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NM_007294.4(BRCA1):c.131G>C (p.Cys44Ser) AND Hereditary breast ovarian cancer syndrome

Germline classification:
Pathogenic (1 submission)
Last evaluated:
Jul 25, 2023
Review status:
1 star out of maximum of 4 stars
criteria provided, single submitter
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV003530163.2

Allele description [Variation Report for NM_007294.4(BRCA1):c.131G>C (p.Cys44Ser)]

NM_007294.4(BRCA1):c.131G>C (p.Cys44Ser)

Gene:
BRCA1:BRCA1 DNA repair associated [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
17q21.31
Genomic location:
Preferred name:
NM_007294.4(BRCA1):c.131G>C (p.Cys44Ser)
HGVS:
  • NC_000017.11:g.43115729C>G
  • NG_005905.2:g.102255G>C
  • NM_001407571.1:c.-58G>C
  • NM_001407581.1:c.131G>C
  • NM_001407582.1:c.131G>C
  • NM_001407583.1:c.131G>C
  • NM_001407585.1:c.131G>C
  • NM_001407587.1:c.131G>C
  • NM_001407590.1:c.131G>C
  • NM_001407591.1:c.131G>C
  • NM_001407593.1:c.131G>C
  • NM_001407594.1:c.131G>C
  • NM_001407596.1:c.131G>C
  • NM_001407597.1:c.131G>C
  • NM_001407598.1:c.131G>C
  • NM_001407602.1:c.131G>C
  • NM_001407603.1:c.131G>C
  • NM_001407605.1:c.131G>C
  • NM_001407610.1:c.131G>C
  • NM_001407611.1:c.131G>C
  • NM_001407612.1:c.131G>C
  • NM_001407613.1:c.131G>C
  • NM_001407614.1:c.131G>C
  • NM_001407615.1:c.131G>C
  • NM_001407616.1:c.131G>C
  • NM_001407617.1:c.131G>C
  • NM_001407618.1:c.131G>C
  • NM_001407619.1:c.131G>C
  • NM_001407620.1:c.131G>C
  • NM_001407621.1:c.131G>C
  • NM_001407622.1:c.131G>C
  • NM_001407623.1:c.131G>C
  • NM_001407624.1:c.131G>C
  • NM_001407625.1:c.131G>C
  • NM_001407626.1:c.131G>C
  • NM_001407627.1:c.131G>C
  • NM_001407628.1:c.131G>C
  • NM_001407629.1:c.131G>C
  • NM_001407630.1:c.131G>C
  • NM_001407631.1:c.131G>C
  • NM_001407632.1:c.131G>C
  • NM_001407633.1:c.131G>C
  • NM_001407634.1:c.131G>C
  • NM_001407635.1:c.131G>C
  • NM_001407636.1:c.131G>C
  • NM_001407637.1:c.131G>C
  • NM_001407638.1:c.131G>C
  • NM_001407639.1:c.131G>C
  • NM_001407640.1:c.131G>C
  • NM_001407641.1:c.131G>C
  • NM_001407642.1:c.131G>C
  • NM_001407644.1:c.131G>C
  • NM_001407645.1:c.131G>C
  • NM_001407646.1:c.131G>C
  • NM_001407647.1:c.131G>C
  • NM_001407648.1:c.131G>C
  • NM_001407649.1:c.131G>C
  • NM_001407652.1:c.131G>C
  • NM_001407653.1:c.131G>C
  • NM_001407654.1:c.131G>C
  • NM_001407655.1:c.131G>C
  • NM_001407656.1:c.131G>C
  • NM_001407657.1:c.131G>C
  • NM_001407658.1:c.131G>C
  • NM_001407659.1:c.131G>C
  • NM_001407660.1:c.131G>C
  • NM_001407661.1:c.131G>C
  • NM_001407662.1:c.131G>C
  • NM_001407663.1:c.131G>C
  • NM_001407664.1:c.131G>C
  • NM_001407665.1:c.131G>C
  • NM_001407666.1:c.131G>C
  • NM_001407667.1:c.131G>C
  • NM_001407668.1:c.131G>C
  • NM_001407669.1:c.131G>C
  • NM_001407670.1:c.131G>C
  • NM_001407671.1:c.131G>C
  • NM_001407672.1:c.131G>C
  • NM_001407673.1:c.131G>C
  • NM_001407674.1:c.131G>C
  • NM_001407675.1:c.131G>C
  • NM_001407676.1:c.131G>C
  • NM_001407677.1:c.131G>C
  • NM_001407678.1:c.131G>C
  • NM_001407679.1:c.131G>C
  • NM_001407680.1:c.131G>C
  • NM_001407681.1:c.131G>C
  • NM_001407682.1:c.131G>C
  • NM_001407683.1:c.131G>C
  • NM_001407684.1:c.131G>C
  • NM_001407685.1:c.131G>C
  • NM_001407686.1:c.131G>C
  • NM_001407687.1:c.131G>C
  • NM_001407688.1:c.131G>C
  • NM_001407689.1:c.131G>C
  • NM_001407690.1:c.131G>C
  • NM_001407691.1:c.131G>C
  • NM_001407694.1:c.-127G>C
  • NM_001407695.1:c.-131G>C
  • NM_001407696.1:c.-127G>C
  • NM_001407697.1:c.-11G>C
  • NM_001407724.1:c.-127G>C
  • NM_001407725.1:c.-11G>C
  • NM_001407727.1:c.-127G>C
  • NM_001407728.1:c.-11G>C
  • NM_001407729.1:c.-11G>C
  • NM_001407730.1:c.-11G>C
  • NM_001407731.1:c.-127G>C
  • NM_001407733.1:c.-127G>C
  • NM_001407734.1:c.-11G>C
  • NM_001407735.1:c.-11G>C
  • NM_001407737.1:c.-11G>C
  • NM_001407739.1:c.-11G>C
  • NM_001407740.1:c.-11G>C
  • NM_001407741.1:c.-11G>C
  • NM_001407743.1:c.-11G>C
  • NM_001407745.1:c.-11G>C
  • NM_001407746.1:c.-127G>C
  • NM_001407748.1:c.-11G>C
