NM_007294.4(BRCA1):c.5238C>G (p.His1746Gln) AND Hereditary breast ovarian cancer syndrome
- Germline classification:
- Uncertain significance (1 submission)
- Last evaluated:
- Sep 12, 2023
- Review status:
- 1 star out of maximum of 4 starscriteria provided, single submitter
- Somatic classification
of clinical impact: - None
- Review status:
- (0/4) 0 stars out of maximum of 4 starsno assertion criteria provided
- Somatic classification
of oncogenicity: - None
- Review status:
- (0/4) 0 stars out of maximum of 4 starsno assertion criteria provided
- Record status:
- current
- Accession:
- RCV002517619.3
Allele description [Variation Report for NM_007294.4(BRCA1):c.5238C>G (p.His1746Gln)]
NM_007294.4(BRCA1):c.5238C>G (p.His1746Gln)
- Gene:
- BRCA1:BRCA1 DNA repair associated [Gene - OMIM - HGNC]
- Variant type:
- single nucleotide variant
- Cytogenetic location:
- 17q21.31
- Genomic location:
- Preferred name:
- NM_007294.4(BRCA1):c.5238C>G (p.His1746Gln)
- HGVS:
- NC_000017.11:g.43057091G>C
- NG_005905.2:g.160893C>G
- NM_001407571.1:c.5025C>G
- NM_001407581.1:c.5304C>G
- NM_001407582.1:c.5304C>G
- NM_001407583.1:c.5301C>G
- NM_001407585.1:c.5301C>G
- NM_001407587.1:c.5301C>G
- NM_001407590.1:c.5298C>G
- NM_001407591.1:c.5298C>G
- NM_001407593.1:c.5238C>G
- NM_001407594.1:c.5238C>G
- NM_001407596.1:c.5238C>G
- NM_001407597.1:c.5238C>G
- NM_001407598.1:c.5238C>G
- NM_001407602.1:c.5238C>G
- NM_001407603.1:c.5238C>G
- NM_001407605.1:c.5238C>G
- NM_001407610.1:c.5235C>G
- NM_001407611.1:c.5235C>G
- NM_001407612.1:c.5235C>G
- NM_001407613.1:c.5235C>G
- NM_001407614.1:c.5235C>G
- NM_001407615.1:c.5235C>G
- NM_001407616.1:c.5235C>G
- NM_001407617.1:c.5235C>G
- NM_001407618.1:c.5235C>G
- NM_001407619.1:c.5235C>G
- NM_001407620.1:c.5235C>G
- NM_001407621.1:c.5235C>G
- NM_001407622.1:c.5235C>G
- NM_001407623.1:c.5235C>G
- NM_001407624.1:c.5235C>G
- NM_001407625.1:c.5235C>G
- NM_001407626.1:c.5235C>G
- NM_001407627.1:c.5232C>G
- NM_001407628.1:c.5232C>G
- NM_001407629.1:c.5232C>G
- NM_001407630.1:c.5232C>G
- NM_001407631.1:c.5232C>G
- NM_001407632.1:c.5232C>G
- NM_001407633.1:c.5232C>G
- NM_001407634.1:c.5232C>G
- NM_001407635.1:c.5232C>G
- NM_001407636.1:c.5232C>G
- NM_001407637.1:c.5232C>G
- NM_001407638.1:c.5232C>G
- NM_001407639.1:c.5232C>G
- NM_001407640.1:c.5232C>G
- NM_001407641.1:c.5232C>G
- NM_001407642.1:c.5232C>G
- NM_001407644.1:c.5229C>G
- NM_001407645.1:c.5229C>G
- NM_001407646.1:c.5226C>G
- NM_001407647.1:c.5223C>G
- NM_001407648.1:c.5181C>G
- NM_001407649.1:c.5178C>G
- NM_001407652.1:c.5160C>G
- NM_001407653.1:c.5160C>G
- NM_001407654.1:c.5160C>G
- NM_001407655.1:c.5160C>G
- NM_001407656.1:c.5157C>G
- NM_001407657.1:c.5157C>G
- NM_001407658.1:c.5157C>G
- NM_001407659.1:c.5154C>G
- NM_001407660.1:c.5154C>G
- NM_001407661.1:c.5154C>G
- NM_001407662.1:c.5154C>G
- NM_001407663.1:c.5154C>G
- NM_001407664.1:c.5115C>G
- NM_001407665.1:c.5115C>G
- NM_001407666.1:c.5115C>G
- NM_001407667.1:c.5115C>G
- NM_001407668.1:c.5115C>G
- NM_001407669.1:c.5115C>G
- NM_001407670.1:c.5112C>G
- NM_001407671.1:c.5112C>G
- NM_001407672.1:c.5112C>G
- NM_001407673.1:c.5112C>G
- NM_001407674.1:c.5112C>G
- NM_001407675.1:c.5112C>G
- NM_001407676.1:c.5112C>G
- NM_001407677.1:c.5112C>G
- NM_001407678.1:c.5112C>G
- NM_001407679.1:c.5112C>G
- NM_001407680.1:c.5112C>G
- NM_001407681.1:c.5109C>G
- NM_001407682.1:c.5109C>G
- NM_001407683.1:c.5109C>G
- NM_001407684.1:c.5238C>G
- NM_001407685.1:c.5109C>G
- NM_001407686.1:c.5109C>G
- NM_001407687.1:c.5109C>G
- NM_001407688.1:c.5109C>G
- NM_001407689.1:c.5109C>G
- NM_001407690.1:c.5106C>G
- NM_001407691.1:c.5106C>G
- NM_001407692.1:c.5097C>G
- NM_001407694.1:c.5097C>G
- NM_001407695.1:c.5097C>G
- NM_001407696.1:c.5097C>G
- NM_001407697.1:c.5097C>G
- NM_001407698.1:c.5097C>G
- NM_001407724.1:c.5097C>G
- NM_001407725.1:c.5097C>G
- NM_001407726.1:c.5097C>G
- NM_001407727.1:c.5097C>G
- NM_001407728.1:c.5097C>G
- NM_001407729.1:c.5097C>G
- NM_001407730.1:c.5097C>G
- NM_001407731.1:c.5097C>G
- NM_001407732.1:c.5094C>G
- NM_001407733.1:c.5094C>G
- NM_001407734.1:c.5094C>G
- NM_001407735.1:c.5094C>G
- NM_001407736.1:c.5094C>G
- NM_001407737.1:c.5094C>G
- NM_001407738.1:c.5094C>G
- NM_001407739.1:c.5094C>G
- NM_001407740.1:c.5094C>G
- NM_001407741.1:c.5094C>G
- NM_001407742.1:c.5094C>G
- NM_001407743.1:c.5094C>G
- NM_001407744.1:c.5094C>G
- NM_001407745.1:c.5094C>G
- NM_001407746.1:c.5094C>G
- NM_001407747.1:c.5094C>G
- NM_001407748.1:c.5094C>G
- NM_001407749.1:c.5094C>G
- NM_001407750.1:c.5094C>G
- NM_001407751.1:c.5094C>G
- NM_001407752.1:c.5094C>G
- NM_001407838.1:c.5091C>G
- NM_001407839.1:c.5091C>G
- NM_001407841.1:c.5091C>G
- NM_001407842.1:c.5091C>G
- NM_001407843.1:c.5091C>G
- NM_001407844.1:c.5091C>G
- NM_001407845.1:c.5091C>G
- NM_001407846.1:c.5091C>G
- NM_001407847.1:c.5091C>G
- NM_001407848.1:c.5091C>G
- NM_001407849.1:c.5091C>G
- NM_001407850.1:c.5091C>G
- NM_001407851.1:c.5091C>G
- NM_001407852.1:c.5091C>G
- NM_001407853.1:c.5091C>G
- NM_001407854.1:c.5238C>G
- NM_001407858.1:c.5235C>G
- NM_001407859.1:c.5235C>G
- NM_001407860.1:c.5235C>G
- NM_001407861.1:c.5232C>G
- NM_001407862.1:c.5037C>G
- NM_001407863.1:c.5034C>G
- NM_001407874.1:c.5031C>G
- NM_001407875.1:c.5031C>G
- NM_001407879.1:c.5028C>G
- NM_001407881.1:c.5028C>G
- NM_001407882.1:c.5028C>G
- NM_001407884.1:c.5028C>G
- NM_001407885.1:c.5028C>G
- NM_001407886.1:c.5028C>G
- NM_001407887.1:c.5028C>G
- NM_001407889.1:c.5028C>G
- NM_001407894.1:c.5025C>G
- NM_001407895.1:c.5025C>G
- NM_001407896.1:c.5025C>G
- NM_001407897.1:c.5025C>G
- NM_001407898.1:c.5025C>G
- NM_001407899.1:c.5025C>G
- NM_001407900.1:c.5025C>G
- NM_001407902.1:c.5025C>G
- NM_001407904.1:c.5025C>G
- NM_001407906.1:c.5025C>G
- NM_001407907.1:c.5025C>G
- NM_001407908.1:c.5025C>G
- NM_001407909.1:c.5025C>G
- NM_001407910.1:c.5025C>G
- NM_001407915.1:c.5022C>G
- NM_001407916.1:c.5022C>G
- NM_001407917.1:c.5022C>G
- NM_001407918.1:c.5022C>G
- NM_001407919.1:c.5115C>G
- NM_001407920.1:c.4974C>G
- NM_001407921.1:c.4974C>G
- NM_001407922.1:c.4974C>G
- NM_001407923.1:c.4974C>G
- NM_001407924.1:c.4974C>G
- NM_001407925.1:c.4974C>G
- NM_001407926.1:c.4974C>G
- NM_001407927.1:c.4971C>G
- NM_001407928.1:c.4971C>G
- NM_001407929.1:c.4971C>G
