NM_007294.4(BRCA1):c.5074+1G>A AND Breast-ovarian cancer, familial, susceptibility to, 1
- Germline classification:
- Pathogenic (11 submissions)
- Last evaluated:
- Aug 10, 2015
- Review status:
- 3 stars out of maximum of 4 starsreviewed by expert panel
- Somatic classification
of clinical impact: - None
- Review status:
- (0/4) 0 stars out of maximum of 4 starsno assertion criteria provided
- Somatic classification
of oncogenicity: - None
- Review status:
- (0/4) 0 stars out of maximum of 4 starsno assertion criteria provided
- Record status:
- current
- Accession:
- RCV000031210.25
Allele description [Variation Report for NM_007294.4(BRCA1):c.5074+1G>A]
NM_007294.4(BRCA1):c.5074+1G>A
- Gene:
- BRCA1:BRCA1 DNA repair associated [Gene - OMIM - HGNC]
- Variant type:
- single nucleotide variant
- Cytogenetic location:
- 17q21.31
- Genomic location:
- Preferred name:
- NM_007294.4(BRCA1):c.5074+1G>A
- HGVS:
- NC_000017.11:g.43067607C>T
- NG_005905.2:g.150377G>A
- NM_001407571.1:c.4861+1G>A
- NM_001407581.1:c.5140+1G>A
- NM_001407582.1:c.5140+1G>A
- NM_001407583.1:c.5137+1G>A
- NM_001407585.1:c.5137+1G>A
- NM_001407587.1:c.5137+1G>A
- NM_001407590.1:c.5134+1G>A
- NM_001407591.1:c.5134+1G>A
- NM_001407593.1:c.5074+1G>A
- NM_001407594.1:c.5074+1G>A
- NM_001407596.1:c.5074+1G>A
- NM_001407597.1:c.5074+1G>A
- NM_001407598.1:c.5074+1G>A
- NM_001407602.1:c.5074+1G>A
- NM_001407603.1:c.5074+1G>A
- NM_001407605.1:c.5074+1G>A
- NM_001407610.1:c.5071+1G>A
- NM_001407611.1:c.5071+1G>A
- NM_001407612.1:c.5071+1G>A
- NM_001407613.1:c.5071+1G>A
- NM_001407614.1:c.5071+1G>A
- NM_001407615.1:c.5071+1G>A
- NM_001407616.1:c.5071+1G>A
- NM_001407617.1:c.5071+1G>A
- NM_001407618.1:c.5071+1G>A
- NM_001407619.1:c.5071+1G>A
- NM_001407620.1:c.5071+1G>A
- NM_001407621.1:c.5071+1G>A
- NM_001407622.1:c.5071+1G>A
- NM_001407623.1:c.5071+1G>A
- NM_001407624.1:c.5071+1G>A
- NM_001407625.1:c.5071+1G>A
- NM_001407626.1:c.5071+1G>A
- NM_001407627.1:c.5068+1G>A
- NM_001407628.1:c.5068+1G>A
- NM_001407629.1:c.5068+1G>A
- NM_001407630.1:c.5068+1G>A
- NM_001407631.1:c.5068+1G>A
- NM_001407632.1:c.5068+1G>A
- NM_001407633.1:c.5068+1G>A
- NM_001407634.1:c.5068+1G>A
- NM_001407635.1:c.5068+1G>A
- NM_001407636.1:c.5068+1G>A
- NM_001407637.1:c.5068+1G>A
- NM_001407638.1:c.5068+1G>A
- NM_001407639.1:c.5068+1G>A
- NM_001407640.1:c.5068+1G>A
- NM_001407641.1:c.5068+1G>A
- NM_001407642.1:c.5068+1G>A
- NM_001407644.1:c.5065+1G>A
- NM_001407645.1:c.5065+1G>A
- NM_001407646.1:c.5062+1G>A
- NM_001407647.1:c.5059+1G>A
- NM_001407648.1:c.5017+1G>A
- NM_001407649.1:c.5014+1G>A
- NM_001407652.1:c.5074+1G>A
- NM_001407653.1:c.4996+1G>A
- NM_001407654.1:c.4996+1G>A
- NM_001407655.1:c.4996+1G>A
- NM_001407656.1:c.4993+1G>A
- NM_001407657.1:c.4993+1G>A
- NM_001407658.1:c.4993+1G>A
- NM_001407659.1:c.4990+1G>A
- NM_001407660.1:c.4990+1G>A
- NM_001407661.1:c.4990+1G>A
- NM_001407662.1:c.4990+1G>A
- NM_001407663.1:c.4990+1G>A
- NM_001407664.1:c.4951+1G>A
- NM_001407665.1:c.4951+1G>A
- NM_001407666.1:c.4951+1G>A
- NM_001407667.1:c.4951+1G>A
- NM_001407668.1:c.4951+1G>A
- NM_001407669.1:c.4951+1G>A
- NM_001407670.1:c.4948+1G>A
- NM_001407671.1:c.4948+1G>A
- NM_001407672.1:c.4948+1G>A
- NM_001407673.1:c.4948+1G>A
- NM_001407674.1:c.4948+1G>A
- NM_001407675.1:c.4948+1G>A
- NM_001407676.1:c.4948+1G>A
- NM_001407677.1:c.4948+1G>A
- NM_001407678.1:c.4948+1G>A
- NM_001407679.1:c.4948+1G>A
- NM_001407680.1:c.4948+1G>A
- NM_001407681.1:c.4945+1G>A
- NM_001407682.1:c.4945+1G>A
- NM_001407683.1:c.4945+1G>A
- NM_001407684.1:c.5074+1G>A
- NM_001407685.1:c.4945+1G>A
- NM_001407686.1:c.4945+1G>A
- NM_001407687.1:c.4945+1G>A
- NM_001407688.1:c.4945+1G>A
- NM_001407689.1:c.4945+1G>A
- NM_001407690.1:c.4942+1G>A
- NM_001407691.1:c.4942+1G>A
- NM_001407692.1:c.4933+1G>A
- NM_001407694.1:c.4933+1G>A
- NM_001407695.1:c.4933+1G>A
- NM_001407696.1:c.4933+1G>A
- NM_001407697.1:c.4933+1G>A
- NM_001407698.1:c.4933+1G>A
- NM_001407724.1:c.4933+1G>A
- NM_001407725.1:c.4933+1G>A
- NM_001407726.1:c.4933+1G>A
- NM_001407727.1:c.4933+1G>A
- NM_001407728.1:c.4933+1G>A
- NM_001407729.1:c.4933+1G>A
- NM_001407730.1:c.4933+1G>A
- NM_001407731.1:c.4933+1G>A
- NM_001407732.1:c.4930+1G>A
- NM_001407733.1:c.4930+1G>A
- NM_001407734.1:c.4930+1G>A
- NM_001407735.1:c.4930+1G>A
- NM_001407736.1:c.4930+1G>A
- NM_001407737.1:c.4930+1G>A
- NM_001407738.1:c.4930+1G>A
- NM_001407739.1:c.4930+1G>A
- NM_001407740.1:c.4930+1G>A
- NM_001407741.1:c.4930+1G>A
- NM_001407742.1:c.4930+1G>A
- NM_001407743.1:c.4930+1G>A
- NM_001407744.1:c.4930+1G>A
- NM_001407745.1:c.4930+1G>A
- NM_001407746.1:c.4930+1G>A
- NM_001407747.1:c.4930+1G>A
- NM_001407748.1:c.4930+1G>A
- NM_001407749.1:c.4930+1G>A
- NM_001407750.1:c.4930+1G>A
- NM_001407751.1:c.4930+1G>A
- NM_001407752.1:c.4930+1G>A
- NM_001407838.1:c.4927+1G>A
- NM_001407839.1:c.4927+1G>A
- NM_001407841.1:c.4927+1G>A
- NM_001407842.1:c.4927+1G>A
- NM_001407843.1:c.4927+1G>A
- NM_001407844.1:c.4927+1G>A
- NM_001407845.1:c.4927+1G>A
- NM_001407846.1:c.4927+1G>A
- NM_001407847.1:c.4927+1G>A
- NM_001407848.1:c.4927+1G>A
- NM_001407849.1:c.4927+1G>A
- NM_001407850.1:c.4927+1G>A
- NM_001407851.1:c.4927+1G>A
- NM_001407852.1:c.4927+1G>A
- NM_001407853.1:c.4927+1G>A
- NM_001407854.1:c.5074+1G>A
- NM_001407858.1:c.5071+1G>A
- NM_001407859.1:c.5071+1G>A
- NM_001407860.1:c.5071+1G>A
- NM_001407861.1:c.5068+1G>A
- NM_001407862.1:c.4873+1G>A
- NM_001407863.1:c.4948+1G>A
- NM_001407874.1:c.4867+1G>A
- NM_001407875.1:c.4867+1G>A
- NM_001407879.1:c.4864+1G>A
- NM_001407881.1:c.4864+1G>A
- NM_001407882.1:c.4864+1G>A
- NM_001407884.1:c.4864+1G>A
- NM_001407885.1:c.4864+1G>A
- NM_001407886.1:c.4864+1G>A
- NM_001407887.1:c.4864+1G>A
- NM_001407889.1:c.4864+1G>A
- NM_001407894.1:c.4861+1G>A
- NM_001407895.1:c.4861+1G>A
- NM_001407896.1:c.4861+1G>A
- NM_001407897.1:c.4861+1G>A
- NM_001407898.1:c.4861+1G>A
- NM_001407899.1:c.4861+1G>A
- NM_001407900.1:c.4861+1G>A
- NM_001407902.1:c.4861+1G>A
- NM_001407904.1:c.4861+1G>A
- NM_001407906.1:c.4861+1G>A
- NM_001407907.1:c.4861+1G>A