  • NM_001407749.1:c.-127G>C
  • NM_001407752.1:c.-11G>C
  • NM_001407838.1:c.-11G>C
  • NM_001407839.1:c.-11G>C
  • NM_001407842.1:c.-127G>C
  • NM_001407843.1:c.-127G>C
  • NM_001407844.1:c.-11G>C
  • NM_001407846.1:c.-11G>C
  • NM_001407847.1:c.-11G>C
  • NM_001407848.1:c.-11G>C
  • NM_001407850.1:c.-11G>C
  • NM_001407851.1:c.-11G>C
  • NM_001407853.1:c.-58G>C
  • NM_001407854.1:c.131G>C
  • NM_001407858.1:c.131G>C
  • NM_001407859.1:c.131G>C
  • NM_001407860.1:c.131G>C
  • NM_001407861.1:c.131G>C
  • NM_001407862.1:c.131G>C
  • NM_001407863.1:c.131G>C
  • NM_001407874.1:c.131G>C
  • NM_001407875.1:c.131G>C
  • NM_001407879.1:c.-58G>C
  • NM_001407882.1:c.-58G>C
  • NM_001407884.1:c.-58G>C
  • NM_001407885.1:c.-58G>C
  • NM_001407886.1:c.-58G>C
  • NM_001407887.1:c.-58G>C
  • NM_001407889.1:c.-174G>C
  • NM_001407894.1:c.-58G>C
  • NM_001407895.1:c.-58G>C
  • NM_001407896.1:c.-58G>C
  • NM_001407897.1:c.-58G>C
  • NM_001407899.1:c.-58G>C
  • NM_001407900.1:c.-174G>C
  • NM_001407904.1:c.-58G>C
  • NM_001407906.1:c.-58G>C
  • NM_001407907.1:c.-58G>C
  • NM_001407908.1:c.-58G>C
  • NM_001407909.1:c.-58G>C
  • NM_001407910.1:c.-58G>C
  • NM_001407915.1:c.-58G>C
  • NM_001407916.1:c.-58G>C
  • NM_001407917.1:c.-58G>C
  • NM_001407918.1:c.-58G>C
  • NM_001407919.1:c.131G>C
  • NM_001407920.1:c.-11G>C
  • NM_001407921.1:c.-11G>C
  • NM_001407922.1:c.-11G>C
  • NM_001407923.1:c.-11G>C
  • NM_001407926.1:c.-11G>C
  • NM_001407927.1:c.-11G>C
  • NM_001407930.1:c.-127G>C
  • NM_001407933.1:c.-11G>C
  • NM_001407934.1:c.-11G>C
  • NM_001407935.1:c.-11G>C
  • NM_001407937.1:c.131G>C
  • NM_001407938.1:c.131G>C
  • NM_001407939.1:c.131G>C
  • NM_001407940.1:c.131G>C
  • NM_001407941.1:c.131G>C
  • NM_001407942.1:c.-127G>C
  • NM_001407943.1:c.-11G>C
  • NM_001407944.1:c.-11G>C
  • NM_001407946.1:c.-58G>C
  • NM_001407947.1:c.-58G>C
  • NM_001407948.1:c.-58G>C
  • NM_001407949.1:c.-58G>C
  • NM_001407950.1:c.-58G>C
  • NM_001407951.1:c.-58G>C
  • NM_001407952.1:c.-58G>C
  • NM_001407953.1:c.-58G>C
  • NM_001407954.1:c.-58G>C
  • NM_001407955.1:c.-58G>C
  • NM_001407956.1:c.-58G>C
  • NM_001407957.1:c.-58G>C
  • NM_001407958.1:c.-58G>C
  • NM_001407960.1:c.-173G>C
  • NM_001407962.1:c.-173G>C
  • NM_001407964.1:c.-11G>C
  • NM_001407965.1:c.-289G>C
  • NM_001407968.1:c.131G>C
  • NM_001407969.1:c.131G>C
  • NM_001407970.1:c.131G>C
  • NM_001407971.1:c.131G>C
  • NM_001407972.1:c.131G>C
  • NM_001407973.1:c.131G>C
  • NM_001407974.1:c.131G>C
  • NM_001407975.1:c.131G>C
  • NM_001407976.1:c.131G>C
  • NM_001407977.1:c.131G>C
  • NM_001407978.1:c.131G>C
  • NM_001407979.1:c.131G>C
  • NM_001407980.1:c.131G>C
  • NM_001407981.1:c.131G>C
  • NM_001407982.1:c.131G>C
  • NM_001407983.1:c.131G>C
  • NM_001407984.1:c.131G>C
  • NM_001407985.1:c.131G>C
  • NM_001407986.1:c.131G>C
  • NM_001407990.1:c.131G>C
  • NM_001407991.1:c.131G>C
  • NM_001407992.1:c.131G>C
  • NM_001407993.1:c.131G>C
  • NM_001408392.1:c.131G>C
  • NM_001408396.1:c.131G>C
  • NM_001408397.1:c.131G>C
  • NM_001408398.1:c.131G>C
  • NM_001408399.1:c.131G>C
  • NM_001408400.1:c.131G>C
  • NM_001408401.1:c.131G>C
  • NM_001408402.1:c.131G>C
  • NM_001408403.1:c.131G>C
  • NM_001408404.1:c.131G>C
  • NM_001408406.1:c.131G>C
  • NM_001408407.1:c.131G>C
  • NM_001408408.1:c.131G>C
  • NM_001408409.1:c.131G>C
  • NM_001408410.1:c.-11G>C
  • NM_001408411.1:c.131G>C
  • NM_001408412.1:c.131G>C
  • NM_001408413.1:c.131G>C
  • NM_001408414.1:c.131G>C
  • NM_001408415.1:c.131G>C
  • NM_001408416.1:c.131G>C
  • NM_001408418.1:c.131G>C
  • NM_001408419.1:c.131G>C
  • NM_001408420.1:c.131G>C
  • NM_001408421.1:c.131G>C
  • NM_001408422.1:c.131G>C
  • NM_001408423.1:c.131G>C
  • NM_001408424.1:c.131G>C
  • NM_001408425.1:c.131G>C
  • NM_001408426.1:c.131G>C
  • NM_001408427.1:c.131G>C
  • NM_001408428.1:c.131G>C
  • NM_001408429.1:c.131G>C
  • NM_001408430.1:c.131G>C
  • NM_001408431.1:c.131G>C
  • NM_001408432.1:c.131G>C
  • NM_001408433.1:c.131G>C
  • NM_001408434.1:c.131G>C
  • NM_001408435.1:c.131G>C
  • NM_001408436.1:c.131G>C