- NM_001407930.1:c.4971C>G
- NM_001407931.1:c.4971C>G
- NM_001407932.1:c.4971C>G
- NM_001407933.1:c.4971C>G
- NM_001407934.1:c.4968C>G
- NM_001407935.1:c.4968C>G
- NM_001407936.1:c.4968C>G
- NM_001407937.1:c.5115C>G
- NM_001407938.1:c.5115C>G
- NM_001407939.1:c.5112C>G
- NM_001407940.1:c.5112C>G
- NM_001407941.1:c.5109C>G
- NM_001407942.1:c.5097C>G
- NM_001407943.1:c.5094C>G
- NM_001407944.1:c.5094C>G
- NM_001407945.1:c.5094C>G
- NM_001407946.1:c.4905C>G
- NM_001407947.1:c.4905C>G
- NM_001407948.1:c.4905C>G
- NM_001407949.1:c.4905C>G
- NM_001407950.1:c.4902C>G
- NM_001407951.1:c.4902C>G
- NM_001407952.1:c.4902C>G
- NM_001407953.1:c.4902C>G
- NM_001407954.1:c.4902C>G
- NM_001407955.1:c.4902C>G
- NM_001407956.1:c.4899C>G
- NM_001407957.1:c.4899C>G
- NM_001407958.1:c.4899C>G
- NM_001407959.1:c.4857C>G
- NM_001407960.1:c.4854C>G
- NM_001407962.1:c.4854C>G
- NM_001407963.1:c.4851C>G
- NM_001407964.1:c.4776C>G
- NM_001407965.1:c.4731C>G
- NM_001407966.1:c.4350C>G
- NM_001407967.1:c.4347C>G
- NM_001407968.1:c.2634C>G
- NM_001407969.1:c.2631C>G
- NM_001407970.1:c.1995C>G
- NM_001407971.1:c.1995C>G
- NM_001407972.1:c.1992C>G
- NM_001407973.1:c.1929C>G
- NM_001407974.1:c.1929C>G
- NM_001407975.1:c.1929C>G
- NM_001407976.1:c.1929C>G
- NM_001407977.1:c.1929C>G
- NM_001407978.1:c.1929C>G
- NM_001407979.1:c.1926C>G
- NM_001407980.1:c.1926C>G
- NM_001407981.1:c.1926C>G
- NM_001407982.1:c.1926C>G
- NM_001407983.1:c.1926C>G
- NM_001407984.1:c.1926C>G
- NM_001407985.1:c.1926C>G
- NM_001407986.1:c.1926C>G
- NM_001407990.1:c.1926C>G
- NM_001407991.1:c.1926C>G
- NM_001407992.1:c.1926C>G
- NM_001407993.1:c.1926C>G
- NM_001408392.1:c.1923C>G
- NM_001408396.1:c.1923C>G
- NM_001408397.1:c.1923C>G
- NM_001408398.1:c.1923C>G
- NM_001408399.1:c.1923C>G
- NM_001408400.1:c.1923C>G
- NM_001408401.1:c.1923C>G
- NM_001408402.1:c.1923C>G
- NM_001408403.1:c.1923C>G
- NM_001408404.1:c.1923C>G
- NM_001408406.1:c.1920C>G
- NM_001408407.1:c.1920C>G
- NM_001408408.1:c.1920C>G
- NM_001408409.1:c.1917C>G
- NM_001408410.1:c.1854C>G
- NM_001408411.1:c.1851C>G
- NM_001408412.1:c.1848C>G
- NM_001408413.1:c.1848C>G
- NM_001408414.1:c.1848C>G
- NM_001408415.1:c.1848C>G
- NM_001408416.1:c.1848C>G
- NM_001408418.1:c.1812C>G
- NM_001408419.1:c.1812C>G
- NM_001408420.1:c.1812C>G
- NM_001408421.1:c.1809C>G
- NM_001408422.1:c.1809C>G
- NM_001408423.1:c.1809C>G
- NM_001408424.1:c.1809C>G
- NM_001408425.1:c.1806C>G
- NM_001408426.1:c.1806C>G
- NM_001408427.1:c.1806C>G
- NM_001408428.1:c.1806C>G
- NM_001408429.1:c.1806C>G
- NM_001408430.1:c.1806C>G
- NM_001408431.1:c.1806C>G
- NM_001408432.1:c.1803C>G
- NM_001408433.1:c.1803C>G
- NM_001408434.1:c.1803C>G
- NM_001408435.1:c.1803C>G
- NM_001408436.1:c.1803C>G
- NM_001408437.1:c.1803C>G
- NM_001408438.1:c.1803C>G
- NM_001408439.1:c.1803C>G
- NM_001408440.1:c.1803C>G
- NM_001408441.1:c.1803C>G
- NM_001408442.1:c.1803C>G
- NM_001408443.1:c.1803C>G
- NM_001408444.1:c.1803C>G
- NM_001408445.1:c.1800C>G
- NM_001408446.1:c.1800C>G
- NM_001408447.1:c.1800C>G
- NM_001408448.1:c.1800C>G
- NM_001408450.1:c.1800C>G
- NM_001408451.1:c.1794C>G
- NM_001408452.1:c.1788C>G
- NM_001408453.1:c.1788C>G
- NM_001408454.1:c.1788C>G
- NM_001408455.1:c.1788C>G
- NM_001408456.1:c.1788C>G
- NM_001408457.1:c.1788C>G
- NM_001408458.1:c.1785C>G
- NM_001408459.1:c.1785C>G
- NM_001408460.1:c.1785C>G
- NM_001408461.1:c.1785C>G
- NM_001408462.1:c.1785C>G
- NM_001408463.1:c.1785C>G
- NM_001408464.1:c.1785C>G
- NM_001408465.1:c.1785C>G
- NM_001408466.1:c.1785C>G
- NM_001408467.1:c.1785C>G
- NM_001408468.1:c.1782C>G
- NM_001408469.1:c.1782C>G
- NM_001408470.1:c.1782C>G
- NM_001408472.1:c.1926C>G
- NM_001408473.1:c.1923C>G
- NM_001408474.1:c.1728C>G
- NM_001408475.1:c.1725C>G
- NM_001408476.1:c.1725C>G
- NM_001408478.1:c.1719C>G
- NM_001408479.1:c.1719C>G
- NM_001408480.1:c.1719C>G
- NM_001408481.1:c.1716C>G
- NM_001408482.1:c.1716C>G
- NM_001408483.1:c.1716C>G
- NM_001408484.1:c.1716C>G
- NM_001408485.1:c.1716C>G
- NM_001408489.1:c.1716C>G
- NM_001408490.1:c.1716C>G
- NM_001408491.1:c.1716C>G
- NM_001408492.1:c.1713C>G
- NM_001408493.1:c.1713C>G
- NM_001408494.1:c.1689C>G
- NM_001408495.1:c.1683C>G
- NM_001408496.1:c.1665C>G
- NM_001408497.1:c.1665C>G
- NM_001408498.1:c.1665C>G
- NM_001408499.1:c.1665C>G
- NM_001408500.1:c.1665C>G
- NM_001408501.1:c.1665C>G
- NM_001408502.1:c.1662C>G
- NM_001408503.1:c.1662C>G
- NM_001408504.1:c.1662C>G
- NM_001408505.1:c.1659C>G
- NM_001408506.1:c.1602C>G
- NM_001408507.1:c.1599C>G
- NM_001408508.1:c.1590C>G
- NM_001408509.1:c.1587C>G
- NM_001408510.1:c.1548C>G
- NM_001408511.1:c.1545C>G
- NM_001408512.1:c.1425C>G
- NM_001408513.1:c.1398C>G
- NM_001408514.1:c.1002C>G
- NM_007294.4:c.5238C>GMANE SELECT
- NM_007297.4:c.5097C>G
- NM_007298.4:c.1926C>G
- NM_007299.4:c.1926C>G
- NM_007300.4:c.5301C>G
- NM_007304.2:c.1926C>G
- NP_001394500.1:p.His1675Gln
- NP_001394510.1:p.His1768Gln
- NP_001394511.1:p.His1768Gln
- NP_001394512.1:p.His1767Gln
- NP_001394514.1:p.His1767Gln
- NP_001394516.1:p.His1767Gln
- NP_001394519.1:p.His1766Gln
- NP_001394520.1:p.His1766Gln
- NP_001394522.1:p.His1746Gln
- NP_001394523.1:p.His1746Gln
- NP_001394525.1:p.His1746Gln
- NP_001394526.1:p.His1746Gln
- NP_001394527.1:p.His1746Gln
- NP_001394531.1:p.His1746Gln
- NP_001394532.1:p.His1746Gln
- NP_001394534.1:p.His1746Gln
- NP_001394539.1:p.His1745Gln
- NP_001394540.1:p.His1745Gln
- NP_001394541.1:p.His1745Gln
- NP_001394542.1:p.His1745Gln
- NP_001394543.1:p.His1745Gln
- NP_001394544.1:p.His1745Gln
- NP_001394545.1:p.His1745Gln
- NP_001394546.1:p.His1745Gln
- NP_001394547.1:p.His1745Gln
- NP_001394548.1:p.His1745Gln
- NP_001394549.1:p.His1745Gln
- NP_001394550.1:p.His1745Gln
- NP_001394551.1:p.His1745Gln
- NP_001394552.1:p.His1745Gln
- NP_001394553.1:p.His1745Gln
- NP_001394554.1:p.His1745Gln
- NP_001394555.1:p.His1745Gln
- NP_001394556.1:p.His1744Gln
- NP_001394557.1:p.His1744Gln
- NP_001394558.1:p.His1744Gln
- NP_001394559.1:p.His1744Gln
- NP_001394560.1:p.His1744Gln
- NP_001394561.1:p.His1744Gln
- NP_001394562.1:p.His1744Gln
- NP_001394563.1:p.His1744Gln
- NP_001394564.1:p.His1744Gln
- NP_001394565.1:p.His1744Gln
- NP_001394566.1:p.His1744Gln
- NP_001394567.1:p.His1744Gln
- NP_001394568.1:p.His1744Gln
