GSE107705[Accession] - GEO DataSets - NCBI

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iRhom2 Promotes Lupus Nephritis through ADAM17-Dependent TNF-α and EGFR Signaling

(Submitter supplied) Lupus nephritis (LN) often results in progressive renal dysfunction. The inactive Rhomboid 2 (iRhom2) is a newly identified key regulator of A disintegrin and metalloprotease 17 (ADAM17), whose substrates, such as TNF-α and heparin-binding EGF (HB-EGF), have been implicated in the pathogenesis of chronic kidney disease. Here we demonstrate that deficiency of iRhom2 protects the lupus-prone Fcgr2b-/- mice from developing severe kidney damage without altering anti-double stranded (ds) DNA Ab production, by simultaneously blocking the HB-EGF/EGFR and the TNF-α signaling in the kidney tissues. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
28 Samples

Download data: CSV

Series

Accession:: GSE107705

ID:: 200107705

SRA Run Selector

Select item 1000170212.

Illumina HiSeq 2500 (Mus musculus)

Organism:: Mus musculus

11109 Series
299307 Samples

Platform

Accession:: GPL17021

ID:: 100017021

Select item 3028762853.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876285

ID:: 302876285

SRA Run Selector

Select item 3028762844.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876284

ID:: 302876284

SRA Run Selector

Select item 3028762835.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876283

ID:: 302876283

SRA Run Selector

Select item 3028762826.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876282

ID:: 302876282

SRA Run Selector

Select item 3028762817.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876281

ID:: 302876281

SRA Run Selector

Select item 3028762808.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876280

ID:: 302876280

SRA Run Selector

Select item 3028762799.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876279

ID:: 302876279

SRA Run Selector

Select item 30287627810.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876278

ID:: 302876278

SRA Run Selector

Select item 30287627711.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876277

ID:: 302876277

SRA Run Selector

Select item 30287627612.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876276

ID:: 302876276

SRA Run Selector

Select item 30287627513.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876275

ID:: 302876275

SRA Run Selector

Select item 30287627414.

Organism:: Mus musculus

Source name:: sorted kidney macrophages

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876274

ID:: 302876274

SRA Run Selector

Select item 30287627315.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876273

ID:: 302876273

SRA Run Selector

Select item 30287627216.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876272

ID:: 302876272

SRA Run Selector

Select item 30287627117.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876271

ID:: 302876271

SRA Run Selector

Select item 30287627018.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876270

ID:: 302876270

SRA Run Selector

Select item 30287626919.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876269

ID:: 302876269

SRA Run Selector

Select item 30287626820.

Organism:: Mus musculus

Source name:: total kidney

Platform:: GPL17021
Series:: GSE107705

Sample

Accession:: GSM2876268

ID:: 302876268

SRA Run Selector

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