  • NM_001408437.1:c.131G>C
  • NM_001408438.1:c.131G>C
  • NM_001408439.1:c.131G>C
  • NM_001408440.1:c.131G>C
  • NM_001408441.1:c.131G>C
  • NM_001408442.1:c.131G>C
  • NM_001408443.1:c.131G>C
  • NM_001408444.1:c.131G>C
  • NM_001408445.1:c.131G>C
  • NM_001408446.1:c.131G>C
  • NM_001408447.1:c.131G>C
  • NM_001408448.1:c.131G>C
  • NM_001408450.1:c.131G>C
  • NM_001408452.1:c.-11G>C
  • NM_001408453.1:c.-11G>C
  • NM_001408455.1:c.-127G>C
  • NM_001408456.1:c.-127G>C
  • NM_001408458.1:c.-11G>C
  • NM_001408462.1:c.-11G>C
  • NM_001408463.1:c.-11G>C
  • NM_001408465.1:c.-131G>C
  • NM_001408466.1:c.-11G>C
  • NM_001408468.1:c.-127G>C
  • NM_001408469.1:c.-11G>C
  • NM_001408470.1:c.-11G>C
  • NM_001408472.1:c.131G>C
  • NM_001408473.1:c.131G>C
  • NM_001408474.1:c.131G>C
  • NM_001408475.1:c.131G>C
  • NM_001408476.1:c.131G>C
  • NM_001408478.1:c.-58G>C
  • NM_001408479.1:c.-58G>C
  • NM_001408480.1:c.-58G>C
  • NM_001408481.1:c.-58G>C
  • NM_001408482.1:c.-58G>C
  • NM_001408483.1:c.-58G>C
  • NM_001408484.1:c.-58G>C
  • NM_001408485.1:c.-58G>C
  • NM_001408489.1:c.-58G>C
  • NM_001408490.1:c.-58G>C
  • NM_001408491.1:c.-58G>C
  • NM_001408492.1:c.-174G>C
  • NM_001408493.1:c.-58G>C
  • NM_001408494.1:c.131G>C
  • NM_001408495.1:c.131G>C
  • NM_001408497.1:c.-11G>C
  • NM_001408499.1:c.-11G>C
  • NM_001408500.1:c.-11G>C
  • NM_001408501.1:c.-127G>C
  • NM_001408502.1:c.-58G>C
  • NM_001408503.1:c.-11G>C
  • NM_001408504.1:c.-11G>C
  • NM_001408505.1:c.-11G>C
  • NM_001408506.1:c.-58G>C
  • NM_001408507.1:c.-58G>C
  • NM_001408508.1:c.-58G>C
  • NM_001408509.1:c.-58G>C
  • NM_001408510.1:c.-173G>C
  • NM_001408512.1:c.-173G>C
  • NM_001408513.1:c.-58G>C
  • NM_001408514.1:c.-58G>C
  • NM_007294.4:c.131G>CMANE SELECT
  • NM_007297.4:c.-8+8288G>C
  • NM_007298.4:c.131G>C
  • NM_007299.4:c.131G>C
  • NM_007300.4:c.131G>C
  • NM_007304.2:c.131G>C
  • NP_001394510.1:p.Cys44Ser
  • NP_001394511.1:p.Cys44Ser
  • NP_001394512.1:p.Cys44Ser
  • NP_001394514.1:p.Cys44Ser
  • NP_001394516.1:p.Cys44Ser
  • NP_001394519.1:p.Cys44Ser
  • NP_001394520.1:p.Cys44Ser
  • NP_001394522.1:p.Cys44Ser
  • NP_001394523.1:p.Cys44Ser
  • NP_001394525.1:p.Cys44Ser
  • NP_001394526.1:p.Cys44Ser
  • NP_001394527.1:p.Cys44Ser
  • NP_001394531.1:p.Cys44Ser
  • NP_001394532.1:p.Cys44Ser
  • NP_001394534.1:p.Cys44Ser
  • NP_001394539.1:p.Cys44Ser
  • NP_001394540.1:p.Cys44Ser
  • NP_001394541.1:p.Cys44Ser
  • NP_001394542.1:p.Cys44Ser
  • NP_001394543.1:p.Cys44Ser
  • NP_001394544.1:p.Cys44Ser
  • NP_001394545.1:p.Cys44Ser
  • NP_001394546.1:p.Cys44Ser
  • NP_001394547.1:p.Cys44Ser
  • NP_001394548.1:p.Cys44Ser
  • NP_001394549.1:p.Cys44Ser
  • NP_001394550.1:p.Cys44Ser
  • NP_001394551.1:p.Cys44Ser
  • NP_001394552.1:p.Cys44Ser
  • NP_001394553.1:p.Cys44Ser
  • NP_001394554.1:p.Cys44Ser
  • NP_001394555.1:p.Cys44Ser
  • NP_001394556.1:p.Cys44Ser
  • NP_001394557.1:p.Cys44Ser
  • NP_001394558.1:p.Cys44Ser
  • NP_001394559.1:p.Cys44Ser
  • NP_001394560.1:p.Cys44Ser
  • NP_001394561.1:p.Cys44Ser
  • NP_001394562.1:p.Cys44Ser
  • NP_001394563.1:p.Cys44Ser
  • NP_001394564.1:p.Cys44Ser
  • NP_001394565.1:p.Cys44Ser
  • NP_001394566.1:p.Cys44Ser
  • NP_001394567.1:p.Cys44Ser
  • NP_001394568.1:p.Cys44Ser
  • NP_001394569.1:p.Cys44Ser
  • NP_001394570.1:p.Cys44Ser
  • NP_001394571.1:p.Cys44Ser
  • NP_001394573.1:p.Cys44Ser
  • NP_001394574.1:p.Cys44Ser
  • NP_001394575.1:p.Cys44Ser
  • NP_001394576.1:p.Cys44Ser
  • NP_001394577.1:p.Cys44Ser
  • NP_001394578.1:p.Cys44Ser
  • NP_001394581.1:p.Cys44Ser
  • NP_001394582.1:p.Cys44Ser
  • NP_001394583.1:p.Cys44Ser
  • NP_001394584.1:p.Cys44Ser
  • NP_001394585.1:p.Cys44Ser
  • NP_001394586.1:p.Cys44Ser
  • NP_001394587.1:p.Cys44Ser
  • NP_001394588.1:p.Cys44Ser
  • NP_001394589.1:p.Cys44Ser
  • NP_001394590.1:p.Cys44Ser
  • NP_001394591.1:p.Cys44Ser
  • NP_001394592.1:p.Cys44Ser
  • NP_001394593.1:p.Cys44Ser
  • NP_001394594.1:p.Cys44Ser
  • NP_001394595.1:p.Cys44Ser
  • NP_001394596.1:p.Cys44Ser
  • NP_001394597.1:p.Cys44Ser
  • NP_001394598.1:p.Cys44Ser
