bursa sodiroi - GEO DataSets

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Select item 2002769541.

A single-nucleus census of immune and non-immune cell types for the major immune organ systems of chicken

(Submitter supplied) In the avian host, comprehensively cataloging immune cell types, their transcriptome profiles, and varying molecular responses to pathogen challenges are necessary steps toward a better understanding of the interplay between genetics and disease resilience. We present a first nuclei atlas of immune cell types derived from the three main immune organs of layer chickens, including spleen, bursa, and thymus. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
2 Samples

Download data: H5

Series

Accession:: GSE276954

ID:: 200276954

Select item 2002464682.

Dosage sensitive maternal siRNAs determine hybridization success in Capsella

(Submitter supplied) Hybrid seed failure arising from wide crosses between plant species is a recurring obstacle in plant breeding, impeding the transfer of desirable traits. This postzygotic reproductive barrier primarily occurs in the endosperm, a dosage-sensitive tissue that nurtures the embryo and functions analogously to the placenta in mammals. Here, we show that the endosperm in incompatible seeds loses DNA methylation and chromatin condensation, resembling the endosperm of seeds depleted for maternal RNA Polymerase IV (PolIV) function. more...

Organism:: Capsella grandiflora x Capsella rubella; Capsella bursa-pastoris; Capsella rubella; Capsella rubella x Capsella grandiflora; Capsella grandiflora; Capsella orientalis; Capsella orientalis x Capsella rubella; Capsella bursa-pastoris x Capsella grandiflora

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

8 related Platforms
81 Samples

Download data: TXT

Series

Accession:: GSE246468

ID:: 200246468

Select item 2002496523.

Host transcriptomic response to a bacterial toxin at single-nuclei resolution

(Submitter supplied) We are studying the host immune response to a bacterial toxin in the chicken spleen and bursa. We performed snRNAseq to analyze the various immune cell types that play a role in combating the infection and the cell-type transcriptional response.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
10 Samples

Download data: MTX, TSV

Series

Accession:: GSE249652

ID:: 200249652

Select item 2002546594.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [NG-Capture-C]

(Submitter supplied) Three-dimensional organization of mitotic chromosomes is established by cohesin and condensin complexes. In the centromere, cohesin maintains sister chromatid pairing until anaphase onset, while condensin provides elastic resistance to spindle forces. However, how condensin and cohesin structure vertebrate centromeres remains unclear. By super-resolution imaging, Capture-C analysis and polymer modeling we show that vertebrate centromeres are partitioned into two condensin-dependent subdomains during mitosis. more...

Organism:: Gallus gallus

Type:: Other

Platforms:: GPL26853 GPL19005
60 Samples

Download data: BEDGRAPH

Series

Accession:: GSE254659

ID:: 200254659

Select item 2002541825.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL32831 GPL19005 GPL26853
100 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE254182

ID:: 200254182

Select item 2002541816.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [CENPA-ChIP-seq]

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL26853 GPL19005
8 Samples

Download data: BW

Series

Accession:: GSE254181

ID:: 200254181

Select item 2002541807.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [Halo-ChIP-seq]

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL32831
32 Samples

Download data: BW

Series

Accession:: GSE254180

ID:: 200254180

Select item 2002167938.

Spatial extracellular vesicle microRNA profiles in ID8-T6 cells bearing mice

(Submitter supplied) We newly invented the EV sheet, which is a unique nanofiber paper to capture extracellular vesicles from around 10 uL of bio-fluids. In this study, we investigated miRNA profiles of ID8-T6 cells bearing mice.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL21626 GPL16417
32 Samples

Download data: XLSX

Series

Accession:: GSE216793

ID:: 200216793

PubMed Full text in PMC Similar studies

Select item 2002358619.

The subacromial bursa regulates rotator cuff tendon healing and is a target to augment tendon repair.

(Submitter supplied) Rotator cuff injuries result in over 500,000 surgeries performed annually, an alarmingly high number of which fail. These procedures typically involve repair of the injured tendon and removal of the subacromial bursa. However, recent identification of a resident population of mesenchymal stem cells and inflammatory responsiveness of the bursa to tendinopathy indicate an unexplored biological role of the bursa in the context of rotator cuff disease. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25947
46 Samples

Download data: CSV, TXT

Series

Accession:: GSE235861

ID:: 200235861

PubMed Similar studies

Select item 20022412310.

Changes in miRNA expression during infection with strong IBDV strains

(Submitter supplied) In our previous studies, we found that the bursae of Fabricius in chickens infected with IBDV were severely atrophied and resulted in immune suppression in the chickens. Therefore, we decided to detect the differential expression of miRNA in chickens infected with IBDV by RNA-seq. We then used the data obtained from bursa of Fabricius RNA-seq for gene expression profiling. Our ultimate goal is to study the regulatory mechanisms of host mirnas on IBDV viruses or cells.

Organism:: Gallus gallus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL26853
2 Samples

Download data: TXT

Series

Accession:: GSE224123

ID:: 200224123

Select item 20022071411.

Oral administration of engineered yeast produced H5HA-based vaccines

(Submitter supplied) H5N8 influenza virus is a highly pathogenic pathogen for the poultry and human. Vaccination is the most effective method to control the spread of the virus right now. The traditional inactivated vaccine, though well developed and used widely, is laborious during application and more interests are stimulated in developing alternative approaches. In this study, we developed three HA gene-based yeast vaccines and our experimental results demonstrated that all of these vaccines elicited the humoral immunity, inhibited viral load in the chicken tissues, and provided protective efficacy partially due to the high dose of H5N8 virus. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19005
9 Samples

Download data: CSV, TXT

Series

Accession:: GSE220714

ID:: 200220714

PubMed Full text in PMC Similar studies

Select item 20018554412.

