GPL2616[RGSE] - GEO DataSets

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Items: 13

Select item 2000190341.

EYA4 is a non-small cell lung cancer tumor suppressor located in the susceptibility locus on chromosome 6q

(Submitter supplied) This study was undertaken to identify novel tumour suppressor genes in lung adenocarcinoma. EYA4, located at 6q23.2 was identified as a frequently lost and hypermethylated gene in the analyzed samples. EYA4 is underexpressed in addition to being deleted and hypermethylated. Control of EYA4 expression by DNA methylation was assessed using 5'-azacytidine. The role of EYA4 in apoptosis was assessed using a stable knock down of the gene which was assessed for apoptotis using FACS and qPCR.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL8490 GPL2616
90 Samples

Download data: IDAT, TXT

Series

Accession:: GSE19034

ID:: 200019034

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Select item 2000411202.

Molecular Characterization of 126 Intermediate Risk Prostate Cancer Patient Samples

(Submitter supplied) The primary objective of this study was to correlate genetic alterations from Hh pathway genes with biochemical free relapse rate.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
126 Samples

Download data: CSV, TXT

Series

Accession:: GSE41120

ID:: 200041120

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000215413.

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis; Methylation profiling by array; SNP genotyping by SNP array; Genome variation profiling by genome tiling array

5 related Platforms
45 Samples

Download data: CEL, IDAT, TXT

Series

Accession:: GSE21541

ID:: 200021541

PubMed Full text in PMC Similar studies

Select item 2000215404.

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer: CGH

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
7 Samples

Download data: TXT

Series

Accession:: GSE21540

ID:: 200021540

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000133315.

Prognostic analysis of mantle cell lymphoma genomes

(Submitter supplied) Mantle cell lymphoma is characterized by a t(11;14) chromosomal translocation; however, it alone is insufficient to result in the disease. A number of secondary genetic alterations have been proposed as essential in MCL pathogenesis. Amongst these, numerous copy number altered regions remain ill-defined, both for location and prognostic significance. In this study we examined in detail the genomes of a panel of 52 MCL cases. more...

Organism:: Homo sapiens

Type:: Expression profiling by SAGE; Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL2616 GPL4544 GPL1485
57 Samples

Download data: TXT

Series

Accession:: GSE13331

ID:: 200013331

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Select item 2000112756.

Tiling-set aCGH data for oral dysplasias and oral squamous cell carcinomas

(Submitter supplied) Analysis of DNA from 89 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL2616 GPL2043
86 Samples

Download data: TXT

Series

Accession:: GSE11275

ID:: 200011275

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000091937.

Oral dysplasias and oral squamous cell carcinoma

(Submitter supplied) Analysis of DNA from 94 oral lesions by whole genome tiling-path array comparative genomic hybridization. Keywords: array comparative genomic hybridization

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL2043 GPL2616
94 Samples

Download data: TXT

Series

Accession:: GSE9193

ID:: 200009193

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000123938.

Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization

(Submitter supplied) The secondary genetic events associated with follicular lymphoma (FL) progression are not well defined. We applied genome-wide BAC array comparative genomic hybridization to 106 diagnostic biopsies of FL to characterize regional genomic imbalances. Using an analytical approach that defined regions of copy number change as intersections between visual annotations and a Hidden Markov model-based algorithm, we identified 71 regional alterations that were recurrent in ≥10% of cases. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
106 Samples

Download data: TXT

Series

Accession:: GSE12393

ID:: 200012393

Select item 2000119459.

Genomic markers for malignant progression in pulmonary adenocarcinoma.

(Submitter supplied) Bronchioloalveolar carcinoma (BAC), a subtype of lung adenocarcinoma (ADC) without stromal, vascular, or pleural invasion, is considered an in situ tumor with a 100% survival rate. However, the histological criteria for invasion remain controversial. BAC-like areas may accompany otherwise invasive adenocarcinoma, referred to as mixed type adenocarcinoma with BAC features (AWBF). AWBF are considered to evolve from BAC, representing a paradigm for malignant progression in ADC. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
29 Samples

Download data: TXT

Series

Accession:: GSE11945

ID:: 200011945

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000504910.

Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cells

(Submitter supplied) Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease suggesting that additional host genetic alterations are necessary for disease progression. In this study we examined the genomes of a panel of commonly used model cervical cancer cell lines using a recently developed whole genome tiling path array for CGH analysis. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
8 Samples

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Series

Accession:: GSE5049

ID:: 200005049

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Select item 20000544211.

A comprehensive analysis of copy number variations in the human genome

(Submitter supplied) Segmental copy number variations (CNVs) in the human genome are associated with developmental disorders and susceptibility to human diseases. More importantly, these variations may represent a major genetic component of our phenotypic diversity. In this study, using a whole genome array CGH assay, we identified 3,654 autosomal segmental CNVs, of which 800 appeared at a frequency of at least 3%. 77% of these frequent CNVs are novel. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL2616 GPL4056
150 Samples

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Series

Accession:: GSE5442

ID:: 200005442

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000459112.

High resolution analysis of early lobular neoplastic breast lesions (ALH and LCIS) by whole genome tiling path array CGH

(Submitter supplied) The identification of genomic alterations occurring in neoplastic lesions provides insight into both lesion occurrence and disease progression. In this study we used microarray comparative genomic hybridization (CGH) to investigate genetic changes in atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS), as the presence of these lobular neoplastic lesions is an indicator of risk in the development of invasive breast cancer. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL2616
25 Samples

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Series

Accession:: GSE4591

ID:: 200004591

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Select item 20000292213.

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH

(Submitter supplied) Chromosomal regions harboring tumor suppressors and oncogenes are often deleted or amplified. Array comparative genomic hybridization (CGH) detects segmental DNA copy number alterations in tumor DNA relative to a normal control. The recent development of a bacterial artificial chromosome (BAC) array, that spans the human genome in a tiling path manner with >32,000 clones, has facilitated whole genome profiling at an unprecedented resolution. more...