly immobilized in a 1,6-hexanediol insensitive manner, suggestive of a HS-induced liquid-to-solid phase transition of the nucleolus. CBX protein recovery from the nucleolus is dependent on heat shock protein (HSP) activity. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: BW
Series
Accession:
GSE121182
ID:
200121182
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

GFP-CBX2-HS

Organism:
Homo sapiens
Source name:
K562
Platform:
GPL18573
Series:
GSE121182
Download data: BW
Sample
Accession:
GSM3427441
ID:
303427441
4.

GFP-CBX2-untreated

Organism:
Homo sapiens
Source name:
K562
Platform:
GPL18573
Series:
GSE121182
Download data: BW
Sample
Accession:
GSM3427440
ID:
303427440
5.

CBX8-HS

Organism:
Homo sapiens
Source name:
K562
Platform:
GPL18573
Series:
GSE121182
Download data: BW
Sample
Accession:
GSM3427439
ID:
303427439
6.

CBX8-untreated

Organism:
Homo sapiens
Source name:
K562
Platform:
GPL18573
Series:
GSE121182
Download data: BW
Sample
Accession:
GSM3427438
ID:
303427438
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Supplemental Content

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