- NM_001407908.1:c.4861+1G>A
- NM_001407909.1:c.4861+1G>A
- NM_001407910.1:c.4861+1G>A
- NM_001407915.1:c.4858+1G>A
- NM_001407916.1:c.4858+1G>A
- NM_001407917.1:c.4858+1G>A
- NM_001407918.1:c.4858+1G>A
- NM_001407919.1:c.4951+1G>A
- NM_001407920.1:c.4810+1G>A
- NM_001407921.1:c.4810+1G>A
- NM_001407922.1:c.4810+1G>A
- NM_001407923.1:c.4810+1G>A
- NM_001407924.1:c.4810+1G>A
- NM_001407925.1:c.4810+1G>A
- NM_001407926.1:c.4810+1G>A
- NM_001407927.1:c.4807+1G>A
- NM_001407928.1:c.4807+1G>A
- NM_001407929.1:c.4807+1G>A
- NM_001407930.1:c.4807+1G>A
- NM_001407931.1:c.4807+1G>A
- NM_001407932.1:c.4807+1G>A
- NM_001407933.1:c.4807+1G>A
- NM_001407934.1:c.4804+1G>A
- NM_001407935.1:c.4804+1G>A
- NM_001407936.1:c.4804+1G>A
- NM_001407937.1:c.4951+1G>A
- NM_001407938.1:c.4951+1G>A
- NM_001407939.1:c.4948+1G>A
- NM_001407940.1:c.4948+1G>A
- NM_001407941.1:c.4945+1G>A
- NM_001407942.1:c.4933+1G>A
- NM_001407943.1:c.4930+1G>A
- NM_001407944.1:c.4930+1G>A
- NM_001407945.1:c.4930+1G>A
- NM_001407946.1:c.4741+1G>A
- NM_001407947.1:c.4741+1G>A
- NM_001407948.1:c.4741+1G>A
- NM_001407949.1:c.4741+1G>A
- NM_001407950.1:c.4738+1G>A
- NM_001407951.1:c.4738+1G>A
- NM_001407952.1:c.4738+1G>A
- NM_001407953.1:c.4738+1G>A
- NM_001407954.1:c.4738+1G>A
- NM_001407955.1:c.4738+1G>A
- NM_001407956.1:c.4735+1G>A
- NM_001407957.1:c.4735+1G>A
- NM_001407958.1:c.4735+1G>A
- NM_001407959.1:c.4693+1G>A
- NM_001407960.1:c.4690+1G>A
- NM_001407962.1:c.4690+1G>A
- NM_001407963.1:c.4687+1G>A
- NM_001407964.1:c.4612+1G>A
- NM_001407965.1:c.4567+1G>A
- NM_001407966.1:c.4186+1G>A
- NM_001407967.1:c.4183+1G>A
- NM_001407968.1:c.2470+1G>A
- NM_001407969.1:c.2467+1G>A
- NM_001407970.1:c.1831+1G>A
- NM_001407971.1:c.1831+1G>A
- NM_001407972.1:c.1828+1G>A
- NM_001407973.1:c.1765+1G>A
- NM_001407974.1:c.1765+1G>A
- NM_001407975.1:c.1765+1G>A
- NM_001407976.1:c.1765+1G>A
- NM_001407977.1:c.1765+1G>A
- NM_001407978.1:c.1765+1G>A
- NM_001407979.1:c.1762+1G>A
- NM_001407980.1:c.1762+1G>A
- NM_001407981.1:c.1762+1G>A
- NM_001407982.1:c.1762+1G>A
- NM_001407983.1:c.1762+1G>A
- NM_001407984.1:c.1762+1G>A
- NM_001407985.1:c.1762+1G>A
- NM_001407986.1:c.1762+1G>A
- NM_001407990.1:c.1762+1G>A
- NM_001407991.1:c.1762+1G>A
- NM_001407992.1:c.1762+1G>A
- NM_001407993.1:c.1762+1G>A
- NM_001408392.1:c.1759+1G>A
- NM_001408396.1:c.1759+1G>A
- NM_001408397.1:c.1759+1G>A
- NM_001408398.1:c.1759+1G>A
- NM_001408399.1:c.1759+1G>A
- NM_001408400.1:c.1759+1G>A
- NM_001408401.1:c.1759+1G>A
- NM_001408402.1:c.1759+1G>A
- NM_001408403.1:c.1759+1G>A
- NM_001408404.1:c.1759+1G>A
- NM_001408406.1:c.1756+1G>A
- NM_001408407.1:c.1756+1G>A
- NM_001408408.1:c.1756+1G>A
- NM_001408409.1:c.1753+1G>A
- NM_001408410.1:c.1690+1G>A
- NM_001408411.1:c.1687+1G>A
- NM_001408412.1:c.1684+1G>A
- NM_001408413.1:c.1684+1G>A
- NM_001408414.1:c.1684+1G>A
- NM_001408415.1:c.1684+1G>A
- NM_001408416.1:c.1684+1G>A
- NM_001408418.1:c.1648+1G>A
- NM_001408419.1:c.1648+1G>A
- NM_001408420.1:c.1648+1G>A
- NM_001408421.1:c.1645+1G>A
- NM_001408422.1:c.1645+1G>A
- NM_001408423.1:c.1645+1G>A
- NM_001408424.1:c.1645+1G>A
- NM_001408425.1:c.1642+1G>A
- NM_001408426.1:c.1642+1G>A
- NM_001408427.1:c.1642+1G>A
- NM_001408428.1:c.1642+1G>A
- NM_001408429.1:c.1642+1G>A
- NM_001408430.1:c.1642+1G>A
- NM_001408431.1:c.1642+1G>A
- NM_001408432.1:c.1639+1G>A
- NM_001408433.1:c.1639+1G>A
- NM_001408434.1:c.1639+1G>A
- NM_001408435.1:c.1639+1G>A
- NM_001408436.1:c.1639+1G>A
- NM_001408437.1:c.1639+1G>A
- NM_001408438.1:c.1639+1G>A
- NM_001408439.1:c.1639+1G>A
- NM_001408440.1:c.1639+1G>A
- NM_001408441.1:c.1639+1G>A
- NM_001408442.1:c.1639+1G>A
- NM_001408443.1:c.1639+1G>A
- NM_001408444.1:c.1639+1G>A
- NM_001408445.1:c.1636+1G>A
- NM_001408446.1:c.1636+1G>A
- NM_001408447.1:c.1636+1G>A
- NM_001408448.1:c.1636+1G>A
- NM_001408450.1:c.1636+1G>A
- NM_001408451.1:c.1630+1G>A
- NM_001408452.1:c.1624+1G>A
- NM_001408453.1:c.1624+1G>A
- NM_001408454.1:c.1624+1G>A
- NM_001408455.1:c.1624+1G>A
- NM_001408456.1:c.1624+1G>A
- NM_001408457.1:c.1624+1G>A
- NM_001408458.1:c.1621+1G>A
- NM_001408459.1:c.1621+1G>A
- NM_001408460.1:c.1621+1G>A
- NM_001408461.1:c.1621+1G>A
- NM_001408462.1:c.1621+1G>A
- NM_001408463.1:c.1621+1G>A
- NM_001408464.1:c.1621+1G>A
- NM_001408465.1:c.1621+1G>A
- NM_001408466.1:c.1621+1G>A
- NM_001408467.1:c.1621+1G>A
- NM_001408468.1:c.1618+1G>A
- NM_001408469.1:c.1618+1G>A
- NM_001408470.1:c.1618+1G>A
- NM_001408472.1:c.1762+1G>A
- NM_001408473.1:c.1759+1G>A
- NM_001408474.1:c.1564+1G>A
- NM_001408475.1:c.1561+1G>A
- NM_001408476.1:c.1561+1G>A
- NM_001408478.1:c.1555+1G>A
- NM_001408479.1:c.1555+1G>A
- NM_001408480.1:c.1555+1G>A
- NM_001408481.1:c.1552+1G>A
- NM_001408482.1:c.1552+1G>A
- NM_001408483.1:c.1552+1G>A
- NM_001408484.1:c.1552+1G>A
- NM_001408485.1:c.1552+1G>A
- NM_001408489.1:c.1552+1G>A
- NM_001408490.1:c.1552+1G>A
- NM_001408491.1:c.1552+1G>A
- NM_001408492.1:c.1549+1G>A
- NM_001408493.1:c.1549+1G>A
- NM_001408494.1:c.1525+1G>A
- NM_001408495.1:c.1519+1G>A
- NM_001408496.1:c.1501+1G>A
- NM_001408497.1:c.1501+1G>A
- NM_001408498.1:c.1501+1G>A
- NM_001408499.1:c.1501+1G>A
- NM_001408500.1:c.1501+1G>A
- NM_001408501.1:c.1501+1G>A
- NM_001408502.1:c.1498+1G>A
- NM_001408503.1:c.1498+1G>A
- NM_001408504.1:c.1498+1G>A
- NM_001408505.1:c.1495+1G>A
- NM_001408506.1:c.1438+1G>A
- NM_001408507.1:c.1435+1G>A
- NM_001408508.1:c.1426+1G>A
- NM_001408509.1:c.1423+1G>A
- NM_001408510.1:c.1384+1G>A
- NM_001408511.1:c.1381+1G>A
- NM_001408512.1:c.1261+1G>A
- NM_001408513.1:c.1234+1G>A
- NM_001408514.1:c.839-3656G>A
- NM_007294.4:c.5074+1G>AMANE SELECT
- NM_007297.4:c.4933+1G>A
- NM_007298.4:c.1762+1G>A
- NM_007299.4:c.1762+1G>A
- NM_007300.4:c.5137+1G>A
- LRG_292t1:c.5074+1G>A
- LRG_292:g.150377G>A
- NC_000017.10:g.41219624C>T
- NM_007294.3:c.5074+1G>A
- NM_007300.3:c.5137+1G>A
- U14680.1:n.5193+1G>A
This HGVS expression did not pass validation- Nucleotide change:
- IVS17+1G>A
- Links:
- BRCA1-HCI: BRCA1_00122; Breast Cancer Information Core (BIC) (BRCA1): 5193+1&base_change=G to A; dbSNP: rs80358053
