ClinVar

NM_004985.5(KRAS):c.470A>G (p.Tyr157Cys)

Gene:

KRAS:KRAS proto-oncogene, GTPase [Gene - OMIM - HGNC]

Variant type:

single nucleotide variant

Cytogenetic location:

12p12.1

Genomic location:

• Chr12: 25209892 (on Assembly GRCh38)
• Chr12: 25362826 (on Assembly GRCh37)

Preferred name:

NM_004985.5(KRAS):c.470A>G (p.Tyr157Cys)

HGVS:

• NC_000012.12:g.25209892T>C
• NG_007524.2:g.46112A>G
• NM_001369786.1:c.*24A>G
• NM_001369787.1:c.470A>G
• NM_004985.5:c.470A>GMANE SELECT
• NM_033360.4:c.*24A>G
• NP_001356716.1:p.Tyr157Cys
• NP_004976.2:p.Tyr157Cys
• LRG_344t1:c.470A>G
• LRG_344t2:c.*24A>G
• LRG_344:g.46112A>G
• LRG_344p1:p.Tyr157Cys
• NC_000012.11:g.25362826T>C
• NG_007524.1:g.46029A>G
• NM_004985.3:c.470A>G

This HGVS expression did not pass validation

Protein change:

Y157C

Links:

dbSNP: rs794727720

NCBI 1000 Genomes Browser:

rs794727720

Molecular consequence:

• NM_001369786.1:c.*24A>G - 3 prime UTR variant - [Sequence Ontology: SO:0001624]
• NM_033360.4:c.*24A>G - 3 prime UTR variant - [Sequence Ontology: SO:0001624]
• NM_001369787.1:c.470A>G - missense variant - [Sequence Ontology: SO:0001583]
• NM_004985.5:c.470A>G - missense variant - [Sequence Ontology: SO:0001583]

Observations:

1