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Items: 80

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
PEX10
(E279K +4 more)
Single nucleotide variant
(missense variant +1 more)
Peroxisome biogenesis disorder, complementation group 7
GUncertain significance
ALPL
(E298K +2 more)
Single nucleotide variant
(missense variant)
Childhood hypophosphatasia
+5 more
GPathogenic/Likely pathogenic
MUTYH
(E424K +7 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 2
GUncertain significance
MUTYH
(E172K +7 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 2
+1 more
GUncertain significance
CASQ1
(E298K)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
SUCO
(E335K +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
LEFTY2
(E298K +1 more)
Single nucleotide variant
(missense variant)
Left-right axis malformations
GUncertain significance
COQ8A
(E298K)
Single nucleotide variant
(missense variant)
not specified
+1 more
GUncertain significance
SDCCAG8
(E396K +3 more)
Single nucleotide variant
(missense variant)
Senior-Loken syndrome 7
+1 more
GUncertain significance
LPIN1
(E298K +6 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
GDF7
(E298K)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
SPAST
(E298K +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
MSH2
(E364K +1 more)
Single nucleotide variant
(missense variant)
Hereditary nonpolyposis colorectal neoplasms
+1 more
GUncertain significance
XIRP2
(E265K +2 more)
Single nucleotide variant
(missense variant)
not provided
GLikely benign
BARD1
(E317K +1 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
+1 more
GUncertain significance
NEK10
(E298K +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
MLH1
(E331K +3 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+6 more
GUncertain significance
MAP4
(E204K +16 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
SEMA3F
(E230K +2 more)
Single nucleotide variant
(missense variant)
SEMA3F-related disorder
GUncertain significance
RFT1
(E298K)
Single nucleotide variant
(missense variant)
RFT1-congenital disorder of glycosylation
GPathogenic
WNT5A
(E313K +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
SERPINI1
(E298K)
Single nucleotide variant
(missense variant)
Familial encephalopathy with neuroserpin inclusion bodies
GUncertain significance
PDGFRA
(E311K +2 more)
Single nucleotide variant
(missense variant)
Gastrointestinal stromal tumor
GUncertain significance
MFSD8
(E392K +8 more)
Single nucleotide variant
(missense variant)
Neuronal ceroid lipofuscinosis 7
+2 more
GUncertain significance
MFSD8
(E336K +8 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
BRD9
(E200K +7 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
WDR70
(E276K +2 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
CTNNA1
(E175K +2 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
RIPK1
(E252K +2 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
TFAP2A
(E290K +2 more)
Single nucleotide variant
(missense variant)
Branchiooculofacial syndrome
GPathogenic
GCNT2
(E298K)
Single nucleotide variant
(missense variant)
GCNT2-related disorder
GLikely benign
PMS2
(E489K +7 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+5 more
GUncertain significance
ZNF12
(E260K +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
POLD2
(E298K)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
RELN
(E298K)
Single nucleotide variant
(missense variant)
Familial temporal lobe epilepsy 7
+1 more
GLikely benign
PRKAG2
(E101K +4 more)
Single nucleotide variant
(missense variant)
not specified
+2 more
GUncertain significance
PEX2
(E298K)
Single nucleotide variant
(missense variant)
Peroxisome biogenesis disorder 5A (Zellweger)
+1 more
GConflicting classifications of pathogenicity
GSDMC
(E298K)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
PLEC
(E290K +6 more)
Single nucleotide variant
(missense variant)
Epidermolysis bullosa simplex 5B, with muscular dystrophy
+5 more
GUncertain significance
ASS1
(E298K)
Single nucleotide variant
(missense variant)
Cardiac arrhythmia
+2 more
GConflicting classifications of pathogenicity
NSMF
(E298K +4 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
OPTN
(E298K)
Single nucleotide variant
(missense variant)
Amyotrophic lateral sclerosis type 12
+2 more
GUncertain significance
NEBL
(E251K +6 more)
Single nucleotide variant
(3 prime UTR variant +1 more)
not specified
+1 more
GUncertain significance
MICU1
(E100K +3 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
KAT6B
(E1079K +7 more)
Single nucleotide variant
(missense variant)
Genitopatellar syndrome
GUncertain significance
ILK, TAF10
(E359K +2 more)
Single nucleotide variant
(missense variant +1 more)
Primary familial hypertrophic cardiomyopathy
GUncertain significance
MTMR2
(E226K +1 more)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 4
GUncertain significance
MCF2L
(E331K +4 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
BCL11B
(E297K +3 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
BTBD6, BRF1
(E245K +1 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
DUOXA1
(E253K +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
LINS1
(E313K +2 more)
Single nucleotide variant
(missense variant +1 more)
Intellectual disability, autosomal recessive 27
GLikely pathogenic
TSC2
(E287K +4 more)
Single nucleotide variant
(missense variant)
Tuberous sclerosis 2
+1 more
GUncertain significance
TSC2
(E498K +4 more)
Single nucleotide variant
(missense variant)
not specified
+3 more
GConflicting classifications of pathogenicity
ABAT
(E277K +7 more)
Single nucleotide variant
(missense variant)
Gamma-aminobutyric acid transaminase deficiency
GUncertain significance
ZNF232
(E231K +6 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
AIPL1
(E298K +6 more)
Single nucleotide variant
(missense variant +1 more)
Leber congenital amaurosis 4
GUncertain significance
TP53
(E166K +3 more)
Single nucleotide variant
(missense variant)
Li-Fraumeni syndrome
GBenign
FLCN
(E280K +1 more)
Single nucleotide variant
(missense variant)
Birt-Hogg-Dube syndrome 1
+2 more
GUncertain significance
ATAD5
(E298K)
Single nucleotide variant
(missense variant)
ATAD5-related disorder
GLikely benign
ADAP2
(E297K +2 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
BRCA1
(E1193K +75 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
GUncertain significance
BRCA1
(E1440K +58 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
GUncertain significance
MILR1, POLG2
(E298K)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
DSG1-AS1, DSG4
(E298K)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
FCER2
(E297K +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
CD22
(E126K +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
ZNF112
(E359K +3 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
DACT3
(E298K +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
SHANK1
(E298K)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
POLR3F
(E250K +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
AIRE
(E298K)
Single nucleotide variant
(missense variant)
Polyglandular autoimmune syndrome, type 1
GUncertain significance
ITGB2
(E298K +1 more)
Single nucleotide variant
(missense variant)
Leukocyte adhesion deficiency 1
GUncertain significance
PCBP3
(E274K +6 more)
Single nucleotide variant
(missense variant +2 more)
not specified
GUncertain significance
RAB36, RSPH14
(E298K +2 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
MRTFA
(E298K +3 more)
Single nucleotide variant
(missense variant)
not provided
GLikely benign
ARSA
(E384K +1 more)
Single nucleotide variant
(missense variant)
Metachromatic leukodystrophy
+1 more
GPathogenic/Likely pathogenic
FRMPD4
(E266K +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
BTK
(E298K +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
SRP72
(E298K +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
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