- NCBI 1000 Genomes Browser:
- rs80358053
- Molecular consequence:
- NM_001408514.1:c.839-3656G>A - intron variant - [Sequence Ontology: SO:0001627]
- NM_001407571.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407581.1:c.5140+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407582.1:c.5140+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407583.1:c.5137+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407585.1:c.5137+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407587.1:c.5137+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407590.1:c.5134+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407591.1:c.5134+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407593.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407594.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407596.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407597.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407598.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407602.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407603.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407605.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407610.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407611.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407612.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407613.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407614.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407615.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407616.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407617.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407618.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407619.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407620.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407621.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407622.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407623.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407624.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407625.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407626.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407627.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407628.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407629.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407630.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407631.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407632.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407633.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407634.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407635.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407636.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407637.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407638.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407639.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407640.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407641.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407642.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407644.1:c.5065+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407645.1:c.5065+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407646.1:c.5062+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407647.1:c.5059+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407648.1:c.5017+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407649.1:c.5014+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407652.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407653.1:c.4996+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407654.1:c.4996+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407655.1:c.4996+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407656.1:c.4993+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407657.1:c.4993+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407658.1:c.4993+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407659.1:c.4990+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407660.1:c.4990+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407661.1:c.4990+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407662.1:c.4990+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407663.1:c.4990+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407664.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407665.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407666.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407667.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407668.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407669.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407670.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407671.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407672.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407673.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407674.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407675.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407676.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407677.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407678.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407679.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407680.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407681.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407682.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407683.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407684.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407685.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407686.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407687.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407688.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407689.