Evolution of hypervirulence during bloodstream adaptation of CA-MRSA strain USA300

(Submitter supplied) The epidemic community-acquired methicillin-resistant S. aureus (CA-MRSA) clone USA300 has recently become a leading cause of hospital-associated bloodstream infections (BSI). Leveraging this recent introduction into hospitals and the limited genetic variation across the USA300 strains, we combined microbial comparative genomics with phenotypic analyses to discover adaptive mutations. USA300 isolates from BSI were found to have independently evolved single nucleotide variants in the transcriptional regulator sarZ. more...

Organism:: Staphylococcus aureus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL27158
42 Samples

Download data: TXT

Series

Accession:: GSE185544

ID:: 200185544

SRA Run Selector

Select item 20018085713.

RNA-Seq analysis of traumatic and degenerative tears of subacromial bursal tissues of human shoulder joint

(Submitter supplied) Objective: To identify transcript level differences between traumatic and degenerative tears of subacromial bursal tissues in shoulder joint using RNA-seq. Methods: Bursal tissues were collected from female and male patients with traumatic or degenerative tears during arthroscopic surgery (N=32). Differentially expressed transcript between traumatic and degenerative tears were detected by RNA-seq and biological processes were identified computationally. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
31 Samples

Download data: TXT

Series

Accession:: GSE180857

ID:: 200180857

Select item 20015189614.

Transcriptional response of turkey blood leukocytes challenged with Salmonella enterica serovar Typhimurium UK1

(Submitter supplied) Salmonella is one of most common causes of bacterial foodborne disease and consumption of contaminated poultry products, including turkey, is one route of exposure. Minimizing colonization of commercial turkeys with Salmonella could reduce the incidence of Salmonella-associated human foodborne illness. Understanding host responses to these bacteria could lead to potential strategies to minimize colonization and thus food safety risk. more...

Organism:: Meleagris gallopavo

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28636
7 Samples

Download data: TXT

Series

Accession:: GSE151896

ID:: 200151896

SRA Run Selector

Select item 20016737715.

From nasal to basal: Single-cell sequence illustrates the winding infection route for IBDV and its influence on bursal cells

(Submitter supplied) Nasal cavity is the main gateway for pathogen infection although it composed of many layers of defending barriers. Pathogens strongly willing to enter and infect from nasal cavity with the dominant form aerosol or respiratory droplets. However, the underlying mechanism of virus nasal infection and transmission are still unknown. Hence, a better understanding of this mechanism may provide insight into the pathogenesis of virus. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE167377

ID:: 200167377

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018379116.

Transcriptome analysis reveals the roles of long non-coding RNA and mRNA in bursa of Fabricius during pigeon (Columba livia) development

(Submitter supplied) We identified 13,072 mRNAs and 19,129 lncRNAs, of which 2,977 mRNAs and 1,527 lncRNAs were differential expressed in pigeon BFs over three developmental stages.

Organism:: Columba livia

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL29485
9 Samples

Download data: TXT

Series

Accession:: GSE183791

ID:: 200183791

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015240717.

Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse oocytes during follicular formation

(Submitter supplied) To delineate the developmental trajectory of oocyte during the process, we performed RNA-seq on single germ cells from newborn (P0.5) ovaries and identified a series of genes that may function between stage transitions. The significant decrease of meiosis-related genes and the dramatic increase of oocyte-specific genes marked the transition of germ cell to a functional oocyte. Our data highlighted the complexity of transcriptional control and depicted the regulatons and their regulatory networks in oocyte development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
146 Samples

Download data: TXT

Series

Accession:: GSE152407

ID:: 200152407

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016602618.

The severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses following ex vivo stimulation of primary bursal cells.

(Submitter supplied) Transcriptomics analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses following ex vivo stimulation of primary bursal cells. In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated very virulent (vv) IBDV into White Leghorn chickens from inbred line W that previously had over 24% mortality, and three inbred lines (15I, C.B4 and O) that previously had 0% mortality. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16133
26 Samples

Download data: TXT

Series

Accession:: GSE166026

ID:: 200166026

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016625719.

Chicken (Gallus gallus) Transcriptome of Intestinal, Immune, and Reproductive Cell and Tissue Types

(Submitter supplied) We report the transcriptomes of 10 different chicken (Gallus gallus) cell/tissue types. The goal of this project was to determine similarities and differences between different cell/tissue types, with respect to protein coding genes, lncRNA, isoform counts, and differential gene expression. We provide raw data and bigWig files for UCSC visualization. The findings described here will be useful towards a complete annotation of chicken tissue and cellular transcriptomes.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24517
20 Samples

Download data: BW

Series

Accession:: GSE166257

ID:: 200166257

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016425220.

DNA molecular combing-based replication fork directionality profiling

(Submitter supplied) The replication strategy of metazoan genomes is still unclear, mainly because definitive maps of replication origins are missing. High-throughput methods are based on population average and thus may exclusively identify efficient initiation sites, whereas ineffective origins go undetected. Single-molecule analyses of specific loci can detect both common and rare initiation events along the targeted regions. more...

Organism:: Gallus gallus

Type:: Other

Platform:: GPL16506
6 Samples

Download data: BW

Series

Accession:: GSE164252

ID:: 200164252

PubMed Full text in PMC Similar studies SRA Run Selector

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