basler deflexa - GEO DataSets

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Select item 2002668791.

Activation of the innate immune system accelerates growth in cooperation with oncogenic Ras.

(Submitter supplied) Innate immunity in Drosophila acts as an organismal surveillance system that measures external stimuli or cellular fitness and triggers context-specific responses to fight infections and maintain tissue homeostasis. However, uncontrolled activation of innate immune pathways can be detrimental to the system. In mammals, innate immune signaling is often overactivated in malignant cells and contributes to tumor progression. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
12 Samples

Download data: TSV

Series

Accession:: GSE266879

ID:: 200266879

Select item 2002661602.

RoCK and ROI: a single-cell RNA-sequencing method with enhanced transcriptome information via targeted enrichment of transcripts and preselected, region-specific sequencing III

(Submitter supplied) Many scRNAseq-based methods suffer from a high number of non-detects and a bias towards the 3' or 5' end of transcripts. We developed a method termed RoCK and ROI to address these two biases. RoCK and ROI leads to the enrichment of the transcriptome profile of cells with information on transcripts of interest

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: BW, CSV, GTF, MTX, TSV

Series

Accession:: GSE266160

ID:: 200266160

Select item 2002661173.

RoCK and ROI: a single-cell RNA-sequencing method with enhanced transcriptome information via targeted enrichment of transcripts and preselected, region-specific sequencing II

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL25526 GPL24676
4 Samples

Download data: BW, CSV, GTF, MTX, TSV

Series

Accession:: GSE266117

ID:: 200266117

Select item 2002659624.

RoCK and ROI: a single-cell RNA-sequencing method with enhanced transcriptome information via targeted enrichment of transcripts and preselected, region-specific sequencing I

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25526
2 Samples

Download data: BW, CSV, GTF, MTX, TSV

Series

Accession:: GSE265962

ID:: 200265962

Select item 2002253795.

Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage and replication stress in murine gastric stem and progenitor cells [scRNA-seq]

(Submitter supplied) Helicobacter pylori infection is a major risk factor for the development of gastric cancer. The bacteria reside in close proximity to gastric surface mucous as well as stem and progenitor cells. Here, we take advantage of wild type and genetically engineered murine gastric organoids and organoid-derived monolayers to study the cellular targets of H. pylori-induced DNA damage and replication stress, and to explore possible interactions with preexisting gastric cancer driver mutations. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE225379

ID:: 200225379

PubMed Full text in PMC Similar studies

Select item 2002251896.

Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage and replication stress in murine gastric stem and progenitor cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
24 Samples

Download data: TXT

Series

Accession:: GSE225189

ID:: 200225189

PubMed Full text in PMC Similar studies

Select item 2002166997.

Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfb superfamily

(Submitter supplied) The protective and absorptive functions of the intestinal epithelium rely on differentiated enterocytes in the villi. The differentiation of enterocytes is orchestrated by sub-epithelial mesenchymal cells producing distinct ligands along the villus axis, in particular Bmps and Tgf. Here we show that individual Bmp ligands and Tgf drive distinct enterocytic programs specific to villus zonation. Bmp4 is expressed mainly from the centre to the upper part of the villus, and it activates preferentially genes connected to lipid uptake and metabolism. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
28 Samples

Download data: CSV

Series

Accession:: GSE216699

ID:: 200216699

PubMed Full text in PMC Similar studies

Select item 2001527288.

Infection of bats and cell cultures with Marburg, Ebola and Rabies viruses

(Submitter supplied) The response of bats to filoviral infections was studied to understand how they avoid getting sick

Organism:: Chiroptera

Type:: Expression profiling by high throughput sequencing

Platform:: GPL28706
179 Samples

Download data: CSV, FA

Series

Accession:: GSE152728

ID:: 200152728

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002069399.

Nonclassical beta catenin signaling regulate skeletal cell fate determination

(Submitter supplied) To rigorously examine the role of b-catenin dependent transcription, we created mice deficient for the transcriptional output of beta-catenin in skeletal mesenchyme (bcat-dTF-Dermo1-cKO) and compare the transcriptional profiles to that of the beta-catenin conditional KO mice in skeletal mesenchyme (bcat-Dermo1-cKO).