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407690.1:c.4942+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407691.1:c.4942+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407692.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407694.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407695.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407696.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407697.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407698.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407724.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407725.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407726.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407727.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407728.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407729.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407730.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407731.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407732.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407733.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407734.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407735.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407736.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407737.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407738.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407739.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407740.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407741.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407742.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407743.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407744.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407745.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407746.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407747.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407748.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407749.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407750.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407751.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407752.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407838.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407839.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407841.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407842.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407843.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407844.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407845.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407846.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407847.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407848.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407849.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407850.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407851.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407852.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407853.1:c.4927+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407854.1:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407858.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407859.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407860.1:c.5071+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407861.1:c.5068+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407862.1:c.4873+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407863.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407874.1:c.4867+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407875.1:c.4867+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407879.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407881.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407882.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407884.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407885.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407886.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407887.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407889.1:c.4864+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407894.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407895.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407896.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407897.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407898.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407899.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407900.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407902.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407904.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407906.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407907.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407908.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407909.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407910.1:c.4861+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407915.1:c.4858+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407916.1:c.4858+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407917.1:c.4858+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407918.1:c.4858+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407919.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407920.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407921.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407922.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407923.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407924.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407925.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407926.1:c.4810+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407927.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407928.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407929.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407930.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407931.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407932.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407933.1:c.4807+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407934.1:c.4804+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407935.1:c.4804+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407936.1:c.4804+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407937.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407938.1:c.4951+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407939.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407940.1:c.4948+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407941.1:c.4945+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407942.1:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407943.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407944.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407945.1:c.4930+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407946.1:c.4741+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407947.1:c.4741+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407948.1:c.4741+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407949.1:c.4741+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407950.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407951.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407952.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407953.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407954.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407955.1:c.4738+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407956.1:c.4735+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407957.1:c.4735+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407958.1:c.4735+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407959.1:c.4693+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407960.1:c.4690+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407962.1:c.4690+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407963.1:c.4687+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407964.1:c.4612+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407965.1:c.4567+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407966.1:c.4186+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407967.1:c.4183+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407968.1:c.2470+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407969.1:c.2467+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407970.1:c.1831+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407971.1:c.1831+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407972.1:c.1828+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407973.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407974.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407975.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407976.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407977.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407978.1:c.1765+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407979.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407980.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407981.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407982.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407983.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407984.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407985.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407986.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407990.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407991.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407992.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001407993.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408392.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408396.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408397.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408398.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408399.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408400.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408401.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408402.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408403.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408404.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408406.1:c.1756+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408407.1:c.1756+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408408.1:c.1756+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408409.1:c.1753+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408410.1:c.1690+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408411.1:c.1687+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408412.1:c.1684+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408413.1:c.1684+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408414.1:c.1684+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408415.1:c.1684+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408416.1:c.1684+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408418.1:c.1648+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408419.1:c.1648+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408420.1:c.1648+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408421.1:c.1645+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408422.1:c.1645+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408423.1:c.1645+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408424.1:c.1645+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408425.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408426.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408427.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408428.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408429.