GPL6947[RGSE] - GEO DataSets - NCBI

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Select item 2000675181.

Rosiglitazone-targeted transcriptional networks as gene expression signature of physiological and pathological mineralization

(Submitter supplied) Rosiglitazone-targeted transcriptional networks as gene expression signature of physiological and pathological mineralization – a top-down approach to identify novel targets for bone and vascular health Clinical studies have recently revealed detrimental skeletal and vascular effects of the insulin sensitizer rosiglitazone. At the cellular level, we have shown earlier that rosiglitazone accelerates osteoblast differentiation from human mesenchymal stem cells (hMSC) at the expense of increased oxidative stress and apoptosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
12 Samples

Download data: TXT

Series

Accession:: GSE67518

ID:: 200067518

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002000022.

Fibroblast heterogeneity: a new phenotype associated with photoaging/solar elastosis

(Submitter supplied) We here present a novel subtype of fibroblasts isolated from sun-exposed skin of elderly donors and characterized by its prominent and stable myo-chondrocyte-type differentiation. As we depict a similar chondrocyte-type expression pattern at sites of solar elastosis in human skin, we propose that this fibroblasts phenotype develops in the course of massive and perseverative UV-dependent damage as part of the process terminating in the most severe appearance of photoaging - solar elastosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6947 GPL10558
24 Samples

Download data: IDAT, TXT

Series

Accession:: GSE200002

ID:: 200200002

Analyze with GEO2R

Select item 2001471633.

Molecular subtypes in gastric cancer. [III]

(Submitter supplied) We identified the molecular subtypes and conserved modules in gastric cancer by unsupervised clustering algorithm. We defined six molecular signatrues of gastric cancer associated with the biological heterogeneity of gastric cancer and clinical outcome of patients.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
50 Samples

Download data: IDAT, TXT

Series

Accession:: GSE147163

ID:: 200147163

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000520604.

Expression of the MET oncogene correlates with upregulation of coagulation factor XII and procoagulant disorders in colorectal cancer

(Submitter supplied) Cancer patients often develop hemostasis disorders whose pathogenesis is poorly understood. Previous work in mouse models has shown that these disorders can be sustained by the MET oncogene by transcriptional upregulation of hemostasis genes. Here we investigated the correlation between the procoagulant state of colorectal cancer patients, and overexpression of MET and hemostasis genes in the tumor. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
46 Samples

Download data: TXT

Series

Accession:: GSE52060

ID:: 200052060

Analyze with GEO2R

Select item 2001913025.

Transcriptome and proteome analysis in LUHMES cells overexpressing alpha-synuclein

(Submitter supplied) Differential transcriptome analysis in LUHMES cells overexpressing human wild-type alpha-synuclein or GFP

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
6 Samples

Download data: IDAT, TXT

Series

Accession:: GSE191302

ID:: 200191302

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001831366.

Development and Validation of a Prognostic and Predictive 32-Gene Signature for Gastric Cancer

(Submitter supplied) Genomic profiling can provide prognostic and predictive information to guide clinical care. Biomarkers that reliably predict patient response to chemotherapy and immune checkpoint inhibition in gastric cancer are lacking. In this retrospective analysis, we use our machine learning algorithm NTriPath [Park, Sunho et al. “An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types.” Bioinformatics (2016): 1643-51. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
135 Samples

Download data: TXT

Series

Accession:: GSE183136

ID:: 200183136

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001638837.

TGFβ/Cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity

(Submitter supplied) To understand the mechanism by which TGFβ regulates tumor initiation in triple negative breast cancer (TNBC), we performed microarray analysis using Illumina Human HT-12 Gene Expression BeadChip. A TNBC cell line of SCP2 was treated or not with TGFβ for 24 hours. Differentially expressed genes were analyzed by comparing treated versus non-treated samples

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
4 Samples

Download data: TXT

Series

Accession:: GSE163883

ID:: 200163883

Analyze with GEO2R

Select item 2000260678.