- NP_001394569.1:p.His1744Gln
- NP_001394570.1:p.His1744Gln
- NP_001394571.1:p.His1744Gln
- NP_001394573.1:p.His1743Gln
- NP_001394574.1:p.His1743Gln
- NP_001394575.1:p.His1742Gln
- NP_001394576.1:p.His1741Gln
- NP_001394577.1:p.His1727Gln
- NP_001394578.1:p.His1726Gln
- NP_001394581.1:p.His1720Gln
- NP_001394582.1:p.His1720Gln
- NP_001394583.1:p.His1720Gln
- NP_001394584.1:p.His1720Gln
- NP_001394585.1:p.His1719Gln
- NP_001394586.1:p.His1719Gln
- NP_001394587.1:p.His1719Gln
- NP_001394588.1:p.His1718Gln
- NP_001394589.1:p.His1718Gln
- NP_001394590.1:p.His1718Gln
- NP_001394591.1:p.His1718Gln
- NP_001394592.1:p.His1718Gln
- NP_001394593.1:p.His1705Gln
- NP_001394594.1:p.His1705Gln
- NP_001394595.1:p.His1705Gln
- NP_001394596.1:p.His1705Gln
- NP_001394597.1:p.His1705Gln
- NP_001394598.1:p.His1705Gln
- NP_001394599.1:p.His1704Gln
- NP_001394600.1:p.His1704Gln
- NP_001394601.1:p.His1704Gln
- NP_001394602.1:p.His1704Gln
- NP_001394603.1:p.His1704Gln
- NP_001394604.1:p.His1704Gln
- NP_001394605.1:p.His1704Gln
- NP_001394606.1:p.His1704Gln
- NP_001394607.1:p.His1704Gln
- NP_001394608.1:p.His1704Gln
- NP_001394609.1:p.His1704Gln
- NP_001394610.1:p.His1703Gln
- NP_001394611.1:p.His1703Gln
- NP_001394612.1:p.His1703Gln
- NP_001394613.1:p.His1746Gln
- NP_001394614.1:p.His1703Gln
- NP_001394615.1:p.His1703Gln
- NP_001394616.1:p.His1703Gln
- NP_001394617.1:p.His1703Gln
- NP_001394618.1:p.His1703Gln
- NP_001394619.1:p.His1702Gln
- NP_001394620.1:p.His1702Gln
- NP_001394621.1:p.His1699Gln
- NP_001394623.1:p.His1699Gln
- NP_001394624.1:p.His1699Gln
- NP_001394625.1:p.His1699Gln
- NP_001394626.1:p.His1699Gln
- NP_001394627.1:p.His1699Gln
- NP_001394653.1:p.His1699Gln
- NP_001394654.1:p.His1699Gln
- NP_001394655.1:p.His1699Gln
- NP_001394656.1:p.His1699Gln
- NP_001394657.1:p.His1699Gln
- NP_001394658.1:p.His1699Gln
- NP_001394659.1:p.His1699Gln
- NP_001394660.1:p.His1699Gln
- NP_001394661.1:p.His1698Gln
- NP_001394662.1:p.His1698Gln
- NP_001394663.1:p.His1698Gln
- NP_001394664.1:p.His1698Gln
- NP_001394665.1:p.His1698Gln
- NP_001394666.1:p.His1698Gln
- NP_001394667.1:p.His1698Gln
- NP_001394668.1:p.His1698Gln
- NP_001394669.1:p.His1698Gln
- NP_001394670.1:p.His1698Gln
- NP_001394671.1:p.His1698Gln
- NP_001394672.1:p.His1698Gln
- NP_001394673.1:p.His1698Gln
- NP_001394674.1:p.His1698Gln
- NP_001394675.1:p.His1698Gln
- NP_001394676.1:p.His1698Gln
- NP_001394677.1:p.His1698Gln
- NP_001394678.1:p.His1698Gln
- NP_001394679.1:p.His1698Gln
- NP_001394680.1:p.His1698Gln
- NP_001394681.1:p.His1698Gln
- NP_001394767.1:p.His1697Gln
- NP_001394768.1:p.His1697Gln
- NP_001394770.1:p.His1697Gln
- NP_001394771.1:p.His1697Gln
- NP_001394772.1:p.His1697Gln
- NP_001394773.1:p.His1697Gln
- NP_001394774.1:p.His1697Gln
- NP_001394775.1:p.His1697Gln
- NP_001394776.1:p.His1697Gln
- NP_001394777.1:p.His1697Gln
- NP_001394778.1:p.His1697Gln
- NP_001394779.1:p.His1697Gln
- NP_001394780.1:p.His1697Gln
- NP_001394781.1:p.His1697Gln
- NP_001394782.1:p.His1697Gln
- NP_001394783.1:p.His1746Gln
- NP_001394787.1:p.His1745Gln
- NP_001394788.1:p.His1745Gln
- NP_001394789.1:p.His1745Gln
- NP_001394790.1:p.His1744Gln
- NP_001394791.1:p.His1679Gln
- NP_001394792.1:p.His1678Gln
- NP_001394803.1:p.His1677Gln
- NP_001394804.1:p.His1677Gln
- NP_001394808.1:p.His1676Gln
- NP_001394810.1:p.His1676Gln
- NP_001394811.1:p.His1676Gln
- NP_001394813.1:p.His1676Gln
- NP_001394814.1:p.His1676Gln
- NP_001394815.1:p.His1676Gln
- NP_001394816.1:p.His1676Gln
- NP_001394818.1:p.His1676Gln
- NP_001394823.1:p.His1675Gln
- NP_001394824.1:p.His1675Gln
- NP_001394825.1:p.His1675Gln
- NP_001394826.1:p.His1675Gln
- NP_001394827.1:p.His1675Gln
- NP_001394828.1:p.His1675Gln
- NP_001394829.1:p.His1675Gln
- NP_001394831.1:p.His1675Gln
- NP_001394833.1:p.His1675Gln
- NP_001394835.1:p.His1675Gln
- NP_001394836.1:p.His1675Gln
- NP_001394837.1:p.His1675Gln
- NP_001394838.1:p.His1675Gln
- NP_001394839.1:p.His1675Gln
- NP_001394844.1:p.His1674Gln
- NP_001394845.1:p.His1674Gln
- NP_001394846.1:p.His1674Gln
- NP_001394847.1:p.His1674Gln
- NP_001394848.1:p.His1705Gln
- NP_001394849.1:p.His1658Gln
- NP_001394850.1:p.His1658Gln
- NP_001394851.1:p.His1658Gln
- NP_001394852.1:p.His1658Gln
- NP_001394853.1:p.His1658Gln
- NP_001394854.1:p.His1658Gln
- NP_001394855.1:p.His1658Gln
- NP_001394856.1:p.His1657Gln
- NP_001394857.1:p.His1657Gln
- NP_001394858.1:p.His1657Gln
- NP_001394859.1:p.His1657Gln
- NP_001394860.1:p.His1657Gln
- NP_001394861.1:p.His1657Gln
- NP_001394862.1:p.His1657Gln
- NP_001394863.1:p.His1656Gln
- NP_001394864.1:p.His1656Gln
- NP_001394865.1:p.His1656Gln
- NP_001394866.1:p.His1705Gln
- NP_001394867.1:p.His1705Gln
- NP_001394868.1:p.His1704Gln
- NP_001394869.1:p.His1704Gln
- NP_001394870.1:p.His1703Gln
- NP_001394871.1:p.His1699Gln
- NP_001394872.1:p.His1698Gln
- NP_001394873.1:p.His1698Gln
- NP_001394874.1:p.His1698Gln
- NP_001394875.1:p.His1635Gln
- NP_001394876.1:p.His1635Gln
- NP_001394877.1:p.His1635Gln
- NP_001394878.1:p.His1635Gln
- NP_001394879.1:p.His1634Gln
- NP_001394880.1:p.His1634Gln
- NP_001394881.1:p.His1634Gln
- NP_001394882.1:p.His1634Gln
- NP_001394883.1:p.His1634Gln
- NP_001394884.1:p.His1634Gln
- NP_001394885.1:p.His1633Gln
- NP_001394886.1:p.His1633Gln
- NP_001394887.1:p.His1633Gln
- NP_001394888.1:p.His1619Gln
- NP_001394889.1:p.His1618Gln
- NP_001394891.1:p.His1618Gln
- NP_001394892.1:p.His1617Gln
- NP_001394893.1:p.His1592Gln
- NP_001394894.1:p.His1577Gln
- NP_001394895.1:p.His1450Gln
- NP_001394896.1:p.His1449Gln
- NP_001394897.1:p.His878Gln
- NP_001394898.1:p.His877Gln
- NP_001394899.1:p.His665Gln
- NP_001394900.1:p.His665Gln
- NP_001394901.1:p.His664Gln
- NP_001394902.1:p.His643Gln
- NP_001394903.1:p.His643Gln
- NP_001394904.1:p.His643Gln
- NP_001394905.1:p.His643Gln
- NP_001394906.1:p.His643Gln
- NP_001394907.1:p.His643Gln
- NP_001394908.1:p.His642Gln
- NP_001394909.1:p.His642Gln
- NP_001394910.1:p.His642Gln
- NP_001394911.1:p.His642Gln
- NP_001394912.1:p.His642Gln
- NP_001394913.1:p.His642Gln
- NP_001394914.1:p.His642Gln
- NP_001394915.1:p.His642Gln
- NP_001394919.1:p.His642Gln
- NP_001394920.1:p.His642Gln
- NP_001394921.1:p.His642Gln
- NP_001394922.1:p.His642Gln
- NP_001395321.1:p.His641Gln
- NP_001395325.1:p.His641Gln
