GEO DataSets

(Submitter supplied) Feline hyperthyroidism (FHT) is a debilitating disease affecting >10% of elderly cats. It is generally characterised by chronic elevation of thyroid hormone in the absence of circulating TSH. Understanding of the molecular pathogenesis of FHT is currently limited. However, FHT shares clinical and histopathological similarities with human toxic multinodular goitre, which has been associated with activating mutations in TSH receptor (TSHR) and Gsα encoding genes. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28702

15 Samples

Download data: TXT

(Submitter supplied) Sperm maturation depends on exposure to specific microenvironments within the different segments of the epididymis, but mechanisms underlying how these microenvironments are produced or maintained are not well understood. We hypothesize that epididymal extracellular vesicles (EVs) could play a role in this process, and therefore set out to test whether the EVs from different regions of the epididymis can serve as a form of paracrine communication between epithelial cells. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28702

15 Samples

Download data: TXT

(Submitter supplied) Introduction: The domestic cat (Felis catus) is a valued companion animal and the second most popular pet (over 46.5 million US households). They are also an important model system for virally-induced cancers (feline leukemia virus) and virally-mediated immunodeficiency (feline immunodeficiency virus). However, species specific research limitations such as a lack of reagents and immune cell markers limit our ability to utilize these models to their full capacity. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28702

8 Samples

Download data: CSV, TAR

(Submitter supplied) Single RNA sequencing analysis of myosin binding protein C3 (mybpc-3) associated Hypertrophic Cardiomyopathy to identify single cell gene expression changes across common pathological mechanisms and species-specific distinctions in human, feline, and murine heart tissues.

Organism:

Mus musculus; Felis catus; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL24676 GPL28702

29 Samples

Download data: MTX, TSV

(Submitter supplied) Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation and ulceration of the caudal oral mucosa, alveolar and buccal mucosa, and varying degrees of periodontal disease. The etiopathogenesis of FCGS remains unresolved. In this study, we performed bulk RNA-seq molecular profiling of affected tissues derived from a cohort of client-owned cats with FCGS compared to tissues from unaffected animals, to identify candidate genes and pathways that can help guide future exploration of novel clinical solutions. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28702

29 Samples

Download data: TXT

(Submitter supplied) Three-dimensional genome architecture influences the regulation of essential nuclear processes, such as gene transcription. However, how 3D genome architecture is affected by evolutionary forces within major lineages remains unclear. Here, we report a comprehensive comparison of 3D genomes, using high resolution Hi-C data in fibroblast cells of fish, chickens, and 10 mammalian species. This analysis shows a correlation between genome size and chromosome length that affects chromosomal territory (CT) organization in the upper hierarchy of genome architecture, whereas lower hierarchical features, including local transcriptional availability of DNA, are selected through vertebrate’s evolution. more...

Organism:

Gallus gallus; Sus scrofa; Oryctolagus cuniculus; Mus musculus; Danio rerio; Macaca mulatta; Homo sapiens; Canis lupus familiaris; Felis catus; Bos taurus; Ovis aries; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

12 related Platforms

29 Samples

Download data: TXT

(Submitter supplied) Three-dimensional genome architecture influences the regulation of essential nuclear processes, such as gene transcription. However, how 3D genome architecture is affected by evolutionary forces within major lineages remains unclear. Here, we report a comprehensive comparison of 3D genomes, using high resolution Hi-C data in fibroblast cells of fish, chickens, and 10 mammalian species. This analysis shows a correlation between genome size and chromosome length that affects chromosomal territory (CT) organization in the upper hierarchy of genome architecture, whereas lower hierarchical features, including local transcriptional availability of DNA, are selected through vertebrate’s evolution. more...

Organism:

Canis lupus familiaris; Homo sapiens; Mus musculus; Felis catus; Bos taurus; Ovis aries; Oryctolagus cuniculus; Rattus norvegicus; Danio rerio; Gallus gallus; Macaca mulatta

Type:

Other

11 related Platforms

25 Samples

Download data: BED, HDF5, XLS

(Submitter supplied) The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening on animal cells is a powerful tool to reveal the expression patterns of viral entry genes for different hosts. But such exploration for SARS-CoV-2 remained limited. Here, we presented the broadest pan-species single-nucleus RNA sequencing study to date, covering 11 representative species in pets (cat, dog, hamster, lizard), livestock (goat, rabbit), poultry (duck, pigeon) and wildlife (pangolin, tiger, deer), from which we investigated the co-expression of ACE2 and TMPRSS2. more...

Organism:

Oryctolagus cuniculus; Mesocricetus auratus; Columba livia; Felis catus; Capra aegagrus; Manis javanica; Cervus nippon taiouanus; Anas platyrhynchos; Canis lupus familiaris; Anolis carolinensis; Panthera tigris altaica

Type:

Expression profiling by high throughput sequencing

11 related Platforms

29 Samples

Download data: TXT

(Submitter supplied) In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1 month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24552

36 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris; Cavia porcellus; Sus scrofa; Mus musculus; Gallus gallus; Macaca mulatta; Homo sapiens; Felis catus; Ovis aries; Oryctolagus cuniculus; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

19 related Platforms

553 Samples

Download data: HIC, TXT

(Submitter supplied) Comprehensive transcriptomic survey of the pig (Sus scrofa) may lead to a better understanding of mechanisms of tissue specialization that underlie economic traits of this species and accelerate its use as a biomedical model. Here, we characterized four distinct transcript types (lncRNAs, TUCPs, miRNAs and circRNAs) in 31 adult pig tissues and two cell lines, together with protein-coding genes. We dissected their distinct structural and transcriptional features and uncovered transcriptome variability as related to tissue physiology. more...