  • NP_001394599.1:p.Cys44Ser
  • NP_001394600.1:p.Cys44Ser
  • NP_001394601.1:p.Cys44Ser
  • NP_001394602.1:p.Cys44Ser
  • NP_001394603.1:p.Cys44Ser
  • NP_001394604.1:p.Cys44Ser
  • NP_001394605.1:p.Cys44Ser
  • NP_001394606.1:p.Cys44Ser
  • NP_001394607.1:p.Cys44Ser
  • NP_001394608.1:p.Cys44Ser
  • NP_001394609.1:p.Cys44Ser
  • NP_001394610.1:p.Cys44Ser
  • NP_001394611.1:p.Cys44Ser
  • NP_001394612.1:p.Cys44Ser
  • NP_001394613.1:p.Cys44Ser
  • NP_001394614.1:p.Cys44Ser
  • NP_001394615.1:p.Cys44Ser
  • NP_001394616.1:p.Cys44Ser
  • NP_001394617.1:p.Cys44Ser
  • NP_001394618.1:p.Cys44Ser
  • NP_001394619.1:p.Cys44Ser
  • NP_001394620.1:p.Cys44Ser
  • NP_001394783.1:p.Cys44Ser
  • NP_001394787.1:p.Cys44Ser
  • NP_001394788.1:p.Cys44Ser
  • NP_001394789.1:p.Cys44Ser
  • NP_001394790.1:p.Cys44Ser
  • NP_001394791.1:p.Cys44Ser
  • NP_001394792.1:p.Cys44Ser
  • NP_001394803.1:p.Cys44Ser
  • NP_001394804.1:p.Cys44Ser
  • NP_001394848.1:p.Cys44Ser
  • NP_001394866.1:p.Cys44Ser
  • NP_001394867.1:p.Cys44Ser
  • NP_001394868.1:p.Cys44Ser
  • NP_001394869.1:p.Cys44Ser
  • NP_001394870.1:p.Cys44Ser
  • NP_001394897.1:p.Cys44Ser
  • NP_001394898.1:p.Cys44Ser
  • NP_001394899.1:p.Cys44Ser
  • NP_001394900.1:p.Cys44Ser
  • NP_001394901.1:p.Cys44Ser
  • NP_001394902.1:p.Cys44Ser
  • NP_001394903.1:p.Cys44Ser
  • NP_001394904.1:p.Cys44Ser
  • NP_001394905.1:p.Cys44Ser
  • NP_001394906.1:p.Cys44Ser
  • NP_001394907.1:p.Cys44Ser
  • NP_001394908.1:p.Cys44Ser
  • NP_001394909.1:p.Cys44Ser
  • NP_001394910.1:p.Cys44Ser
  • NP_001394911.1:p.Cys44Ser
  • NP_001394912.1:p.Cys44Ser
  • NP_001394913.1:p.Cys44Ser
  • NP_001394914.1:p.Cys44Ser
  • NP_001394915.1:p.Cys44Ser
  • NP_001394919.1:p.Cys44Ser
  • NP_001394920.1:p.Cys44Ser
  • NP_001394921.1:p.Cys44Ser
  • NP_001394922.1:p.Cys44Ser
  • NP_001395321.1:p.Cys44Ser
  • NP_001395325.1:p.Cys44Ser
  • NP_001395326.1:p.Cys44Ser
  • NP_001395327.1:p.Cys44Ser
  • NP_001395328.1:p.Cys44Ser
  • NP_001395329.1:p.Cys44Ser
  • NP_001395330.1:p.Cys44Ser
  • NP_001395331.1:p.Cys44Ser
  • NP_001395332.1:p.Cys44Ser
  • NP_001395333.1:p.Cys44Ser
  • NP_001395335.1:p.Cys44Ser
  • NP_001395336.1:p.Cys44Ser
  • NP_001395337.1:p.Cys44Ser
  • NP_001395338.1:p.Cys44Ser
  • NP_001395340.1:p.Cys44Ser
  • NP_001395341.1:p.Cys44Ser
  • NP_001395342.1:p.Cys44Ser
  • NP_001395343.1:p.Cys44Ser
  • NP_001395344.1:p.Cys44Ser
  • NP_001395345.1:p.Cys44Ser
  • NP_001395347.1:p.Cys44Ser
  • NP_001395348.1:p.Cys44Ser
  • NP_001395349.1:p.Cys44Ser
  • NP_001395350.1:p.Cys44Ser
  • NP_001395351.1:p.Cys44Ser
  • NP_001395352.1:p.Cys44Ser
  • NP_001395353.1:p.Cys44Ser
  • NP_001395354.1:p.Cys44Ser
  • NP_001395355.1:p.Cys44Ser
  • NP_001395356.1:p.Cys44Ser
  • NP_001395357.1:p.Cys44Ser
  • NP_001395358.1:p.Cys44Ser
  • NP_001395359.1:p.Cys44Ser
  • NP_001395360.1:p.Cys44Ser
  • NP_001395361.1:p.Cys44Ser
  • NP_001395362.1:p.Cys44Ser
  • NP_001395363.1:p.Cys44Ser
  • NP_001395364.1:p.Cys44Ser
  • NP_001395365.1:p.Cys44Ser
  • NP_001395366.1:p.Cys44Ser
  • NP_001395367.1:p.Cys44Ser
  • NP_001395368.1:p.Cys44Ser
  • NP_001395369.1:p.Cys44Ser
  • NP_001395370.1:p.Cys44Ser
  • NP_001395371.1:p.Cys44Ser
  • NP_001395372.1:p.Cys44Ser
  • NP_001395373.1:p.Cys44Ser
  • NP_001395374.1:p.Cys44Ser
  • NP_001395375.1:p.Cys44Ser
  • NP_001395376.1:p.Cys44Ser
  • NP_001395377.1:p.Cys44Ser
  • NP_001395379.1:p.Cys44Ser
  • NP_001395401.1:p.Cys44Ser
  • NP_001395402.1:p.Cys44Ser
  • NP_001395403.1:p.Cys44Ser
  • NP_001395404.1:p.Cys44Ser
  • NP_001395405.1:p.Cys44Ser
  • NP_001395423.1:p.Cys44Ser
  • NP_001395424.1:p.Cys44Ser
  • NP_009225.1:p.Cys44Ser
  • NP_009225.1:p.Cys44Ser
  • NP_009229.2:p.Cys44Ser
  • NP_009229.2:p.Cys44Ser
  • NP_009230.2:p.Cys44Ser
  • NP_009231.2:p.Cys44Ser
  • NP_009235.2:p.Cys44Ser
  • LRG_292t1:c.131G>C
  • LRG_292:g.102255G>C
  • LRG_292p1:p.Cys44Ser
  • NC_000017.10:g.41267746C>G
  • NC_000017.10:g.41267746C>G
  • NM_007294.3:c.131G>C
  • NM_007298.3:c.131G>C
  • NR_027676.2:n.333G>C
Protein change:
C44S
Links:
dbSNP: rs80357446
NCBI 1000 Genomes Browser:
