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Items: 1 to 20 of 16196

1.

Pathways Related to NLRP3 Inflammasome Activation Induced by Gold Nanorods

(Submitter supplied) The immune system may respond to engineered nanomaterials (ENM) through inflammatory reactions. The NLRP3 inflammasome responds to a wide range of ENM, and its activation is associated with various inflammatory diseases. The objective of the study was to compare the effects of gold ENM of different shapes on NLRP3 inflammasome activation and related signalling pathways. Differentiated THP-1 cells (wildtype, ASC- or NLRP3-deficient), were exposed to PEGylated gold nanorods, nanostars, and nanospheres. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
24 Samples
Download data: TXT
Series
Accession:
GSE233641
ID:
200233641
2.

Comparison of Vdelta1 and Vdelta2 cells

(Submitter supplied) Gene expression analysis comparison of ex vivo isolated GD T cell subpopulations Under non-pathological conditions, human gd T cells represent a small fraction of CD3+ T cells in peripheral blood (1-10%). They constitute a unique subset of T lymphocytes that recognize stress ligands or non-peptide antigens through MHC-independent presentation. Major human gd T cell subsets, Vd1 and Vd2, expand in response to microbial infection or malignancy, but possess distinct tissue localization, antigen recognition, and effector responses. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
8 Samples
Download data: TXT
Series
Accession:
GSE224362
ID:
200224362
3.

Human neutrophils stimulated with IL-13.

(Submitter supplied) Studying the effect of Th2 cytokine IL13 on on gene expression of human neutrophils by comparing gene expression of neutrophiles isolated from the blood of 3 healthy donors and stimulated with IL-13 (10ng/ml) or left unstimulated.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE135426
ID:
200135426
4.

Human neutrophils stimulated with IFNg.

(Submitter supplied) Studying the effect of Th1 cytokine IFNg on gene expression of human neutrophils by comparing gene expression of neutrophiles isolated from the blood of 3 healthy donors and stimulated with IFNg (10ng/ml) or left unstimulated.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE135425
ID:
200135425
5.

Human neutrophils stimulated with IL-4.

(Submitter supplied) Studying the effect of Th2 cytokine IL4 on gene expression of human neutrophils by comparing gene expression of neutrophils isolated from the blood of 3 healthy donors and stimulated with IL-4 (1ng/ml) or left unstimulated.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE135421
ID:
200135421
6.

The Adult T-Cell Leukemia/Lymphoma Cell Line KK1 +/- RhoH Reconstitution

(Submitter supplied) The adult T-cell leukemia/lymphoma cell line KK1 with low RhoH expression was stably transfected with either an empty expression vector or this same vector expressing human RhoH. The transcriptomes of these two daughter lines were then compared by differential microarray analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
4 Samples
Download data: TXT
Series
Accession:
GSE228059
ID:
200228059
7.

Microarray analyses of mRNA in PCDH1 knockdown cells

(Submitter supplied) Uncontrolled growth, distant metastasis and chemoresistance are critical characteristics of pancreatic ductal adenocarcinoma (PDAC). We identified PCDH1 acting as a novel prognostic marker for PDAC. PCDH1 enhanced p65 nuclear localization by interacting with KPNB1, therefore activates NF-κB signaling pathway and function during the progression of PDAC.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE201971
ID:
200201971
8.

Dual functions of NEIL3 in DNA repair and the epithelial-mesenchymal transition

(Submitter supplied) Twelve pairs of tumorous and peritumorous liver tissues (6 HBV- and 6 HCV-related HCC) that were obtained during the surgical liver resection of HCC patients were subjected to cDNA microarray analysis (Agilent Human Gene Expression v2 4x44K Microarray Kit) to screen the genes with expression levels that were different in the tumor than they were in the peritumorous tissue.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
24 Samples
Download data: TXT
Series
Accession:
GSE147888
ID:
200147888
9.

Myxoid liposarcoma tumor gene expression by array analysis

(Submitter supplied) Gene expression analysis of myxoid liposarcoma (MLS) tumors from five different patients
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
5 Samples
Download data: TXT
Series
Accession:
GSE167270
ID:
200167270
10.

Characterization of Richter Syndrome cell line U-RT1

(Submitter supplied) mRNA profiling of the Richter Syndrome cell line U-RT1. The expression profiles were compared to published expression profiles of different diffuse large B cell lymphoma cell lines (Array Express E MTAB-973 and GEO Accession Number GSM466597) to determine whether there are differences in expression that indicate differences on molecular grounds.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
3 Samples
Download data: TXT, XLSX
Series
Accession:
GSE171481
ID:
200171481
11.

Epstein-Barr Virus Nuclear Antigen 1 (EBNA1)

(Submitter supplied) Expression of mRNAs in EBV-positive B-cell strains in the presence or absence of EBNA1 or a mutant of EBNA1 (ΔUR1-EBNA) that is unable to activate transcription.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
15 Samples
Download data: TXT
Series
Accession:
GSE75198
ID:
200075198
12.

