U.S. flag

An official website of the United States government

NM_000754.4(COMT):c.484-34del AND Tramadol response

Germline classification:
drug response (1 submission)
Last evaluated:
Apr 28, 2018
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV001028875.2

Allele description [Variation Report for NM_000754.4(COMT):c.484-34del]

NM_000754.4(COMT):c.484-34del

Gene:
COMT:catechol-O-methyltransferase [Gene - OMIM - HGNC]
Variant type:
Deletion
Cytogenetic location:
22q11.21
Genomic location:
Preferred name:
NM_000754.4(COMT):c.484-34del
HGVS:
  • NC_000022.11:g.19964134del
  • NG_011526.1:g.27395del
  • NM_000754.4:c.484-34delMANE SELECT
  • NM_001135161.2:c.484-34del
  • NM_001135162.2:c.484-34del
  • NM_001362828.2:c.484-34del
  • NM_007310.3:c.334-34del
  • LRG_1010:g.27395del
  • NC_000022.10:g.19951657del
Links:
dbSNP: rs1601530284
NCBI 1000 Genomes Browser:
rs1601530284
Molecular consequence:
  • NM_000754.4:c.484-34del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001135161.2:c.484-34del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001135162.2:c.484-34del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_001362828.2:c.484-34del - intron variant - [Sequence Ontology: SO:0001627]
  • NM_007310.3:c.334-34del - intron variant - [Sequence Ontology: SO:0001627]

Condition(s)

Name:
Tramadol response
Synonyms:
Ultram response
Identifiers:
MedGen: CN078023

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

Assertion and evidence details

Help
Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV001191661Bruce Budowle Laboratory, University of North Texas Health Science Center
no assertion criteria provided
drug response
(Apr 28, 2018)
Condition: Tramadol response		somaticresearch

Help

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedsomaticyes134not providednot providednot providednot providedresearch

Details of each submission

From Bruce Budowle Laboratory, University of North Texas Health Science Center, SCV001191661.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not provided134not providednot providedresearchnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1somaticyesnot providednot providednot provided134not providednot providednot provided

Last Updated: Apr 23, 2022