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408430.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408431.1:c.1642+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408432.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408433.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408434.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408435.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408436.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408437.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408438.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408439.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408440.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408441.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408442.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408443.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408444.1:c.1639+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408445.1:c.1636+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408446.1:c.1636+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408447.1:c.1636+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408448.1:c.1636+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408450.1:c.1636+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408451.1:c.1630+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408452.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408453.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408454.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408455.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408456.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408457.1:c.1624+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408458.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408459.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408460.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408461.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408462.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408463.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408464.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408465.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408466.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408467.1:c.1621+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408468.1:c.1618+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408469.1:c.1618+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408470.1:c.1618+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408472.1:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408473.1:c.1759+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408474.1:c.1564+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408475.1:c.1561+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408476.1:c.1561+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408478.1:c.1555+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408479.1:c.1555+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408480.1:c.1555+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408481.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408482.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408483.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408484.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408485.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408489.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408490.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408491.1:c.1552+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408492.1:c.1549+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408493.1:c.1549+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408494.1:c.1525+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408495.1:c.1519+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408496.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408497.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408498.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408499.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408500.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408501.1:c.1501+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408502.1:c.1498+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408503.1:c.1498+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408504.1:c.1498+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408505.1:c.1495+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408506.1:c.1438+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408507.1:c.1435+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408508.1:c.1426+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408509.1:c.1423+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408510.1:c.1384+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408511.1:c.1381+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408512.1:c.1261+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_001408513.1:c.1234+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_007294.4:c.5074+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_007297.4:c.4933+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_007298.4:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_007299.4:c.1762+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- NM_007300.4:c.5137+1G>A - splice donor variant - [Sequence Ontology: SO:0001575]
- Functional consequence:
- functionally_abnormal [Sequence Ontology: SO:0002218] - Comment(s)
- The saturation genome editing (SGE) assay for BRCA1 NM_007294.3:c.5074+1G>A, a CANONICAL SPLICE variant, produced a function score of -2.3, corresponding to a functional classification of LOSS_OF_FUNCTION. SGE function score ranges for classification are as follows: ‘functional’, score > -0.748; ‘intermediate’, -0.748 > score > -1.328; ‘non-functional’, score < -1.328. The median synonymous SNV scored 0.0 and the median nonsense SNV scored -2.12.
