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NM_000914.5(OPRM1):c.-35C>T AND Tramadol response

Germline classification:
drug response (1 submission)
Last evaluated:
Apr 28, 2018
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV001029191.2

Allele description [Variation Report for NM_000914.5(OPRM1):c.-35C>T]

NM_000914.5(OPRM1):c.-35C>T

Gene:
OPRM1:opioid receptor mu 1 [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
6q25.2
Genomic location:
Preferred name:
NM_000914.5(OPRM1):c.-35C>T
HGVS:
  • NC_000006.12:g.154039510C>T
  • NG_021208.2:g.34010C>T
  • NM_000914.5:c.-35C>TMANE SELECT
  • NM_001008503.3:c.-35C>T
  • NM_001008504.4:c.-35C>T
  • NM_001008505.2:c.-35C>T
  • NM_001145279.4:c.245C>T
  • NM_001145280.4:c.-11+28492C>T
  • NM_001145281.3:c.47+28951C>T
  • NM_001145282.2:c.-35C>T
  • NM_001145283.2:c.-35C>T
  • NM_001145284.3:c.-35C>T
  • NM_001145285.3:c.-35C>T
  • NM_001145286.3:c.-35C>T
  • NM_001285522.1:c.-35C>T
  • NM_001285523.3:c.-35C>T
  • NM_001285524.1:c.245C>T
  • NP_001138751.1:p.Thr82Ile
  • NP_001272453.1:p.Thr82Ile
  • LRG_1007t1:c.-35C>T
  • LRG_1007t2:c.-35C>T
  • LRG_1007:g.34010C>T
  • NC_000006.11:g.154360645C>T
  • NR_104348.1:n.100C>T
  • NR_104349.1:n.100C>T
  • NR_104350.1:n.100C>T
  • NR_104351.1:n.100C>T
Protein change:
T82I
Links:
dbSNP: rs370868117
NCBI 1000 Genomes Browser:
rs370868117
Molecular consequence:
  • NM_000914.5:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001008503.3:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001008504.4:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001008505.2:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145282.2:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145283.2:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145284.3:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145285.3:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145286.3:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001285522.1:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001285523.3:c.-35C>T - 5 prime UTR variant - [Sequence Ontology: SO:0001623]
  • NM_001145280.4:c.-11+28492C>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001145281.3:c.47+28951C>T - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001145279.4:c.245C>T - missense variant - [Sequence Ontology: SO:0001583]
  • NM_001285524.1:c.245C>T - missense variant - [Sequence Ontology: SO:0001583]
  • NR_104348.1:n.100C>T - non-coding transcript variant - [Sequence Ontology: SO:0001619]
  • NR_104349.1:n.100C>T - non-coding transcript variant - [Sequence Ontology: SO:0001619]
  • NR_104350.1:n.100C>T - non-coding transcript variant - [Sequence Ontology: SO:0001619]
  • NR_104351.1:n.100C>T - non-coding transcript variant - [Sequence Ontology: SO:0001619]

Condition(s)

Name:
Tramadol response
Synonyms:
Ultram response
Identifiers:
MedGen: CN078023

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Assertion and evidence details

Help
Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV001191977Bruce Budowle Laboratory, University of North Texas Health Science Center
no assertion criteria provided
drug response
(Apr 28, 2018)
Condition: Tramadol response		somaticresearch

Help

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedsomaticyes189not providednot providednot providednot providedresearch

Details of each submission

From Bruce Budowle Laboratory, University of North Texas Health Science Center, SCV001191977.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not provided189not providednot providedresearchnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1somaticyesnot providednot providednot provided189not providednot providednot provided

Last Updated: Apr 23, 2022