ClinVar for Gene (Select 79728) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3344550	NM_024675.4(PALB2):c.2053A>T (p.Lys685Ter)	PALB2 (K390* +3 more)	Single nucleotide variant (nonsense +1 more)	PALB2-related disorder	GLikely pathogenic
Select item 3344066	NM_024675.4(PALB2):c.3114G>T (p.Trp1038Cys)	PALB2 (R945S +8 more)	Single nucleotide variant (missense variant +1 more)	PALB2-related disorder	GUncertain significance
Select item 3340220	NM_024675.4(PALB2):c.3550C>A (p.His1184Asn)	PALB2 (H1091N +10 more)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 3340218	NM_024675.4(PALB2):c.1261A>G (p.Arg421Gly)	PALB2 (R126G +2 more)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 3337765	NM_024675.4(PALB2):c.3114-795_3201+1238del	PALB2	Deletion (intron variant +2 more)	not provided	GLikely pathogenic
Select item 3337764	NM_024675.4(PALB2):c.2586+860_2749-723del	PALB2	Deletion (splice acceptor variant +2 more)	not provided	GLikely pathogenic
Select item 3337436	NM_024675.4(PALB2):c.443del (p.Lys148fs)	PALB2 (K128fs +1 more)	Deletion (frameshift variant +2 more)	not provided	GPathogenic
Select item 3337435	NM_024675.4(PALB2):c.2748+1del	PALB2	Deletion (splice donor variant +1 more)	not provided	GLikely pathogenic
Select item 3337433	NM_024675.4(PALB2):c.3350+1G>C	PALB2	Single nucleotide variant (intron variant +1 more)	not provided	GLikely pathogenic
Select item 3304013	NM_024675.4(PALB2):c.1976T>C (p.Leu659Pro)	PALB2 (L639P +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304012	NM_024675.4(PALB2):c.1635A>G (p.Glu545=)	PALB2	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3304011	NM_024675.4(PALB2):c.1660G>T (p.Glu554Ter)	PALB2 (E554* +2 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3304010	NM_024675.4(PALB2):c.3320_3329delinsCCTG (p.Leu1107_Leu1110delinsProCys)	PALB2	Indel (inframe_indel +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304009	NM_024675.4(PALB2):c.1073C>G (p.Pro358Arg)	PALB2 (P63R +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304008	NM_024675.4(PALB2):c.261T>A (p.His87Gln)	PALB2 (H87Q +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304007	NM_024675.4(PALB2):c.1453A>C (p.Thr485Pro)	PALB2 (T190P +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304006	NM_024675.4(PALB2):c.3101A>T (p.Asn1034Ile)	PALB2 (N1014I +7 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3304005	NM_024675.4(PALB2):c.2832C>T (p.Ile944=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3304004	NM_024675.4(PALB2):c.2381_2387delinsC (p.Arg794_Gly796delinsThr)	PALB2	Indel (inframe_indel +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304003	NM_024675.4(PALB2):c.797C>G (p.Pro266Arg)	PALB2 (P266R +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304002	NM_024675.4(PALB2):c.3241G>C (p.Glu1081Gln)	PALB2 (E1061Q +8 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304001	NM_024675.4(PALB2):c.494G>C (p.Gly165Ala)	PALB2 (G145A +1 more)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3304000	NM_024675.4(PALB2):c.1596A>G (p.Pro532=)	PALB2	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303999	NM_024675.4(PALB2):c.3088A>C (p.Thr1030Pro)	PALB2 (T1006P +7 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303998	NM_024675.4(PALB2):c.-2C>A	PALB2	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303997	NM_024675.4(PALB2):c.291T>C (p.Ser97=)	PALB2	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303996	NM_024675.4(PALB2):c.1794G>C (p.Leu598=)	PALB2	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303995	NM_024675.4(PALB2):c.2252C>G (p.Ala751Gly)	PALB2 (A731G +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303994	NM_024675.4(PALB2):c.3171T>G (p.Ala1057=)	PALB2	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303993	NM_024675.4(PALB2):c.1373C>G (p.Thr458Ser)	PALB2 (T163S +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303992	NM_024675.4(PALB2):c.1484A>T (p.Glu495Val)	PALB2 (E495V +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303991	NM_024675.4(PALB2):c.1483_1484delinsTT (p.Glu495Leu)	PALB2 (E495L +2 more)	Indel (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303990	NM_024675.4(PALB2):c.2782G>T (p.Val928Leu)	PALB2 (V106L +7 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303989	NM_024675.4(PALB2):c.597T>C (p.Leu199=)	PALB2	