U.S. flag

An official website of the United States government

NM_004333.6(BRAF):c.1432+120A>T AND Prostate cancer, hereditary, 1

Germline classification:
Uncertain significance (1 submission)
Last evaluated:
Jul 29, 2022
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV002293318.2

Allele description [Variation Report for NM_004333.6(BRAF):c.1432+120A>T]

NM_004333.6(BRAF):c.1432+120A>T

Gene:
BRAF:B-Raf proto-oncogene, serine/threonine kinase [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
7q34
Genomic location:
Preferred name:
NM_004333.6(BRAF):c.1432+120A>T
HGVS:
  • NC_000007.14:g.140781456T>A
  • NG_007873.3:g.148309A>T
  • NM_001354609.2:c.1432+120A>T
  • NM_001374244.1:c.1552+120A>T
  • NM_001374258.1:c.1552+120A>T
  • NM_001378467.1:c.1441+120A>T
  • NM_001378468.1:c.1432+120A>T
  • NM_001378469.1:c.1366+120A>T
  • NM_001378470.1:c.1330+120A>T
  • NM_001378471.1:c.1321+120A>T
  • NM_001378472.1:c.1276+120A>T
  • NM_001378473.1:c.1276+120A>T
  • NM_001378474.1:c.1432+120A>T
  • NM_001378475.1:c.1168+120A>T
  • NM_004333.6:c.1432+120A>TMANE SELECT
  • LRG_299:g.148309A>T
  • NC_000007.13:g.140481256T>A
Molecular consequence:
  • NM_001354609.2:c.1432+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001374244.1:c.1552+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001374258.1:c.1552+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378467.1:c.1441+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378468.1:c.1432+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378469.1:c.1366+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378470.1:c.1330+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378471.1:c.1321+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378472.1:c.1276+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378473.1:c.1276+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378474.1:c.1432+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001378475.1:c.1168+120A>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_004333.6:c.1432+120A>T - intron variant - [Sequence Ontology: SO:0001627]

Condition(s)

Name:
Prostate cancer, hereditary, 1 (HPC1)
Identifiers:
MONDO: MONDO:0011098; MedGen: C4722327; Orphanet: 1331; OMIM: 601518

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

Assertion and evidence details

Help
Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV002586309Laboratory of Virology, Oncology, Biosciences and Environment, Faculty of Sciences and Techniques, Mohammedia- University Hassan II of Casablanca
no assertion criteria provided
Uncertain significance
(Jul 29, 2022) 		germlineclinical testing

Help

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
Moroccangermlineyesnot providednot providednot providednot providednot providedclinical testing

Details of each submission

From Laboratory of Virology, Oncology, Biosciences and Environment, Faculty of Sciences and Techniques, Mohammedia- University Hassan II of Casablanca, SCV002586309.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1Moroccannot providednot providednot providedclinical testingnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineyesnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Nov 5, 2022