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NM_000492.4(CFTR):c.1762G>A (p.Glu588Lys) AND not specified

Germline classification:
Uncertain significance (1 submission)
Last evaluated:
Dec 11, 2023
Review status:
1 star out of maximum of 4 stars
criteria provided, single submitter
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV001201269.2

Allele description [Variation Report for NM_000492.4(CFTR):c.1762G>A (p.Glu588Lys)]

NM_000492.4(CFTR):c.1762G>A (p.Glu588Lys)

Gene:
CFTR:CF transmembrane conductance regulator [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
7q31.2
Genomic location:
Preferred name:
NM_000492.4(CFTR):c.1762G>A (p.Glu588Lys)
HGVS:
  • NC_000007.14:g.117590435G>A
  • NG_016465.4:g.129652G>A
  • NM_000492.4:c.1762G>AMANE SELECT
  • NP_000483.3:p.Glu588Lys
  • LRG_663t1:c.1762G>A
  • LRG_663:g.129652G>A
  • NC_000007.13:g.117230489G>A
  • NM_000492.3:c.1762G>A
Protein change:
E588K
Links:
dbSNP: rs755986694
NCBI 1000 Genomes Browser:
rs755986694
Molecular consequence:
  • NM_000492.4:c.1762G>A - missense variant - [Sequence Ontology: SO:0001583]

Condition(s)

Synonyms:
AllHighlyPenetrant
Identifiers:
MedGen: CN169374

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Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV001372380Women's Health and Genetics/Laboratory Corporation of America, LabCorp
criteria provided, single submitter

(LabCorp Variant Classification Summary - May 2015)
Uncertain significance
(Dec 11, 2023)
germlineclinical testing

PubMed (1)
[See all records that cite this PMID]

Citation Link

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineunknownnot providednot providednot providednot providednot providedclinical testing

Citations

PubMed

The true panel of cystic fibrosis mutations in the Sicilian population.

Chamayou S, Sicali M, Lombardo D, Maglia E, Liprino A, Cardea C, Fichera M, Venti E, Guglielmino A.

BMC Med Genet. 2020 May 1;21(1):89. doi: 10.1186/s12881-020-0958-9.

PubMed [citation]
PMID:
32357917
PMCID:
PMC7195759

Details of each submission

From Women's Health and Genetics/Laboratory Corporation of America, LabCorp, SCV001372380.2

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedclinical testing PubMed (1)

Description

Variant summary: CFTR c.1762G>A (p.Glu588Lys) results in a conservative amino acid change located in the ABC transporter-like, ATP-binding domain (IPR003439) of the encoded protein sequence. Three of five in-silico tools predict a benign effect of the variant on protein function. The variant allele was found at a frequency of 2e-05 in 249442 control chromosomes (gnomAD). The available data on variant occurrences in the general population are insufficient to allow any conclusion about variant significance. c.1762G>A has been reported in the literature in at least one female tested for infertility (example, Chamayou_2019). This report does not provide unequivocal conclusions about association of the variant with Chronic Pancreatitis, Cystic Fibrosis or related disorders. To our knowledge, no experimental evidence demonstrating an impact on protein function has been reported. The following publication was ascertained in the context of this evaluation (PMID: 32357917). Three submitters have reported clinical-significance assessments for this variant to ClinVar after 2014. All submitters classified the variant as uncertain significance. Based on the evidence outlined above, the variant was classified as uncertain significance.

#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineunknownnot providednot providednot providednot providednot providednot providednot provided

Last Updated: May 19, 2024