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303988	NM_024675.4(PALB2):c.2829_2830del (p.Glu943fs)	PALB2 (E923fs +7 more)	Microsatellite (frameshift variant)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3303987	NM_024675.4(PALB2):c.2793C>A (p.Leu931=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303986	NM_024675.4(PALB2):c.3026dup (p.Pro1009_Glu1010insTer)	PALB2	Duplication (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3303985	NM_024675.4(PALB2):c.922G>T (p.Ala308Ser)	PALB2 (A13S +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303984	NM_024675.4(PALB2):c.1826T>C (p.Ile609Thr)	PALB2 (I314T +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3303983	NM_024675.4(PALB2):c.3406A>G (p.Thr1136Ala)	PALB2 (T1082A +10 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3303982	NM_024675.4(PALB2):c.2353C>A (p.Pro785Thr)	PALB2 (P189T +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3256300	NM_024675.4(PALB2):c.212-25T>G	PALB2	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3254411	NM_024675.4(PALB2):c.3255_3256delinsTT (p.Leu1085_Arg1086delinsPheTer)	PALB2	Indel (nonsense +1 more)	Familial cancer of breast	GPathogenic
Select item 3254388	NM_024675.4(PALB2):c.3467_3468del (p.Asp1156fs)	PALB2 (D1063fs +10 more)	Deletion (frameshift variant +1 more)	Familial cancer of breast	GLikely pathogenic
Select item 3254376	NM_024675.4(PALB2):c.1145_1146insGTTG (p.Ser382fs)	PALB2 (S362fs +2 more)	Insertion (frameshift variant +1 more)	Familial cancer of breast	GPathogenic
Select item 3254337	NM_024675.4(PALB2):c.1516del (p.Gln506fs)	PALB2 (Q211fs +2 more)	Deletion (frameshift variant +1 more)	Familial cancer of breast	GPathogenic
Select item 3254153	NM_024675.4(PALB2):c.2997-1G>C	PALB2	Single nucleotide variant (splice acceptor variant +1 more)	Familial cancer of breast	GLikely pathogenic
Select item 3243357	NC_000016.9:g.(?_23605874)_(23640542_?)del	NDUFAB1, PALB2	Deletion	Familial cancer of breast	GPathogenic
Select item 3243356	NC_000016.9:g.(?_23638673)_(23641020_?)del	PALB2	Deletion	Familial cancer of breast	GLikely pathogenic
Select item 3243355	NC_000016.9:g.(?_23640324)_(23646511_?)del	PALB2	Deletion	Familial cancer of breast	GLikely pathogenic
Select item 3243354	NC_000016.9:g.(?_23647371)_(23700359_?)del	DCTN5, PALB2 +1 more	Deletion	Familial cancer of breast	GPathogenic
Select item 3243353	NC_000016.9:g.(?_23637537)_(23641810_?)dup	PALB2	Duplication	Familial cancer of breast	GLikely pathogenic
Select item 3243352	NC_000016.9:g.(?_23637547)_(23652478_?)dup	PALB2	Duplication	Familial cancer of breast	GUncertain significance
Select item 3243351	NC_000016.9:g.(?_23614634)_(23634461_?)del	PALB2	Deletion	Familial cancer of breast	GPathogenic
Select item 3243350	NC_000016.9:g.(?_23632663)_(23634471_?)del	PALB2	Deletion	Familial cancer of breast	GLikely pathogenic
Select item 3243348	NC_000016.9:g.(?_23646173)_(23652478_?)del	PALB2	Deletion	Familial cancer of breast	GPathogenic
Select item 3243347	NC_000016.9:g.(?_23632663)_(23652478_?)del	PALB2	Deletion	Familial cancer of breast	GPathogenic
Select item 3243346	NC_000016.9:g.(?_23614780)_(23652478_?)del	PALB2	Deletion	Familial cancer of breast	GPathogenic
Select item 3240019	NM_024675.4(PALB2):c.3154G>C (p.Asp1052His)	PALB2 (D1028H +8 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3240018	NM_024675.4(PALB2):c.3248A>T (p.Glu1083Val)	PALB2 (E1029V +8 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3240017	NM_024675.4(PALB2):c.3482T>C (p.Phe1161Ser)	PALB2 (F1068S +10 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3240014	NM_024675.4(PALB2):c.573_595dup (p.Leu199delinsGlnTer)	PALB2	Duplication (nonsense +2 more)	Familial cancer of breast	GLikely pathogenic
Select item 3240013	NM_024675.4(PALB2):c.515C>G (p.Ser172Cys)	PALB2 (S152C +1 more)	Single nucleotide variant (missense variant +2 more)	Familial cancer of breast	GUncertain significance
Select item 3240012	NM_024675.4(PALB2):c.1738T>C (p.Tyr580His)	PALB2 (Y285H +2 more)	Single nucleotide variant (missense variant +2 more)	Familial cancer of breast	GUncertain significance
Select item 3240011	NM_024675.4(PALB2):c.1831G>T (p.Asp611Tyr)	PALB2 (D15Y +3 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3240009	NM_024675.4(PALB2):c.1924dup (p.Met642fs)	PALB2 (M347fs +3 more)	Duplication (frameshift variant +1 more)	Familial cancer of breast	GLikely pathogenic