- Observations:
- 11
Condition(s)
-
uncharacterized protein [Saccharomyces cerevisiae S288C]
uncharacterized protein [Saccharomyces cerevisiae S288C]Gene ID:850673Gene
-
Human DNA sequence from clone RP11-723P2 on chromosome X, complete sequence
Human DNA sequence from clone RP11-723P2 on chromosome X, complete sequencegi|22002718|emb|AL732326.4|Nucleotide
-
Taxonomy Links for Nucleotide (Select 1486587563) (1)
Taxonomy
-
Taxonomy Links for Protein (Select 189066554) (1)
Taxonomy
-
Taxonomy Links for Protein (Select 62897113) (1)
Taxonomy
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See more...Assertion and evidence details
Submission Accession | Submitter | Review Status (Assertion method) | Clinical Significance (Last evaluated) | Origin | Method | Citations |
---|---|---|---|---|---|---|
SCV000053810 | Sharing Clinical Reports Project (SCRP) | no assertion criteria provided | Pathogenic (Mar 5, 2012) | germline | clinical testing | |
SCV000145288 | Breast Cancer Information Core (BIC) (BRCA1) | no assertion criteria provided | Pathogenic (Feb 20, 2004) | germline | clinical testing | |
SCV000244381 | Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) | reviewed by expert panel (ENIGMA BRCA1/2 Classification Criteria (2015)) | Pathogenic (Aug 10, 2015) | germline | curation | PubMed (1) ENIGMA BRCA1/2 Classification Criteria (2015), |
SCV000296376 | Quest Diagnostics Nichols Institute San Juan Capistrano | criteria provided, single submitter (Quest Diagnostics criteria) | Pathogenic (Aug 21, 2015) | germline | clinical testing | |
SCV000326131 | Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), c/o University of Cambridge | criteria provided, single submitter (CIMBA Mutation Classification guidelines May 2016) | Pathogenic (Oct 2, 2015) | germline | clinical testing | CIMBA_Mutation_Classification_guidelines_May16.pdf, |
SCV001237533 | Brotman Baty Institute, University of Washington | no classification provided | not provided | not applicable | in vitro | |
SCV004047090 | Neuberg Centre For Genomic Medicine, NCGM | criteria provided, single submitter (ACMG Guidelines, 2015) | Pathogenic | germline | clinical testing | |
SCV004216950 | Baylor Genetics | criteria provided, single submitter (ACMG Guidelines, 2015) | Pathogenic (Jun 9, 2022) | unknown | clinical testing | |
SCV004243954 | BRCAlab, Lund University | no assertion criteria provided | Pathogenic (Mar 2, 2020) | germline | clinical testing | |
SCV004930336 | Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics | criteria provided, single submitter (ACMG Guidelines, 2015) | Pathogenic (Apr 19, 2024) | germline | clinical testing | |
SCV005373469 | KCCC/NGS Laboratory, Kuwait Cancer Control Center | criteria provided, single submitter (ACMG Guidelines, 2015) | Pathogenic (Oct 9, 2024) | germline | clinical testing |
Summary from all submissions
Ethnicity | Origin | Affected | Individuals | Families | Chromosomes tested | Number Tested | Family history | Method |
---|---|---|---|---|---|---|---|---|
not provided | germline | yes | 4 | not provided | not provided | not provided | not provided | clinical testing |
not provided | germline | not provided | 3 | not provided | not provided | 3 | not provided | clinical testing |
not provided | germline | unknown | not provided | 11 | not provided | not provided | not provided | clinical testing, curation |
not provided | not applicable | not applicable | not provided | not provided | not provided | not provided | not provided | in vitro |
not provided | unknown | unknown | not provided | not provided | not provided | not provided | not provided | clinical testing |
Asian | germline | yes | 1 | not provided | not provided | not provided | not provided | clinical testing |
Citations
PubMed
Easton DF, Deffenbaugh AM, Pruss D, Frye C, Wenstrup RJ, Allen-Brady K, Tavtigian SV, Monteiro AN, Iversen ES, Couch FJ, Goldgar DE.
Am J Hum Genet. 2007 Nov;81(5):873-83. Epub 2007 Sep 6.
- PMID:
- 17924331
- PMCID:
- PMC2265654
Lindor NM, Guidugli L, Wang X, Vallée MP, Monteiro AN, Tavtigian S, Goldgar DE, Couch FJ.
Hum Mutat. 2012 Jan;33(1):8-21. doi: 10.1002/humu.21627. Epub 2011 Nov 3. Review.