Gene expression profiling of Huh7 and THP1 cells after siRNA knockdown of C5/TRAF1 intergenic transcript

(Submitter supplied) The C5/TRAF1 locus is a well validated genetic risk factor for RA. Upon further investigation of this region we recently discovered that the intergenic region between these two immune-related genes is activelly transcribed in a variety of tissues and is up-regulated in PBMCs, monocytes, B- and T-cells upon immune stimulation. The present study aimed to characterize the biological function of this newly identified C5/TRAF1 intergenic transcript, by analysing the effect of its knockdow on the gene expression profiles of Huh7 and THP1 cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
48 Samples

Download data: TXT

Series

Accession:: GSE26067

ID:: 200026067

Analyze with GEO2R

Select item 2000370139.

Genome-wide analysis of Ischaemia-Reperfusion damage in human bowel

(Submitter supplied) Comprehensive understanding of the transcriptional foundations of human intestinal ischemia-reperfusion (IR) injury is imperative to find therapeutic targets and improve patient outcome. Here we analysed transcriptomes of the IR-injured human intestine, and showed that over 1,800 genes were significantly differentially expressed, predominantly during reperfusion. Intriguingly, protein processing in endoplasmic reticulum (ER) was one of the most perturbed pathways, which was supported by ontology analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
28 Samples

Download data: TXT

Series

Accession:: GSE37013

ID:: 200037013

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014448910.

Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation

(Submitter supplied) Genome-wide methods for examining chromatin modification provide detailed information on regulatory regions of the genome. Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through direct signalling pathway-mediated transcription factor activation and regulatory element binding.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
6 Samples

Download data: TXT

Series

Accession:: GSE144489

ID:: 200144489

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005571511.

Gene expression patterns of a novel breast cancer cell line derived from a bone metastatic lesion of a breast cancer patient

(Submitter supplied) As organ-specific models of breast cancer bone metastasis do not exist, we established a novel breast cancer line was established from the ER-/PR-/HER2- bone metastasis from a breast cancer patient. This cell line was characterized and compared to the primary tumour and/or normal mammary epithelial cells with regards to phenotypes (i.e. marker expression), gene expression and copy number variation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
8 Samples

Download data: TXT

Series

Accession:: GSE55715

ID:: 200055715

PubMed Similar studies Analyze with GEO2R

Select item 20002555512.

Effect of Spag4 knockdown in 293T cells

(Submitter supplied) To test the effect of Spag4 knockdown, we compared knockdown and control cells subjected to 48h 2uM camptothecin treatment or vehicle.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
12 Samples

Download data: TXT

Series

Accession:: GSE25555

ID:: 200025555

Analyze with GEO2R

Select item 20003085413.

Fecal microbial infusion from lean donors increases insulin sensitivity in subjects with metabolic syndrome

(Submitter supplied) Alterations in intestinal microbiota and intestinal short chain fatty acids profiles have been associated with the pathophysiology of obesity and insulin resistance. Whether intestinal microbiota dysbiosis is a causative factor in humans remains to be clarified We examined the effect of fecal microbial infusion from lean donors on the intestinal microbiota composition, glucose metabolism and small intestinal gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
46 Samples

Download data: TXT

Series

Accession:: GSE30854

ID:: 200030854

PubMed Similar studies Analyze with GEO2R

Select item 20014636114.

Gene expression profiling of 27 gastric cancer cell lines

(Submitter supplied) We identified molecular subtypes of 27 gastric cancer cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
108 Samples

Download data: IDAT, TXT

Series

Accession:: GSE146361

ID:: 200146361

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013176915.

Genomic signature of the standardized uptake value in 18F-fluorodeoxyglucose positron emission tomography in breast cancer

(Submitter supplied) The standardized uptake value (SUV), an indicator of the glucose uptake degree in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used as a prognostic factor in malignant tumors. We aimed to identify a signature reflecting prognostic SUV characteristics in breast cancer (BRC). Transcriptome profiling was performed to identify a signature associated with the SUV in BRC patients who underwent preoperative FDG-PET. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
301 Samples

Download data: TXT

Series

Accession:: GSE131769

ID:: 200131769

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014687016.