Transcriptomics analysis and redox-dependent metabolic rewiring in triple-negative breast cancer cells

(Submitter supplied) Glucose metabolism toward aerobic glycolysis provides cancer cells with a rapid generation of pyruvate, ATP, and NADH. CtPB2, an NADH-dependent transcriptional co-regulator, has been proposed to work as an NADH sensor, linking metabolism to transcriptional reprogramming. Here we described how the down-regulation of CtBP2 strongly reduces cell proliferation in triple negative breast cancer (BC) cell line, by modulating several intracellular pathways also through gene expression modification. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
15 Samples
Download data: TXT
Series
Accession:
GSE178748
ID:
200178748
13.

Expression profiles of epicardial and subcutaneous adipose tissue

(Submitter supplied) The epicardial adipose tissue (EAT) is a visceral adipose tissue in close contact with coronary vessels whose increase is associated with coronary artery disease (CAD). Our goal was to identify candidate molecule(s) characterizing EAT which could intervene in the pathogenesis of CAD. An approach combining microarrays and bioinformatic sequence analysis tools for predicting secreted proteins (TargetP) was applied to paired biopsies of subcutaneous adipose tissue (SAT) and EAT, obtained from patients with or without CAD (NCAD). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
13 Samples
Download data: GPR
Series
Accession:
GSE18612
ID:
200018612
14.

A transcriptomic analysis of primary fibroblasts isolated from young donors identifies a subset of donors displaying features of early senescence

(Submitter supplied) Even though its development starts early in utero, neonatal skin is still immature at birth relative to adult and undergoes a maturation process extending to the first years of life. It is now established that stratum corneum is thinner and dryer, and that skin contains less natural moisturizing factors and lipids in newborns compared to children and adults. Moreover, it has been shown that skin surface area expansion is not linear throughout life and is peaking perinatally, suggesting that baby skin has a higher epidermal cellular turnover. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
9 Samples
Download data: TXT
Series
Accession:
GSE185679
ID:
200185679
15.

Claudin-7 in keratinocytes is downregulated by the inhibition of HMG-CoA reductase and is highly expressed in the stratum granulosum of the psoriatic epidermis

(Submitter supplied) Background: Cholesterol is de novo synthesized in the upper epidermis and plays an important role in maintaining the normality of skin. Studying the impact of the inhibition of cholesterol de novo synthesis in the epidermis may help understand how skin homeostasis is regulated. Objective: In this study, we created a gene expression profile to investigate the effect of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors on epidermal homeostasis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
4 Samples
Download data: TXT
Series
Accession:
GSE180418
ID:
200180418
16.

Microarray analysis of U87 Glioblastoma Multiforme cell line exposed to proton irradiation during acute hypoxia.

(Submitter supplied) Glioblastoma multiforme (GBM), is the most malignant and common tumor among glial neoplasms. It is characterized by a peak of incidence between 45 and 70 years and a patient median survival time of 14.6 months. In addition, GBM undergoes malignant progression under hypoxic conditions that contributes to strong radioresistance and chemoresistance; alters the metabolism of the tumor cells; generates a strong genome instability, increases the angiogenesis, vasculogenesis, and contributes to the formation of the Cancer Stem Cells (CSCs) and the infamous Circulating Tumor Cells (CTCs) involved in metastasis formation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
12 Samples
Download data: TXT
Series
Accession:
GSE162986
ID:
200162986
17.

GEP signatures of primary breast cells radiation treated.

(Submitter supplied) Breast cancer (BC) recovery has considerably increased thanks to the advances achieved from research in this field. However, despite the important results obtained, BC remains a complex multifactorial disease with distinct subtypes associated with different outcomes.So, many efforts from radiobiological research are needed to help clinicians in understanding molecular features of a specific tumor subtype, in order to better define the most successful treatment plan, including the choice of the best Radiation Teraphy (RT) modality and schedule in clinical practice. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
36 Samples
Download data: TXT
Series
Accession:
GSE110933
ID:
200110933
18.

Transcriptomic analysis of HCT116 cells cultured under different oxygen conditions

(Submitter supplied) To explore the molecular basis of hypoxic response, we analyzed gene expression profiles of HCT116 cells cultured under different oxygen conditions with or without inhibition of P53 signaling or fatty acid b oxidation (FAO).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL13607 GPL4133
16 Samples
Download data: TXT
Series
Accession:
GSE109318
ID:
200109318
19.

Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPIs) - targeted therapy

(Submitter supplied) Epithelial ovarian cancer (EOC) is the most serious of all gynecological cancers, mainly due to its asymptomatic nature and the resulting lack of early diagnosis. Cells with defects in DNA repair accumulate genetic abnormalities and may progress to become malignant. However, this DNA repair deficiency makes tumor cells vulnerable to further compromise by therapeutic targeting of other associated pathways, using agents such as poly-ADP ribose polymerase (PARP) inhibitors (PARPIs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
12 Samples
Download data: TXT
Series
Accession:
GSE149940
ID:
200149940
20.

Relationship between insulin sensitivity and gene expression in human skeletal muscle

(Submitter supplied) The aim of this study was therefore to investigate molecular mechanisms associated with insulin sensitivity in skeletal muscle by relating global skeletal muscle gene expression with a surrogate measure of insulin sensitivity, i.e. homeostatic model assessment of insulin resistance (HOMA-IR). To identify genes with skeletal muscle expression related to insulin sensitivity, we obtained muscle biopsies from 38 non-diabetic participants in study A. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL7144 GPL4133
47 Samples
Download data: CEL, TXT
Series
Accession:
GSE161721
ID:
200161721
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