Organism:

Gallus gallus; Ovis aries; Oryctolagus cuniculus; Macaca mulatta; Felis catus; Mus musculus; Rattus norvegicus; Canis lupus familiaris; Cavia porcellus

Type:

Expression profiling by high throughput sequencing

9 related Platforms

142 Samples

Download data: TXT

(Submitter supplied) Comprehensive transcriptomic survey of the pig (Sus scrofa) may lead to a better understanding of mechanisms of tissue specialization that underlie economic traits of this species and accelerate its use as a biomedical model. Here, we characterized four distinct transcript types (lncRNAs, TUCPs, miRNAs and circRNAs) in 31 adult pig tissues and two cell lines, together with protein-coding genes. We dissected their distinct structural and transcriptional features and uncovered transcriptome variability as related to tissue physiology. more...

Organism:

Sus scrofa; Oryctolagus cuniculus; Felis catus; Ovis aries; Rattus norvegicus; Canis lupus familiaris

Type:

Genome binding/occupancy profiling by high throughput sequencing

6 related Platforms

16 Samples

Download data: HIC, TXT

(Submitter supplied) We apply developmental and single cell gene expression analysis to fetal skin of domestic cats, together with genetic characterization of Mendelian color variation, to identify when, where, and how, during fetal development, felid color patterns are established. Prior to the appearance of hair follicle placodes, we identify changes in epidermal thickness that represent a signature of color pattern establishment, and that are preceded by a pre-pattern of gene expression in which the secreted Wnt inhibitor encoded by Dickkopf 4 (Dkk4) plays a central role. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17081

3 Samples

Download data: H5

(Submitter supplied) Purporse: FPV can cause a viral disease that occurs in cats, causing severe leukopenia, gastro-enteritis and nervous signs and leads to significant losses. LncRNAs biochemically resemble mRNAs posited by Jacob and Monod, yet do not template protein synthesis. Rather, lncRNAs functioning as RNA genes to play an important role in many biological and pathological processes such as inflammation and viral infection. more...

Organism:

Felis catus

Type:

Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL23056

6 Samples

Download data: FA, XLSX

(Submitter supplied) Purpose:MicroRNAs (miRNAs) are members of a rapidly growing class of small endogenous non-coding RNAs that play crucial roles in post-transcriptional regulator of gene expression in many biological processes. Feline Panleukopenia Virus (FPV) is a highly infectious pathogen that causes severe disease in pets, economically important animals and wildlife in worldwide. However, the molecular mechanisms underlying the pathogenicity of FPV have not been completely clear. more...

Organism:

Felis catus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL24552

6 Samples

Download data: XLS

(Submitter supplied) The purpose of this study was to characterize the transcriptomic alterations accompanying the inflammation involved in feline chronic gingivostomatitis (FCGS). Towards this goal next-generation sequencing (NGS)-based gene expression profiling (RNA-Sequencing; RNA-Seq) was performed on matched pairs of FCGS diseased and healthy tissues obtained from three feline subjects.

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26066

6 Samples

Download data: TXT

(Submitter supplied) Glaucoma, a multifactorial neurodegenerative disease characterized by progressive loss of retinal ganglion cells and their axons in the optic nerve, is a leading cause of irreversible vision loss. Intraocular pressure (IOP) is a risk factor for axonal damage, which initially occurs at the optic nerve head (ONH). Complex cellular and molecular mechanisms involved in the pathogenesis of glaucomatous optic neuropathy remain unclear. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17081

16 Samples

Download data: GTF, TXT

(Submitter supplied) We utilized high-throughput small RNA-seq technology to investigate the altered miRNA profiling in miRNA libraries from uninfected (Control) and canine parvovirus type 2c (CPV-2c) infected Crandell Reese Feline Kidney (CRFK) cells. We identified five of known miRNAs (miR-222-5p, miR-365-2-5p, miR-1247-3p, miR-322-5p, and miR-361-3p) and 3 novel miRNAs (Novel 137, Novel 141, and Novel 102) by small RNA-seq with differentially expressed genes (DEGs) in the miRNA repertoire of CPV-infected cells over control. more...

Organism:

Felis catus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL17081

4 Samples

Download data: CSV

(Submitter supplied) We use the Next generation sequencing (RNAseq) to profiling gene expression of CRFK cell.The purpose of this study are to comparison of CRFK gene expression between uninfected and infected by CPV isolated from Laos PDR

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17081

4 Samples

Download data: CSV

(Submitter supplied) Purpose: To study the effects of raltegravir treatment for corneal cells on host gene expression during FHV-1 infection and in uninfected cells. Method: For examination of effects in infected cells, corneal cells were infected with FHV-1 for 2 hours and treated with raltegravir or DMSO for 2 h. For examination of effects in uninfected cells, corneal cells were infected with FHV-1 for 2 h. Data was analyzed using a standard pipeline. more...

Organism:

Felis catus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24552

12 Samples

Download data: DIFF, GTF, TXT