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Links from MedGen

Items: 87

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
NALCN
Single nucleotide variant
(splice donor variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(F317L)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(R143W)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GUncertain significance
NALCN
(G236V)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(R744C)
Single nucleotide variant
(missense variant +1 more)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(D1206fs +2 more)
Deletion
(frameshift variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(K1173Q +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(T792A +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(I51N)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN, NALCN-AS1
(R1693G +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(R173Q)
Single nucleotide variant
(missense variant)
not provided
+1 more
GLikely pathogenic
NALCN
(K1086N +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(A310T)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely benign
NALCN
(I1017S +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(V1414I +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
NALCN
(V568I)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(R152*)
Single nucleotide variant
(nonsense)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GPathogenic
NALCN
(K1051E +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(A1156T +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GPathogenic/Likely pathogenic
NALCN
Single nucleotide variant
(synonymous variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+1 more
GUncertain significance
NALCN
(N1167T +2 more)
Single nucleotide variant
(missense variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+2 more
GUncertain significance
NALCN
(N1041S +2 more)
Single nucleotide variant
(missense variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+1 more
GUncertain significance
NALCN, NALCN-AS1
(G1684D +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Inborn genetic diseases
+3 more
GUncertain significance
NALCN
(R1471W +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(R603* +1 more)
Single nucleotide variant
(nonsense)
See cases
+3 more
GPathogenic/Likely pathogenic
NALCN
(M1215R +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(Q524R +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(I167N)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(Q584R +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
Single nucleotide variant
(intron variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+2 more
GBenign
NALCN
(E1226G +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(S1253L +2 more)
Single nucleotide variant
(missense variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+2 more
GConflicting classifications of pathogenicity
NALCN
(R1059C +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GUncertain significance
NALCN
(H740Q +2 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GConflicting classifications of pathogenicity
NALCN
Duplication
(intron variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+3 more
GBenign/Likely benign
NALCN, NALCN-AS1
(R1625Q +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GUncertain significance
NALCN
(A1062E +2 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GUncertain significance
NALCN
(T73S)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
Single nucleotide variant
(intron variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(M958T +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(M86K)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(R1145S +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GPathogenic/Likely pathogenic
NALCN
Single nucleotide variant
(splice donor variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(G1087C +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GBenign
NALCN
(R295fs)
Deletion
(frameshift variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(L934V +2 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
NALCN
(L1179I +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic
NALCN
Microsatellite
(intron variant)
not provided
+1 more
GBenign
NALCN
Single nucleotide variant
(synonymous variant)
not provided
+2 more
GBenign/Likely benign
NALCN
Single nucleotide variant
(synonymous variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+2 more
GBenign/Likely benign
LOC126861831, NALCN
Single nucleotide variant
(intron variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+2 more
GBenign/Likely benign
NALCN
(D571G +1 more)
Single nucleotide variant
(missense variant)
NALCN-related disorder
+1 more
GPathogenic/Likely pathogenic
NALCN
(R1384* +2 more)
Single nucleotide variant
(nonsense)
NALCN-related disorder
+1 more
GPathogenic
NALCN
(E784fs +2 more)
Duplication
(frameshift variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+1 more
GPathogenic
NALCN, NALCN-AS1
(D1737H +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(S524N +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(D600E +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN-AS1, NALCN
(E1730K +2 more)
Single nucleotide variant
(non-coding transcript variant +1 more)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GUncertain significance
NALCN
Single nucleotide variant
(splice donor variant)
Hypotonia, infantile, with psychomotor retardation and characteristic facies 1
+3 more
GPathogenic/Likely pathogenic
NALCN
(I1022V +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GConflicting classifications of pathogenicity
NALCN
(V559L +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GUncertain significance
NALCN
(I322T)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
NALCN
(M547V +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
(R329G)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GLikely pathogenic
NALCN
Single nucleotide variant
(synonymous variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+3 more
GBenign
NALCN
Single nucleotide variant
(synonymous variant)
not specified
+3 more
GBenign
NALCN
Single nucleotide variant
(intron variant)
not provided
+2 more
GBenign
NALCN
Single nucleotide variant
(synonymous variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+2 more
GBenign/Likely benign
NALCN
Single nucleotide variant
(intron variant)
not provided
+3 more
GBenign/Likely benign
NALCN
Single nucleotide variant
(intron variant)
not specified
+3 more
GBenign
NALCN
Single nucleotide variant
(synonymous variant)
not specified
+3 more
GBenign
NALCN
(Y578C +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
+1 more
GPathogenic/Likely pathogenic
NALCN
(L312I)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(E327K)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(F512V +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(T513N +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(V1006A +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(I1017T +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(T1165P +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(I1446M +2 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(R735* +2 more)
Single nucleotide variant
(nonsense)
not provided
+2 more
GPathogenic
NALCN
(R1181Q +2 more)
Single nucleotide variant
(missense variant)
not provided
+2 more
GPathogenic/Likely pathogenic
NALCN
(Y578S +1 more)
Single nucleotide variant
(missense variant)
not provided
GPathogenic
NALCN
(L509S +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(L590F +1 more)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(V313G)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
NALCN
(Q177P)
Single nucleotide variant
(missense variant)
Congenital contractures of the limbs and face, hypotonia, and developmental delay
GPathogenic
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