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NM_058216.3(RAD51C):c.146-15T>C AND multiple conditions

Germline classification:
Likely benign (1 submission)
Last evaluated:
Apr 9, 2018
Review status:
1 star out of maximum of 4 stars
criteria provided, single submitter
Somatic classification
of clinical impact:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Somatic classification
of oncogenicity:
None
Review status:
(0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided
Record status:
current
Accession:
RCV000663171.1

Allele description [Variation Report for NM_058216.3(RAD51C):c.146-15T>C]

NM_058216.3(RAD51C):c.146-15T>C

Gene:
RAD51C:RAD51 paralog C [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
17q22
Genomic location:
Preferred name:
NM_058216.3(RAD51C):c.146-15T>C
HGVS:
  • NC_000017.11:g.58694916T>C
  • NG_023199.1:g.7315T>C
  • NG_047169.1:g.2164A>G
  • NM_002876.4:c.146-15T>C
  • NM_058216.3:c.146-15T>CMANE SELECT
  • LRG_314t1:c.146-15T>C
  • LRG_314:g.7315T>C
  • NC_000017.10:g.56772277T>C
  • NM_058216.1:c.146-15T>C
Links:
dbSNP: rs1036386535
NCBI 1000 Genomes Browser:
rs1036386535
Molecular consequence:
  • NM_002876.4:c.146-15T>C - intron variant - [Sequence Ontology: SO:0001627]
  • NM_058216.3:c.146-15T>C - intron variant - [Sequence Ontology: SO:0001627]

Condition(s)

Name:
Breast-ovarian cancer, familial, susceptibility to, 3
Synonyms:
RAD51C-Related Breast/Ovarian Cancer; Breast-ovarian cancer, familial 3
Identifiers:
MONDO: MONDO:0013253; MedGen: C3150659; Orphanet: 145; OMIM: 613399
Name:
Fanconi anemia complementation group O
Identifiers:
MONDO: MONDO:0013248; MedGen: C3150653; Orphanet: 84; OMIM: 613390

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Assertion and evidence details

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Submission AccessionSubmitterReview Status
(Assertion method)		Clinical Significance
(Last evaluated)		OriginMethodCitations
SCV000786332Counsyl
criteria provided, single submitter

(Counsyl Autosomal Dominant Disease Classification criteria (2015))		Likely benign
(Apr 9, 2018) 		unknownclinical testing

Counsyl_Autosomal_Dominant_Disease_Classification_criteria_(2015)_v1.pdf

Citation Link

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Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedunknownunknownnot providednot providednot providednot providednot providedclinical testing

Details of each submission

From Counsyl, SCV000786332.2

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedclinical testingnot provided
#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1unknownunknownnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Apr 23, 2022