rs80357446
Molecular consequence:
  • NM_007297.4:c.-8+8288G>C - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407581.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407582.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407583.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407585.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407587.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407590.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407591.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407593.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407594.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407596.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407597.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407598.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407602.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407603.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407605.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407610.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407611.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407612.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407613.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407614.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407615.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407616.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407617.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407618.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407619.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407620.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407621.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407622.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407623.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407624.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407625.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407626.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407627.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407628.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407629.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407630.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407631.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407632.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407633.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407634.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407635.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407636.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407637.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407638.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407639.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407640.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407641.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407642.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407644.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407645.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407646.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407647.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407648.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407649.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407652.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407653.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407654.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407655.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407656.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407657.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407658.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407659.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407660.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407661.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407662.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407663.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407664.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407665.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407666.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407667.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407668.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407669.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407670.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407671.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407672.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407673.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407674.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407675.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407676.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407677.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407678.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407679.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407680.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407681.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407682.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407683.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407684.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407685.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407686.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407687.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407688.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407689.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407690.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407691.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407854.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407858.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407859.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407860.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407861.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407862.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407863.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407874.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407875.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407919.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407937.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407938.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407939.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407940.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407941.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407968.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407969.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407970.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407971.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407972.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407973.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407974.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407975.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407976.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407977.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407978.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407979.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407980.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407981.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407982.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407983.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407984.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407985.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407986.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407990.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407991.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407992.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001407993.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408392.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408396.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408397.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408398.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408399.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408400.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408401.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408402.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408403.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408404.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408406.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408407.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408408.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408409.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408411.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408412.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408413.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408414.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408415.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408416.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408418.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408419.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408420.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408421.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408422.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408423.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408424.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408425.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408426.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408427.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408428.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408429.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408430.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408431.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408432.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408433.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408434.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408435.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408436.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408437.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408438.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408439.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408440.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408441.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408442.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408443.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408444.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408445.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408446.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408447.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408448.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408450.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408472.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408473.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408474.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408475.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408476.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408494.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001408495.1:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_007294.4:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_007298.4:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_007299.4:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_007300.4:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NM_007304.2:c.131G>C - missense variant - [Sequence Ontology: SO:0001583]
  • NR_027676.2:n.333G>C - non-coding transcript variant - [Sequence Ontology: SO:0001619]
Functional consequence:
functionally_abnormal [Sequence Ontology: SO:0002218] - Comment(s)