- PMID:
- 21990134
- PMCID:
- PMC3242438
Details of each submission
From Sharing Clinical Reports Project (SCRP), SCV000053810.6
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | not provided |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | not provided | 3 | not provided | not provided | not provided | not provided | not provided | See 1 |
Co-occurrences
# | Zygosity | Alleles | Number of Observations |
---|---|---|---|
1 | SingleHeterozygote | BRCA2:5323G>A (D1699N) | 1 |
From Breast Cancer Information Core (BIC) (BRCA1), SCV000145288.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | 2 | not provided | not provided | clinical testing | not provided |
2 | Asian | 1 | not provided | not provided | clinical testing | not provided |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | yes | not provided | not provided | not provided | 2 | not provided | not provided | not provided | |
2 | germline | yes | not provided | not provided | not provided | 1 | not provided | not provided | not provided |
From Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA), SCV000244381.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | curation | PubMed (1) |
Description
IARC class based on posterior probability from multifactorial likelihood analysis, thresholds for class as per Plon et al. 2008 (PMID: 18951446). Class 5 based on posterior probability = 1
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | unknown | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From Quest Diagnostics Nichols Institute San Juan Capistrano, SCV000296376.2
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | PubMed (4) |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | unknown | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA), c/o University of Cambridge, SCV000326131.4
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | not provided |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | unknown | not provided | not provided | not provided | not provided | not provided | 11 | not provided |
From Brotman Baty Institute, University of Washington, SCV001237533.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | in vitro | PubMed (1) |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | not applicable | not applicable | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From Neuberg Centre For Genomic Medicine, NCGM, SCV004047090.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | PubMed (1) |
Description
The invariant splice site c.5074+1G>A variant has been reported previously in heterozygous state in individuals affected with Hereditary Breast And Ovarian Cancer Syndrome (Singh J et al). The variant is novel (not in any individuals) in gnomAD and in 1000 Genomes. This sequence change affects a donor splice site in intron 16 of the BRCA1 gene. It is expected to disrupt RNA splicing and likely results in an absent or disrupted protein product. Multifactorial likelihood analyses based on genetic evidence such as family history, co-segregation with disease, and co-occurrence with pathogenic variants predict that this variant is likely deleterious (Easton DF et al). Donor and acceptor splice site variants typically lead to a loss of protein function and loss-of-function variants in BRCA1 are known to be pathogenic (Baralle D et al). For these reasons, this variant has been classified as Pathogenic.
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | yes | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From Baylor Genetics, SCV004216950.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | PubMed (1) |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | unknown | unknown | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From BRCAlab, Lund University, SCV004243954.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | not provided | not provided | not provided | not provided | clinical testing | not provided |
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | yes | not provided | not provided | not provided | not provided | not provided | not provided | not provided |
From Foundation for Research in Genetics and Endocrinology, FRIGE's Institute of Human Genetics, SCV004930336.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | 1 | not provided | not provided | clinical testing | PubMed (1) |
Description
A heterozygous 5' splice site variation in intron 16 of the BRCA1 gene that affects the invariant GT donor splice site of exon 16 (c.5074+1G>A). The observed variation (also known as IVS17+1G>A) has been previously reported in multiple breast and ovarian cancer patients [PMID: 29470806, 31528241, 17924331]. The variant has not been reported in the 1000 genomes, gnomAD V3.0 and gnomAD V2.1 databases. The in-silico prediction of the variant is damaging by Mutation Taster 2 tool. The reference base is conserved across mammals. In summary, the variant meets our criteria to be classified as pathogenic.
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | yes | not provided | not provided | not provided | 1 | not provided | not provided | not provided |
From KCCC/NGS Laboratory, Kuwait Cancer Control Center, SCV005373469.1
# | Ethnicity | Individuals | Chromosomes Tested | Family History | Method | Citations |
---|---|---|---|---|---|---|
1 | 1 | not provided | not provided | clinical testing | PubMed (1) |
Description
This sequence change affects a donor splice site in intron 16 of the BRCA1 gene. RNA analysis indicates that disruption of this splice site induces altered splicing and may result in an absent or disrupted protein product. This variant is present in population databases (rs80358053, gnomAD 0.003%). Disruption of this splice site has been observed in individual(s) with triple-negative breast cancer (PMID: PMID: 17924331, 23593081, 25525159, 25724305, 22752604, 26911350, 27553291, 29470806, 29446198, 30209399, 31706072, 30093976, 31372034, 31528241, 31161121, 21990134, 27535533, 32341426, 32885271). This variant is also known as c.5074+1G>A . ClinVar contains an entry for this variant (Variation ID: 37629). In silico splice site analysis predicts that this alteration will weaken the native splice donor site. Experimental studies have shown that disruption of this splice site affects BRCA1 function (PMID: 30209399). Studies have shown that disruption of this splice site results in skipping of exon 16 and introduces a premature termination codon . The resulting mRNA is expected to undergo nonsense-mediated decay. For these reasons, this variant has been classified as Pathogenic.
# | Sample | Method | Observation | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Origin | Affected | Number tested | Tissue | Purpose | Method | Individuals | Allele frequency | Families | Co-occurrences | |
1 | germline | yes | not provided | not provided | not provided | 1 | not provided | not provided | not provided |
Last Updated: Oct 26, 2024