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16331
3 Samples

Download data: TXT

Series

Accession:: GSE206939

ID:: 200206939

PubMed Full text in PMC Similar studies

Select item 20018200110.

Active eosinophils regulate host defense and immune responses during intestinal inflammation

(Submitter supplied) In the past decade, single-cell transcriptomics has helped uncover new cell types and states and led to the construction of a cellular compendium of health and disease1. Still, some difficult-to-sequence cell types remain absent from cell atlases. Eosinophils, elusive granulocytes implicated in a plethora of human pathologies2,3, are among these uncharted cell types. To date, the heterogeneity of eosinophils and the gene programs underpinning their pleiotropic functions remain poorly understood4. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: TXT, XLS

Series

Accession:: GSE182001

ID:: 200182001

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018173811.

Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma

(Submitter supplied) Colon cancer is initiated by stem cells that escape the strict control. In most colon tumors this process is driven through aberrant activation of Wnt signaling by mutations that occur in components acting downstream of the receptor complex and that unfetter tumor cells from the need for Wnt ligands. Here we describe a special type of colon cancer that does not depend on mutated core components of the Wnt pathway. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: CSV

Series

Accession:: GSE181738

ID:: 200181738

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018159512.

Human kidney organoid scRNA-seq (from study: Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis)

(Submitter supplied) Human iPSC-derived kidney organoids used for genome-wide CRISPR screening were profiled using scRNA-seq to characterize the maturation state at day 21, 28 and 35. Unsupervised clustering attributed cell types to segmented epithelium, podocytes and stroma and revealed stable cell type identity over time with a fibrotic signature in the stroma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
7 Samples

Download data: H5

Series

Accession:: GSE181595

ID:: 200181595

Select item 20015400713.

Tracing colonic embryonic transcriptional programs and their reactivation in inflammatory disease at single cell level

(Submitter supplied) Purpose: determine transcriptional programs active during hindgut development and their reactivation in inflammatory disease; Summary: Our analyses reveal that most adult cell lineages are established by the late embryonic stage. In addition we find reactivation of embryonic features in inflammatory disease.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: TXT

Series

Accession:: GSE154007

ID:: 200154007

PubMed Similar studies SRA Run Selector

Select item 20011078214.

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling (RNA-seq data set)

(Submitter supplied) Gene expression profiling of Pygo2 mutant branchyal arches (BA) and developing heart tubes at 10.5 days post coitum

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: XLSX

Series

Accession:: GSE110782

ID:: 200110782

SRA Run Selector

Select item 20011078115.

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling (ChIP-seq data set)

(Submitter supplied) Genome-wide DNA binding profiles of the components of the Wnt signaling transcriptional complex, beta-catenin and Pygo2, in mouse developing branchyal arches (BA) and looping heart.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
7 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE110781

ID:: 200110781

SRA Run Selector

Select item 20015125716.

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis

(Submitter supplied) Purpose: to determine cellular heterogeneity of the murine colonic epithelium and mesenchyme; Summary: We determined 16 disctinct sub-populations of colonic epithelial and mesenchymal cells. Further we found 3 distinct sub-populations of colonic PdgfraEGFP-positive fibroblasts.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: TXT

Series

Accession:: GSE151257

ID:: 200151257

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013306817.

Pygopus2-Histone interaction is important for de-differentiation and breast cancer progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
32 Samples

Download data: BEDGRAPH

Series

Accession:: GSE133068

ID:: 200133068

PubMed Similar studies

Select item 20013306618.

Pygopus2-Histone interaction is important for de-differentiation and breast cancer progression [ATAC-Seq]

(Submitter supplied) Pygopus2 (Pygo2), a co-activator of Wnt/ β-catenin signaling can also bind H3K4me2/3 and participate in chromatin reading and writing. To investigate the functional relevance of histone binding activity of Pygo2 in malignant progression of breast cancer, we generated a knockin mouse model wherein binding of Pygo2 to H3K4me2/3 was rendered ineffective. Loss of Pygo2-histone binding resulted in smaller, differentiated and less metastatic tumors, at least in part due to a decrease in Wnt/ b-catenin signaling. more...