4-Chloro-4'-iodobenzophenone - GEO DataSets

Select item 2002111831.

In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals

(Submitter supplied) Since initial regulatory action in 2010 in Canada, bisphenol A (BPA) has been progressively replaced by structurally related alternative chemicals. Unfortunately, many of these chemicals are data-poor, limiting toxicological risk assessment. We used high-throughput transcriptomics to evaluate potential hazards and compare potencies of BPA and 15 BPA alternative chemicals in cultured breast cancer cells. more...

Organism:: synthetic construct; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19424
768 Samples

Download data: CSV

Series

Accession:: GSE211183

ID:: 200211183

PubMed Full text in PMC Similar studies

Select item 2001245642.

Development of a Classification Taxonomy for Adipogenic Chemicals: A Novel Tool for Identifying Emerging Metabolic Health Threats

(Submitter supplied) Growing evidence suggests that chemicals in disparate structural classes activate specific subsets of PPARγ’s transcriptional programs to generate adipocytes with distinct phenotypes. Our objectives were to 1) establish a novel classification method to predict PPARγ-interacting and modifying chemicals and 2) create taxonomy labels to group chemicals based on their effects on PPARγ’s transcriptome and downstream metabolic functions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
249 Samples

Download data: TXT

Series

Accession:: GSE124564

ID:: 200124564

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000599273.

Drug Matrix Data - CodeLink Arrays

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platforms:: GPL5426 GPL5425 GPL5424
12921 Samples

Download data: TXT

Series

Accession:: GSE59927

ID:: 200059927

Analyze with GEO2R

Select item 2000599134.

Exposure of rat to a variety of toxicants, kidney assayed by CodeLink microarray

(Submitter supplied) DrugMatrix is a comprehensive rat toxicogenomics database and analysis tool developed to facilitate the integration of toxicogenomics into hazard assessment. Using the whole genome and a diverse set of compounds allows a comprehensive view of most pharmacological and toxicological questions and is applicable to other situations such as disease and development.