- NP_001395326.1:p.His641Gln
- NP_001395327.1:p.His641Gln
- NP_001395328.1:p.His641Gln
- NP_001395329.1:p.His641Gln
- NP_001395330.1:p.His641Gln
- NP_001395331.1:p.His641Gln
- NP_001395332.1:p.His641Gln
- NP_001395333.1:p.His641Gln
- NP_001395335.1:p.His640Gln
- NP_001395336.1:p.His640Gln
- NP_001395337.1:p.His640Gln
- NP_001395338.1:p.His639Gln
- NP_001395339.1:p.His618Gln
- NP_001395340.1:p.His617Gln
- NP_001395341.1:p.His616Gln
- NP_001395342.1:p.His616Gln
- NP_001395343.1:p.His616Gln
- NP_001395344.1:p.His616Gln
- NP_001395345.1:p.His616Gln
- NP_001395347.1:p.His604Gln
- NP_001395348.1:p.His604Gln
- NP_001395349.1:p.His604Gln
- NP_001395350.1:p.His603Gln
- NP_001395351.1:p.His603Gln
- NP_001395352.1:p.His603Gln
- NP_001395353.1:p.His603Gln
- NP_001395354.1:p.His602Gln
- NP_001395355.1:p.His602Gln
- NP_001395356.1:p.His602Gln
- NP_001395357.1:p.His602Gln
- NP_001395358.1:p.His602Gln
- NP_001395359.1:p.His602Gln
- NP_001395360.1:p.His602Gln
- NP_001395361.1:p.His601Gln
- NP_001395362.1:p.His601Gln
- NP_001395363.1:p.His601Gln
- NP_001395364.1:p.His601Gln
- NP_001395365.1:p.His601Gln
- NP_001395366.1:p.His601Gln
- NP_001395367.1:p.His601Gln
- NP_001395368.1:p.His601Gln
- NP_001395369.1:p.His601Gln
- NP_001395370.1:p.His601Gln
- NP_001395371.1:p.His601Gln
- NP_001395372.1:p.His601Gln
- NP_001395373.1:p.His601Gln
- NP_001395374.1:p.His600Gln
- NP_001395375.1:p.His600Gln
- NP_001395376.1:p.His600Gln
- NP_001395377.1:p.His600Gln
- NP_001395379.1:p.His600Gln
- NP_001395380.1:p.His598Gln
- NP_001395381.1:p.His596Gln
- NP_001395382.1:p.His596Gln
- NP_001395383.1:p.His596Gln
- NP_001395384.1:p.His596Gln
- NP_001395385.1:p.His596Gln
- NP_001395386.1:p.His596Gln
- NP_001395387.1:p.His595Gln
- NP_001395388.1:p.His595Gln
- NP_001395389.1:p.His595Gln
- NP_001395390.1:p.His595Gln
- NP_001395391.1:p.His595Gln
- NP_001395392.1:p.His595Gln
- NP_001395393.1:p.His595Gln
- NP_001395394.1:p.His595Gln
- NP_001395395.1:p.His595Gln
- NP_001395396.1:p.His595Gln
- NP_001395397.1:p.His594Gln
- NP_001395398.1:p.His594Gln
- NP_001395399.1:p.His594Gln
- NP_001395401.1:p.His642Gln
- NP_001395402.1:p.His641Gln
- NP_001395403.1:p.His576Gln
- NP_001395404.1:p.His575Gln
- NP_001395405.1:p.His575Gln
- NP_001395407.1:p.His573Gln
- NP_001395408.1:p.His573Gln
- NP_001395409.1:p.His573Gln
- NP_001395410.1:p.His572Gln
- NP_001395411.1:p.His572Gln
- NP_001395412.1:p.His572Gln
- NP_001395413.1:p.His572Gln
- NP_001395414.1:p.His572Gln
- NP_001395418.1:p.His572Gln
- NP_001395419.1:p.His572Gln
- NP_001395420.1:p.His572Gln
- NP_001395421.1:p.His571Gln
- NP_001395422.1:p.His571Gln
- NP_001395423.1:p.His563Gln
- NP_001395424.1:p.His561Gln
- NP_001395425.1:p.His555Gln
- NP_001395426.1:p.His555Gln
- NP_001395427.1:p.His555Gln
- NP_001395428.1:p.His555Gln
- NP_001395429.1:p.His555Gln
- NP_001395430.1:p.His555Gln
- NP_001395431.1:p.His554Gln
- NP_001395432.1:p.His554Gln
- NP_001395433.1:p.His554Gln
- NP_001395434.1:p.His553Gln
- NP_001395435.1:p.His534Gln
- NP_001395436.1:p.His533Gln
- NP_001395437.1:p.His530Gln
- NP_001395438.1:p.His529Gln
- NP_001395439.1:p.His516Gln
- NP_001395440.1:p.His515Gln
- NP_001395441.1:p.His475Gln
- NP_001395442.1:p.His466Gln
- NP_001395443.1:p.His334Gln
- NP_009225.1:p.His1746Gln
- NP_009225.1:p.His1746Gln
- NP_009228.2:p.His1699Gln
- NP_009229.2:p.His642Gln
- NP_009229.2:p.His642Gln
- NP_009230.2:p.His642Gln
- NP_009231.2:p.His1767Gln
- NP_009235.2:p.His642Gln
- LRG_292t1:c.5238C>G
- LRG_292:g.160893C>G
- LRG_292p1:p.His1746Gln
- NC_000017.10:g.41209108G>C
- NM_007294.3:c.5238C>G
- NM_007298.3:c.1926C>G
- NR_027676.2:n.5415C>G
- P38398:p.His1746Gln
- p.H1746Q
This HGVS expression did not pass validation- Protein change:
- H1449Q
- Links:
- UniProtKB: P38398#VAR_070509; dbSNP: rs786202389
- NCBI 1000 Genomes Browser:
- rs786202389
- Molecular consequence:
- NM_001407571.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407581.1:c.5304C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407582.1:c.5304C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407583.1:c.5301C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407585.1:c.5301C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407587.1:c.5301C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407590.1:c.5298C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407591.1:c.5298C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407593.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407594.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407596.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407597.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407598.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407602.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407603.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407605.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407610.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407611.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407612.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407613.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407614.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407615.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407616.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407617.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407618.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407619.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407620.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407621.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407622.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407623.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407624.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407625.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407626.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407627.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407628.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407629.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407630.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407631.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407632.