Select item 3240008	NM_024675.4(PALB2):c.1301A>G (p.Asp434Gly)	PALB2 (D139G +2 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3240006	NM_024675.4(PALB2):c.1975C>A (p.Leu659Met)	PALB2 (L364M +3 more)	Single nucleotide variant (missense variant +1 more)	Familial cancer of breast	GUncertain significance
Select item 3234652	NM_024675.4(PALB2):c.660T>G (p.Ser220Arg)	PALB2 (S200R +1 more)	Single nucleotide variant (missense variant +2 more)	not provided	GUncertain significance
Select item 3228052	NM_024675.4(PALB2):c.989A>G (p.Asn330Ser)	PALB2 (N310S +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228051	NM_024675.4(PALB2):c.970A>G (p.Asn324Asp)	PALB2 (N29D +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228050	NM_024675.4(PALB2):c.96A>T (p.Leu32=)	PALB2	Single nucleotide variant (synonymous variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228049	NM_024675.4(PALB2):c.937G>A (p.Gly313Ser)	PALB2 (G18S +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228048	NM_024675.4(PALB2):c.934A>G (p.Ser312Gly)	PALB2 (S17G +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228047	NM_024675.4(PALB2):c.923C>G (p.Ala308Gly)	PALB2 (A13G +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228046	NM_024675.4(PALB2):c.901_902delinsAT (p.Asp301Ile)	PALB2 (D281I +2 more)	Indel (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228045	NM_024675.4(PALB2):c.895T>A (p.Ser299Thr)	PALB2 (S279T +2 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228043	NM_024675.4(PALB2):c.767G>A (p.Ser256Asn)	PALB2 (S236N +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228042	NM_024675.4(PALB2):c.-5G>A	PALB2	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228041	NM_024675.4(PALB2):c.590C>G (p.Thr197Ser)	PALB2 (T177S +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228040	NM_024675.4(PALB2):c.57G>T (p.Glu19Asp)	PALB2 (E19D)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228039	NM_024675.4(PALB2):c.55G>A (p.Glu19Lys)	PALB2 (E19K)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228038	NM_024675.4(PALB2):c.545T>G (p.Ile182Ser)	PALB2 (I162S +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228037	NM_024675.4(PALB2):c.48+3G>T	PALB2	Single nucleotide variant (5 prime UTR variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228036	NM_024675.4(PALB2):c.445_449del (p.Lys149fs)	PALB2 (K129fs +1 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3228035	NM_024675.4(PALB2):c.3526A>G (p.Lys1176Glu)	PALB2 (K1083E +10 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228034	NM_024675.4(PALB2):c.3517G>C (p.Ala1173Pro)	PALB2 (A1080P +10 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228033	NM_024675.4(PALB2):c.3493_3495dup (p.Ser1165_Gly1166insSer)	PALB2	Duplication (inframe_insertion +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228030	NM_024675.4(PALB2):c.336_337delinsA (p.Pro113fs)	PALB2 (P113fs +1 more)	Indel (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3228029	NM_024675.4(PALB2):c.3287A>T (p.Asn1096Ile)	PALB2 (N1003I +8 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228028	NM_024675.4(PALB2):c.3230C>T (p.Pro1077Leu)	PALB2 (P1023L +8 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228027	NM_024675.4(PALB2):c.3221T>C (p.Leu1074Pro)	PALB2 (L1020P +8 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228026	NM_024675.4(PALB2):c.3202G>A (p.Gly1068Arg)	PALB2 (G1014R +8 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228025	NM_024675.4(PALB2):c.3202-3T>G	PALB2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228024	NM_024675.4(PALB2):c.3002A>T (p.Lys1001Ile)	PALB2 (K1001I +7 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228023	NM_024675.4(PALB2):c.2928G>C (p.Arg976Ser)	PALB2 (R154S +7 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228022	NM_024675.4(PALB2):c.2855A>G (p.Asp952Gly)	PALB2 (D130G +7 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228021	NM_024675.4(PALB2):c.282A>C (p.Glu94Asp)	PALB2 (E74D +1 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3228020	NM_024675.4(PALB2):c.2817G>A (p.Leu939=)	PALB2	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3228019	NM_024675.4(PALB2):c.2808G>T (p.Leu936Phe)	PALB2 (L114F +7 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance

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