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Items: 84

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
SAMD11
(G417R +2 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
RPE65
(E417Q)
Single nucleotide variant
(missense variant)
RPE65-related recessive retinopathy
GLikely pathogenic
LMNA
(A417P +5 more)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 2
GLikely pathogenic
GJC2
(A417P)
Single nucleotide variant
(missense variant)
Spastic paraplegia
GUncertain significance
ALK
(V417L)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+1 more
GUncertain significance
NRXN1
(V402L +7 more)
Single nucleotide variant
(missense variant)
NRXN1-related disorder
GUncertain significance
FANCL, VRK2
(D417H +2 more)
Single nucleotide variant
(3 prime UTR variant +1 more)
Fanconi anemia complementation group L
GUncertain significance
DCTN1
(V320L +6 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
DCTN1
(D387H +6 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
PROC
(V409L +9 more)
Single nucleotide variant
(missense variant)
Thrombophilia due to protein C deficiency, autosomal dominant
GUncertain significance
DCAF17
(D417H +1 more)
Single nucleotide variant
(missense variant +1 more)
Inborn genetic diseases
GUncertain significance
COL3A1
(G417R)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, type 4
GLikely pathogenic
RBMS3
(V404L +4 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
MLH1
(E157Q +5 more)
Single nucleotide variant
(missense variant)
Lynch syndrome
GUncertain significance
MAP4
(E230Q +17 more)
Single nucleotide variant
(missense variant +1 more)
MAP4-related disorder
GBenign
DLG1
(V417L +4 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
DTHD1
(D396H +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
ENPEP
(G417R)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
ANK2
(G392R +11 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TERT
(A417P)
Single nucleotide variant
(missense variant +1 more)
Idiopathic Pulmonary Fibrosis
+1 more
GUncertain significance
PAM
(G524R +4 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
APC
(D417H +18 more)
Single nucleotide variant
(missense variant +1 more)
Familial adenomatous polyposis 1
GUncertain significance
ACSL6
(G404R +8 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
PDE6A
(E417Q)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
COL11A2
(G1013R +6 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
PTK7
(A409P +1 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
EYA4, TARID
(D386H +4 more)
Single nucleotide variant
(missense variant)
Dilated cardiomyopathy 1J
+1 more
GUncertain significance
SUN1
(V196L +31 more)
Single nucleotide variant
(missense variant +1 more)
Emery-Dreifuss muscular dystrophy
GUncertain significance
BBS9
(V295L +3 more)
Single nucleotide variant
(missense variant +1 more)
Bardet-Biedl syndrome
GUncertain significance
ELN
(G422R +4 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GUncertain significance
PEX1
(E417Q +1 more)
Single nucleotide variant
(missense variant)
Zellweger spectrum disorders
GUncertain significance
CASD1, SGCE
(A281P +9 more)
Single nucleotide variant
(missense variant)
Myoclonic dystonia 11
+1 more
GUncertain significance
GIGYF1
(G417R)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
BRAF
(G469R +7 more)
Single nucleotide variant
(missense variant)
Cardio-facio-cutaneous syndrome
+1 more
GPathogenic/Likely pathogenic
VIPR2
(G337R +2 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
CSPP1
(G123R +5 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
LRRCC1
(A211P +4 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
NBN
(V335L +1 more)
Single nucleotide variant
(missense variant)
Microcephaly, normal intelligence and immunodeficiency
GUncertain significance
FOXD4
(E417Q)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
STXBP1
(G381R +3 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 4
GPathogenic
PPP1R26
(E417Q)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
LOC126860802, ZMYND11
(V336L +15 more)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
NMT2
(E417Q +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
ANKRD26
(E417Q)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
EGR2
(A467P +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
LRIT1
(E417Q)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
KIF11
(E417Q)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
PDHX
(V477L +2 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GUncertain significance
KMT5B
(E589Q +2 more)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
GLikely benign
R3HDM2
(A425P +11 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
CRY1
(G260R +4 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
TRPV4
(A344P +4 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
TCTN1
(V417L +3 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GConflicting classifications of pathogenicity
TDRD3
(G417R +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
FANCM
(E417Q +1 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GUncertain significance
SPATA7
(V385L +1 more)
Single nucleotide variant
(missense variant)
not specified
+1 more
GUncertain significance
DICER1
(D228H +3 more)
Single nucleotide variant
(missense variant +2 more)
Hereditary cancer-predisposing syndrome
GUncertain significance
KBTBD13
(E417Q)
Single nucleotide variant
(missense variant)
Nemaline myopathy 6
GUncertain significance
SBK1
(A417P)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
TUBB3
(D417H +1 more)
Single nucleotide variant
(missense variant)
Fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement
GPathogenic
SLC13A5
(G434R +2 more)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 25
GUncertain significance
TEKT1
(V417L)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
ACADVL
(G363R +3 more)
Single nucleotide variant
(missense variant)
Very long chain acyl-CoA dehydrogenase deficiency
GLikely pathogenic
BRCA1
(E1829Q +80 more)
Single nucleotide variant
(missense variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 1
Gnot provided
BRCA1
(V1641L +77 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
Gnot provided
BRCA1
(E1411Q +77 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
GUncertain significance
BRCA1
(E1559Q +75 more)
Single nucleotide variant
(missense variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
+3 more
GPathogenic/Likely pathogenic
BRCA1
(D1546H +75 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary breast ovarian cancer syndrome
+1 more
GUncertain significance
BRCA1
(E538Q +20 more)
Single nucleotide variant
(intron variant +1 more)
Hereditary breast ovarian cancer syndrome
+1 more
GConflicting classifications of pathogenicity
BRCA1
(D373H +20 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary breast ovarian cancer syndrome
+1 more
GConflicting classifications of pathogenicity
XYLT2
(D417H)
Single nucleotide variant
(missense variant +1 more)
not provided
GUncertain significance
RNF43
(G290R +1 more)
Single nucleotide variant
(missense variant)
Sessile serrated polyposis cancer syndrome
GUncertain significance
STRADA
(E367Q +4 more)
Single nucleotide variant
(missense variant +2 more)
Polyhydramnios, megalencephaly, and symptomatic epilepsy
GUncertain significance
PIEZO2
(V417L)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
AMH
(G417R)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
ACSBG2, LOC105372255
(G367R +2 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
ZNF404
(G417R)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
CEACAM16, CEACAM16-AS1
(V417L)
Single nucleotide variant
(missense variant)
not specified
+1 more
GBenign/Likely benign
TRPM4
(G237R +4 more)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
GUncertain significance
SLC4A11
(G401R +2 more)
Single nucleotide variant
(missense variant +2 more)
Congenital hereditary endothelial dystrophy of cornea
+3 more
GLikely pathogenic
TSHZ2
(V417L +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
BEND2
(D326H +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
DMD
(E417Q +3 more)
Single nucleotide variant
(missense variant)
Dilated cardiomyopathy 3B
GUncertain significance
ARHGEF9
(V300L +10 more)
Single nucleotide variant
(missense variant +1 more)
Developmental and epileptic encephalopathy, 8
GLikely benign
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