ClinVar Genomic variation as it relates to human health
GRCh37/hg19 10q25.1-25.3(chr10:107092654-117852548)x1
Germline
Classification
(1)
Uncertain significance
no assertion criteria provided
Somatic
No data submitted for somatic clinical impact
Somatic
No data submitted for oncogenicity
Genes
Gene | OMIM | ClinGen Gene Dosage Sensitivity Curation | Variation Viewer | Related variants | ||
---|---|---|---|---|---|---|
HI score | TS score | Within gene | All | |||
TCF7L2 | Little evidence for dosage pathogenicity | No evidence available |
GRCh38 GRCh37 |
134 | 166 | |
SHOC2 | No evidence available | No evidence available |
GRCh38 GRCh37 |
501 | 538 | |
ABLIM1 | - | - |
GRCh38 GRCh37 |
53 | 85 | |
ACSL5 | - | - |
GRCh38 GRCh37 |
31 | 68 | |
ADD3 | - | - |
GRCh38 GRCh37 |
180 | 210 | |
ADRA2A | - | - |
GRCh38 GRCh37 |
34 | 63 | |
ADRB1 | - | - |
GRCh38 GRCh37 |
35 | 64 | |
AFAP1L2 | - | - |
GRCh38 GRCh37 |
68 | 136 | |
ATRNL1 | - | - |
GRCh38 GRCh37 |
78 | 116 | |
BBIP1 | - | - |
GRCh38 GRCh37 |
81 | 111 |
There are 24 more genes affected by this variant. See the full set of genes in Variation Viewer (GRCh37) and ClinGen Dosage Sensitivity Map.
Conditions - Germline
Condition | Classification
(# of submissions) |
Review status | Last evaluated | Variation/condition record |
---|---|---|---|---|
Uncertain significance (1) |
|
Mar 1, 2021 | RCV001827678.1 |
Citations for germline classification of this variant
HelpText-mined citations for this variant ...
HelpRecord last updated Nov 05, 2022