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NM_000492.4(CFTR):c.1651G>A (p.Gly551Ser) AND Hereditary pancreatitis

Germline classification:
Pathogenic (1 submission)
Last evaluated:
May 4, 2022
Review status:
1 star out of maximum of 4 stars
criteria provided, single submitter
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV002247261.1

Allele description [Variation Report for NM_000492.4(CFTR):c.1651G>A (p.Gly551Ser)]

NM_000492.4(CFTR):c.1651G>A (p.Gly551Ser)

Genes:
CFTR:CF transmembrane conductance regulator [Gene - OMIM - HGNC]
LOC111674475:CFTR intron 11 enhancer [Gene]
Variant type:
single nucleotide variant
Cytogenetic location:
7q31.2
Genomic location:
Preferred name:
NM_000492.4(CFTR):c.1651G>A (p.Gly551Ser)
HGVS:
  • NC_000007.14:g.117587805G>A
  • NG_016465.4:g.127022G>A
  • NG_056131.3:g.760G>A
  • NM_000492.4:c.1651G>AMANE SELECT
  • NP_000483.3:p.Gly551Ser
  • NP_000483.3:p.Gly551Ser
  • LRG_663t1:c.1651G>A
  • LRG_663:g.127022G>A
  • LRG_663p1:p.Gly551Ser
  • NC_000007.13:g.117227859G>A
  • NG_056131.1:g.129G>A
  • NM_000492.3:c.1651G>A
  • P13569:p.Gly551Ser
Protein change:
G551S; GLY551SER
Links:
PharmGKB: 1183960780; PharmGKB: 1183960780PA165950341; PharmGKB Clinical Annotation: 1183960780; UniProtKB: P13569#VAR_000180; OMIM: 602421.0037; dbSNP: rs121909013
NCBI 1000 Genomes Browser:
rs121909013
Molecular consequence:
  • NM_000492.4:c.1651G>A - missense variant - [Sequence Ontology: SO:0001583]

Condition(s)

Name:
Hereditary pancreatitis (PCTT)
Synonyms:
Hereditary chronic pancreatitis
Identifiers:
MONDO: MONDO:0008185; MedGen: C0238339; Orphanet: 676; OMIM: 167800

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Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV002518679Mendelics
criteria provided, single submitter

(Mendelics Assertion Criteria 2019)
Pathogenic
(May 4, 2022)
germlineclinical testing

Citation Link

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineunknownnot providednot providednot providednot providednot providedclinical testing

Details of each submission

From Mendelics, SCV002518679.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedclinical testingnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineunknownnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Sep 29, 2024