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407633.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407634.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407635.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407636.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407637.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407638.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407639.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407640.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407641.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407642.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407644.1:c.5229C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407645.1:c.5229C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407646.1:c.5226C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407647.1:c.5223C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407648.1:c.5181C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407649.1:c.5178C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407652.1:c.5160C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407653.1:c.5160C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407654.1:c.5160C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407655.1:c.5160C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407656.1:c.5157C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407657.1:c.5157C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407658.1:c.5157C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407659.1:c.5154C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407660.1:c.5154C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407661.1:c.5154C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407662.1:c.5154C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407663.1:c.5154C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407664.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407665.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407666.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407667.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407668.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407669.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407670.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407671.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407672.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407673.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407674.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407675.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407676.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407677.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407678.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407679.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407680.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407681.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407682.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407683.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407684.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407685.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407686.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407687.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407688.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407689.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407690.1:c.5106C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407691.1:c.5106C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407692.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407694.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407695.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407696.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407697.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407698.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407724.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407725.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407726.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407727.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407728.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407729.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407730.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407731.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407732.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407733.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407734.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407735.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407736.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407737.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407738.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407739.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407740.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407741.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407742.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407743.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407744.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407745.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407746.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407747.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407748.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407749.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407750.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407751.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407752.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407838.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407839.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407841.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407842.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407843.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407844.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407845.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407846.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407847.