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Chromatin and siRNA pathways cooperate to maintain DNA methylation

(Submitter supplied) DNA methylation occurs at preferred sites in eukaryotes, although the basis for preference is not known. We use a microarray-based profiling method to explore the involvement of Arabidopsis CMT3 and DRM DNA methyltransferases, a histone H3 lysine-9 methyltransferase (KYP) and an Argonaute-related RNA silencing component (AGO4) in methylating target loci. We find that KYP targets are also CMT3 targets, suggesting that histone methylation maintains CNG methylation genome-wide. more...
Organism:
Arabidopsis thaliana
Type:
Methylation profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL1911 GPL2726
60 Samples
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Series
Accession:
GSE3109
ID:
200003109

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