U.S. flag

An official website of the United States government

NM_000546.6(TP53):c.376-12del AND Prostate cancer, hereditary, 1

Germline classification:
Uncertain significance (1 submission)
Last evaluated:
Jan 1, 2024
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV003484962.1

Allele description [Variation Report for NM_000546.6(TP53):c.376-12del]

NM_000546.6(TP53):c.376-12del

Gene:
TP53:tumor protein p53 [Gene - OMIM - HGNC]
Variant type:
Deletion
Cytogenetic location:
17p13.1
Genomic location:
Preferred name:
NM_000546.6(TP53):c.376-12del
HGVS:
  • NC_000017.11:g.7675249del
  • NG_017013.2:g.17303del
  • NM_000546.6:c.376-12delMANE SELECT
  • NM_001126112.3:c.376-12del
  • NM_001126113.3:c.376-12del
  • NM_001126114.3:c.376-12del
  • NM_001126115.1:c.-34delC
  • NM_001126116.1:c.-34delC
  • NM_001126117.1:c.-34delC
  • NM_001126118.2:c.259-12del
  • NM_001276695.3:c.259-12del
  • NM_001276696.3:c.259-12del
  • NM_001276697.1:c.-115delC
  • NM_001276698.1:c.-115delC
  • NM_001276699.1:c.-115delC
  • NM_001276760.3:c.259-12del
  • NM_001276761.3:c.259-12del
  • NM_001407262.1:c.376-12del
  • NM_001407263.1:c.259-12del
  • NM_001407264.1:c.376-12del
  • NM_001407265.1:c.259-12del
  • NM_001407266.1:c.376-12del
  • NM_001407267.1:c.259-12del
  • NM_001407268.1:c.376-12del
  • NM_001407269.1:c.259-12del
  • NM_001407270.1:c.376-12del
  • NM_001407271.1:c.259-12del
  • LRG_321t5:c.-34del
  • LRG_321t6:c.-34del
  • LRG_321t7:c.-34del
  • LRG_321:g.17303del
  • NC_000017.10:g.7578567del
  • NM_000546.6:c.376-12delCMANE SELECT
Molecular consequence:
  • NM_000546.6:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001126112.3:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001126113.3:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001126114.3:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001126118.2:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001276695.3:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001276696.3:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001276760.3:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001276761.3:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407262.1:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407263.1:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407264.1:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407265.1:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407266.1:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407267.1:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407268.1:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407269.1:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407270.1:c.376-12del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001407271.1:c.259-12del - intron variant - [Sequence Ontology: SO:0001627]

Condition(s)

Name:
Prostate cancer, hereditary, 1 (HPC1)
Identifiers:
MONDO: MONDO:0011098; MedGen: C4722327; Orphanet: 1331; OMIM: 601518

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV004232145Laboratory of Virology, Oncology, Biosciences and Environment, Faculty of Sciences and Techniques, Mohammedia- University Hassan II of Casablanca
no assertion criteria provided
Uncertain significance
(Jan 1, 2024)
germlineclinical testing

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineyesnot providednot providednot providednot providednot providedclinical testing

Details of each submission

From Laboratory of Virology, Oncology, Biosciences and Environment, Faculty of Sciences and Techniques, Mohammedia- University Hassan II of Casablanca, SCV004232145.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedclinical testingnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineyesnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Jun 17, 2024