GEO DataSets

(Submitter supplied) Bats harbour various viruses without severe symptoms and act as natural reservoirs. This tolerance of bats toward viral infections is assumed to be originated from the uniqueness of their immune system. However, how the innate immune response varies between primates and bats remains unclear. To illuminate differences in innate immune responses among animal species, we performed a comparative single-cell RNA-sequencing analysis on peripheral blood mononuclear cells (PBMCs) from four species including Egyptian fruit bats inoculated with various infectious stimuli.

Organism:

Pan troglodytes; Rousettus aegyptiacus; Macaca mulatta; Homo sapiens

Type:

Expression profiling by high throughput sequencing

4 related Platforms

16 Samples

Download data: H5

(Submitter supplied) Bats harbor high-impact zoonotic viruses in absence of clinical disease, which has been recently associated with unique features of their immune system. They seem to restrict inflammation and possibly limit disease manifestation to a minimum. In-depth characterization of cellular immunity in bats is yet largely missing, and imprinting of age and development on immune cell compartments remains unexplored. more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30616

4 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) This represents the first transcriptomic and epigenomic characterization of the vocalization-associated brain circuits of a non-human mammalian vocal learner (Egyptian fruit bat), yielding fundamental insights into the regulatory and molecular pathways underlying the evolution of complex vocal behavior in mammals.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL30616

32 Samples

Download data: BIGWIG, NARROWPEAK, SF