Condition(s)

Name:
Hereditary breast ovarian cancer syndrome
Synonyms:
Hereditary breast and ovarian cancer syndrome; Hereditary breast and ovarian cancer; Hereditary breast and ovarian cancer syndrome (HBOC); See all synonyms [MedGen]
Identifiers:
MONDO: MONDO:0003582; MeSH: D061325; MedGen: C0677776; Orphanet: 145

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Assertion and evidence details

Help
Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV004306662Labcorp Genetics (formerly Invitae), Labcorp
criteria provided, single submitter

(Invitae Variant Classification Sherloc (09022015))		Pathogenic
(Jul 25, 2023) 		germlineclinical testing

PubMed (14)
[See all records that cite these PMIDs]

Help

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineunknownnot providednot providednot providednot providednot providedclinical testing

Citations

PubMed

Variation of breast cancer risk among BRCA1/2 carriers.

Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL.

JAMA. 2008 Jan 9;299(2):194-201. doi: 10.1001/jama.2007.55-a.

PubMed [citation]
PMID:
18182601
PMCID:
PMC2714486

A common Greenlandic Inuit BRCA1 RING domain founder mutation.

Hansen TV, Ejlertsen B, Albrechtsen A, Bergsten E, Bjerregaard P, Hansen T, Myrhøj T, Nielsen PB, Timmermans-Wielenga V, Andersen MK, Jønson L, Nielsen FC.

Breast Cancer Res Treat. 2009 May;115(1):69-76. doi: 10.1007/s10549-008-0060-z. Epub 2008 May 26.

PubMed [citation]
PMID:
18500671
See all PubMed Citations (14)

Details of each submission

From Labcorp Genetics (formerly Invitae), Labcorp, SCV004306662.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedclinical testing PubMed (14)

Description

This sequence change replaces cysteine, which is neutral and slightly polar, with serine, which is neutral and polar, at codon 44 of the BRCA1 protein (p.Cys44Ser). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individual(s) with breast and ovarian cancer (PMID: 18182601, 18500671, 19543972, 20104584, 35858847). ClinVar contains an entry for this variant (Variation ID: 868170). Advanced modeling performed at Invitae incorporating data from internal and/or published experimental studies (PMID: 30209399) indicates that this missense variant is expected to disrupt BRCA1 function. This variant disrupts the p.Cys44 amino acid residue in BRCA1. Other variant(s) that disrupt this residue have been determined to be pathogenic (PMID: 16403807, 20103620, 21725363, 21922593, 21990134, 23161852, 27272900). This suggests that this residue is clinically significant, and that variants that disrupt this residue are likely to be disease-causing. For these reasons, this variant has been classified as Pathogenic.

#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineunknownnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Oct 8, 2024