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407848.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407849.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407850.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407851.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407852.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407853.1:c.5091C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407854.1:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407858.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407859.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407860.1:c.5235C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407861.1:c.5232C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407862.1:c.5037C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407863.1:c.5034C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407874.1:c.5031C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407875.1:c.5031C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407879.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407881.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407882.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407884.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407885.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407886.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407887.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407889.1:c.5028C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407894.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407895.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407896.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407897.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407898.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407899.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407900.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407902.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407904.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407906.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407907.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407908.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407909.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407910.1:c.5025C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407915.1:c.5022C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407916.1:c.5022C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407917.1:c.5022C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407918.1:c.5022C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407919.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407920.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407921.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407922.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407923.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407924.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407925.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407926.1:c.4974C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407927.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407928.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407929.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407930.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407931.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407932.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407933.1:c.4971C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407934.1:c.4968C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407935.1:c.4968C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407936.1:c.4968C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407937.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407938.1:c.5115C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407939.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407940.1:c.5112C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407941.1:c.5109C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407942.1:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407943.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407944.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407945.1:c.5094C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407946.1:c.4905C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407947.1:c.4905C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407948.1:c.4905C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407949.1:c.4905C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407950.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407951.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407952.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407953.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407954.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407955.1:c.4902C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407956.1:c.4899C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407957.1:c.4899C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407958.1:c.4899C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407959.1:c.4857C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407960.1:c.4854C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407962.1:c.4854C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407963.1:c.4851C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407964.1:c.4776C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407965.1:c.4731C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407966.1:c.4350C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407967.1:c.4347C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407968.1:c.2634C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407969.1:c.2631C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407970.1:c.1995C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407971.1:c.1995C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407972.1:c.1992C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407973.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407974.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407975.