Recurring urothelial carcinomas show genomic rearrangements incompatible with a direct relationship, implications for tumor development.

(Submitter supplied) We made use of the fact that patients with non-muscle invasive tumors show frequent local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may appear abruptly and disappear with no transitional stages being observed. By analysis of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient show such changes, thus the tumors cannot have originated from each other. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL6947 GPL10558
47 Samples

Download data: TXT

Series

Accession:: GSE146870

ID:: 200146870

PubMed Full text in PMC Similar studies

Select item 20013167917.

Genome-wide analysis of human monocytes cultured on wt- LX2 or CD44 ko LX2

(Submitter supplied) Analyis of the induction of myeloid derived suppressor cells using the LX2 model

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
6 Samples

Download data: TXT

Series

Accession:: GSE131679

ID:: 200131679

PubMed Similar studies Analyze with GEO2R

Select item 20003710718.

Genome-wide transcription analysis of whole blood prior to rituximab treatment in relation to clinical response

(Submitter supplied) B cell depletion therapy is efficacious in RA patients failing on TNF blocking agents. However, approximately 40-50% of the rituximab-treated RA patients have a poor response. We investigated wheter baseline gene expression levels can discriminate between clinical nonresponders and responders to rituximab

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
14 Samples

Download data: TXT

Series

Accession:: GSE37107

ID:: 200037107

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011804019.

Gene expression profiling comparing myeloma cell line MM1.144 transduced with a scramble shRNA or an shRNA targeting the non-canonical WNT receptor ROR2

(Submitter supplied) We examined the gene expression profiles resulting from the depletion of the non-canonical WNT receptor ROR2 in myeloma cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
10 Samples

Download data: TXT

Series

Accession:: GSE118040

ID:: 200118040

PubMed Similar studies Analyze with GEO2R

Select item 20008035520.

Genome-wide analysis of impact of culture conditions on gene expression of primary leukemic cells from chronic lymphocytic leukemia (CLL)

(Submitter supplied) Proliferation and survival of CLL cells is highly dependent on the interaction of the tumor cells with different populations of accessory cells, incl. mesenchymal bone marrow stromal cells. In this project interactions between CLL cells and transformed bone-marrow derived fibroblast cell lines were studied. Gene expression was analyzed in CLL cells that were cocultured for different time periods with human (HS-5) or murine (M2-10B4) transformed fibroblasts, as compared to CLL cells from the same patient sample that were cultured in DMEM medium or conditioned medium in which HS-5 cells had been growing.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6947 GPL6884
44 Samples

Download data: TXT

Series

Accession:: GSE80355

ID:: 200080355

PubMed Similar studies Analyze with GEO2R

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GPL6947[RGSE] (542)
GEO DataSets
RecName: Full=Transcription factor LBX2; AltName: Full=Ladybird homeobox 2; AltN...
RecName: Full=Transcription factor LBX2; AltName: Full=Ladybird homeobox 2; AltName: Full=Ladybird homeobox protein homolog 2
gi|74749508|sp|Q6XYB7.1|LBX2_HUMAN

Protein
Sodium-Phosphate Cotransporter Proteins, Type IIa
Sodium-Phosphate Cotransporter Proteins, Type IIa
An electrogenic sodium-dependent phosphate transporter. It is present primarily in BRUSH BORDER membranes of PROXIMAL RENAL TUBULES.<br/>Year introduced: 2006(2004)

MeSH
Glutamate Plasma Membrane Transport Proteins
Glutamate Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM io...<br/>Year introduced: 2006(1984)

MeSH
Dopamine Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by hi...<br/>Year introduced: 2006(1987)

MeSH

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