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407976.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407977.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407978.1:c.1929C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407979.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407980.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407981.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407982.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407983.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407984.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407985.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407986.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407990.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407991.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407992.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001407993.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408392.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408396.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408397.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408398.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408399.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408400.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408401.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408402.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408403.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408404.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408406.1:c.1920C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408407.1:c.1920C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408408.1:c.1920C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408409.1:c.1917C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408410.1:c.1854C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408411.1:c.1851C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408412.1:c.1848C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408413.1:c.1848C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408414.1:c.1848C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408415.1:c.1848C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408416.1:c.1848C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408418.1:c.1812C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408419.1:c.1812C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408420.1:c.1812C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408421.1:c.1809C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408422.1:c.1809C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408423.1:c.1809C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408424.1:c.1809C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408425.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408426.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408427.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408428.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408429.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408430.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408431.1:c.1806C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408432.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408433.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408434.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408435.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408436.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408437.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408438.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408439.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408440.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408441.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408442.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408443.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408444.1:c.1803C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408445.1:c.1800C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408446.1:c.1800C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408447.1:c.1800C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408448.1:c.1800C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408450.1:c.1800C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408451.1:c.1794C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408452.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408453.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408454.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408455.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408456.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408457.1:c.1788C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408458.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408459.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408460.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408461.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408462.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408463.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408464.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408465.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408466.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408467.1:c.1785C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408468.1:c.1782C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408469.1:c.1782C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408470.1:c.1782C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408472.1:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408473.1:c.1923C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408474.1:c.1728C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408475.1:c.1725C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408476.1:c.1725C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408478.1:c.1719C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408479.1:c.1719C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408480.1:c.1719C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408481.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408482.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408483.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408484.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408485.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408489.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408490.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408491.1:c.1716C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408492.1:c.1713C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408493.1:c.1713C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408494.1:c.1689C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408495.1:c.1683C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408496.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408497.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408498.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408499.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408500.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408501.1:c.1665C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408502.1:c.1662C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408503.1:c.1662C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408504.1:c.1662C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408505.1:c.1659C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408506.1:c.1602C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408507.1:c.1599C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408508.1:c.1590C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408509.1:c.1587C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408510.1:c.1548C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408511.1:c.1545C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408512.1:c.1425C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408513.1:c.1398C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_001408514.1:c.1002C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007294.4:c.5238C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007297.4:c.5097C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007298.4:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007299.4:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007300.4:c.5301C>G - missense variant - [Sequence Ontology: SO:0001583]
- NM_007304.2:c.1926C>G - missense variant - [Sequence Ontology: SO:0001583]
- NR_027676.2:n.5415C>G - non-coding transcript variant - [Sequence Ontology: SO:0001619]
- Functional consequence:
- function_uncertain_variant [Sequence Ontology: SO:0002220] - Comment(s)
- The saturation genome editing (SGE) assay for BRCA1 NM_007294.3:c.5238C>G, a MISSENSE variant, produced a function score of -0.9, corresponding to a functional classification of INTERMEDIATE. SGE function score ranges for classification are as follows: ‘functional’, score > -0.748; ‘intermediate’, -0.748 > score > -1.328; ‘non-functional’, score < -1.328. The median synonymous SNV scored 0.0 and the median nonsense SNV scored -2.12.
Condition(s)
- Name:
- Hereditary breast ovarian cancer syndrome
- Synonyms:
- Hereditary breast and ovarian cancer syndrome; Hereditary breast and ovarian cancer; Hereditary breast and ovarian cancer syndrome (HBOC); See all synonyms [MedGen]
- Identifiers:
- MONDO: MONDO:0003582; MeSH: D061325; MedGen: C0677776; Orphanet: 145
-
SRX24495910 (1)
SRA
-
Licensure
LicensureThe legal authority or formal permission from authorities to carry on certain activities which by law or regulation require such permission. It may be applied to licensure of ...<br/>MeSH
Your browsing activity is empty.
Activity recording is turned off.
See more...Assertion and evidence details
Submission Accession | Submitter | Review Status (Assertion method) | Clinical Significance (Last evaluated) | Origin | Method | Citations |
---|---|---|---|---|---|---|
SCV003258287 | Labcorp Genetics (formerly Invitae), Labcorp | criteria provided, single submitter (Invitae Variant Classification Sherloc (09022015)) | Uncertain significance (Sep 12, 2023) | germline | clinical testing |
Summary from all submissions
Ethnicity | Origin | Affected | Individuals | Families | Chromosomes tested | Number Tested | Family history | Method |
---|---|---|---|---|---|---|---|---|
not provided | germline | unknown | not provided | not provided | not provided | not provided | not provided | clinical testing |
Citations
PubMed
A high-throughput functional complementation assay for classification of BRCA1 missense variants.
Bouwman P, van der Gulden H, van der Heijden I, Drost R, Klijn CN, Prasetyanti P, Pieterse M, Wientjens E, Seibler J, Hogervorst FB, Jonkers J.
Cancer Discov. 2013 Oct;3(10):1142-55. doi: 10.1158/2159-8290.CD-13-0094. Epub 2013 Jul 18.
- PMID:
- 23867111
Accurate classification of BRCA1 variants with saturation genome editing.
Findlay GM, Daza RM, Martin B, Zhang MD, Leith AP, Gasperini M, Janizek JD, Huang X, Starita LM, Shendure J.
Nature. 2018 Oct;562(7726):217-222. doi: 10.1038/s41586-018-0461-z. Epub 2018 Sep 12.
- PMID:
- 30209399
- PMCID:
- PMC6181777
Details of each submission
From Labcorp Genetics (formerly Invitae), Labcorp, SCV003258287.2
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | PubMed (4) |
Description
This sequence change replaces histidine, which is basic and polar, with glutamine, which is neutral and polar, at codon 1746 of the BRCA1 protein (p.His1746Gln). This variant is not present in population databases (gnomAD no frequency). This variant has not been reported in the literature in individuals affected with BRCA1-related conditions. ClinVar contains an entry for this variant (Variation ID: 185702). Experimental studies are conflicting or provide insufficient evidence to determine the effect of this variant on BRCA1 function (PMID: 23867111, 30209399, 32546644). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is not expected to disrupt BRCA1 protein function. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance.
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | unknown | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
Last Updated: Oct 8, 2024