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Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
SKI
(P35S)
Single nucleotide variant
(missense variant)
Shprintzen-Goldberg syndrome
+1 more
GPathogenic
PLOD1
(Q327* +1 more)
Single nucleotide variant
(nonsense)
Ehlers-Danlos syndrome, kyphoscoliotic type 1
+1 more
GPathogenic
PLOD1
(Y511* +1 more)
Single nucleotide variant
(nonsense)
not provided
+3 more
GPathogenic
PLOD1
(I599fs +1 more)
Deletion
(frameshift variant)
Ehlers-Danlos syndrome, kyphoscoliotic type 1
GPathogenic
PLOD1
(G678R +1 more)
Single nucleotide variant
(missense variant)
Ehlers-Danlos syndrome, kyphoscoliotic type 1
GPathogenic/Likely pathogenic
MFN2
(R104W)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b;
+7 more
GPathogenic
MFN2
(R468H)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease
+7 more
GConflicting classifications of pathogenicity
CLCNKB, LOC106501712
Deletion
BARTTER SYNDROME, TYPE 4B, WITH SENSORINEURAL DEAFNESS
GPathogenic
EPHA2
(A959T +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
ATP13A2
(G315R +1 more)
Single nucleotide variant
(missense variant)
Kufor-Rakeb syndrome
+1 more
GConflicting classifications of pathogenicity
ATP13A2
Deletion
(splice acceptor variant)
not provided
+2 more
GConflicting classifications of pathogenicity
SDHB
(R90*)
Single nucleotide variant
(nonsense)
Hereditary cancer-predisposing syndrome
+7 more
GPathogenic
PAX7
Single nucleotide variant
(splice acceptor variant)
Myopathy, congenital, progressive, with scoliosis
GPathogenic
USP48
(T672L +2 more)
Indel
(missense variant)
Hearing loss, autosomal dominant 85
GPathogenic
HSPG2, LDLRAD2
Deletion
(splice acceptor variant +1 more)
Schwartz-Jampel syndrome type 1
GPathogenic
HSPG2
(T1639M +1 more)
Single nucleotide variant
(missense variant)
not specified
+3 more
GConflicting classifications of pathogenicity
HSPG2
(N786S +1 more)
Single nucleotide variant
(missense variant)
not provided
+3 more
GConflicting classifications of pathogenicity
C1QC
(G34R)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GPathogenic
C1QC
(R69*)
Single nucleotide variant
(nonsense +1 more)
not provided
GPathogenic
C1QC
(Q74fs)
Deletion
(frameshift variant +1 more)
not provided
GUncertain significance
C1QB
(R175* +1 more)
Single nucleotide variant
(nonsense)
C1Q deficiency 2
GPathogenic
RHCE
(I171fs +2 more)
Deletion
(frameshift variant +1 more)
RH-NULL, AMORPH TYPE
GPathogenic
DHDDS
(W64*)
Single nucleotide variant
(nonsense +1 more)
Congenital disorder of glycosylation, type Ibb
GPathogenic
ARID1A
(Q450*)
Single nucleotide variant
(nonsense)
Intellectual disability, autosomal dominant 14
+1 more
GPathogenic
ARID1A
(K1828fs +1 more)
Deletion
(frameshift variant)
ARID1A-related BAFopathy
+1 more
GPathogenic
GJB4
(R22C)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
GJB3
(E183K)
Single nucleotide variant
(missense variant)
Erythrokeratodermia variabilis et progressiva 1
+2 more
GConflicting classifications of pathogenicity
RSPO1
Deletion
(splice acceptor variant +2 more)
Palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome
GPathogenic
SLC2A1
(R330*)
Single nucleotide variant
(nonsense)
Inborn genetic diseases
+6 more
GPathogenic
SLC2A1
(R126C)
Single nucleotide variant
(missense variant)
not provided
+3 more
GPathogenic/Likely pathogenic
EIF2B3
(K33E)
Single nucleotide variant
(missense variant)
Vanishing white matter disease
GUncertain significance
HPDL
Single nucleotide variant
(missense variant)
Spastic paraplegia
+1 more
GPathogenic/Likely pathogenic
MUTYH
Single nucleotide variant
(synonymous variant +1 more)
not specified
+3 more
GConflicting classifications of pathogenicity
POMGNT1, TSPAN1
(E251D +2 more)
Single nucleotide variant
(missense variant)
Muscle eye brain disease
+3 more
GUncertain significance
POMGNT1, TSPAN1
(L120R +1 more)
Single nucleotide variant
(missense variant +1 more)
Retinitis pigmentosa 76
GPathogenic
UQCRH
Deletion
(splice acceptor variant +2 more)
Mitochondrial complex 3 deficiency, nuclear type 11
GPathogenic
FAAH, LOC129930482
(P129T)
Single nucleotide variant
(missense variant)
PAIN SENSITIVITY QUANTITATIVE TRAIT LOCUS 1
GAffects
CPT2
(S113L)
Single nucleotide variant
(missense variant)
Encephalopathy, acute, infection-induced, susceptibility to, 4
+7 more
GPathogenic/Likely pathogenic
PARS2
(V95I)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 75
+1 more
GConflicting classifications of pathogenicity
DHCR24
(L167S)
Single nucleotide variant
(missense variant)
Desmosterolosis
GUncertain significance
BSND
Deletion
(splice acceptor variant +1 more)
Bartter disease type 4A
GPathogenic
C8A
(R424*)
Single nucleotide variant
(nonsense)
not provided
GPathogenic
FOXD3, FOXD3-AS1
+1 more
Single nucleotide variant
(non-coding transcript variant)
Autoimmune disease, susceptibility to, 1
Grisk factor
RPE65
(R515W)
Single nucleotide variant
(missense variant)
RPE65-related recessive retinopathy
GPathogenic
ABCA4
(G991R +1 more)
Single nucleotide variant
(missense variant)
Severe early-childhood-onset retinal dystrophy
+4 more
GPathogenic/Likely pathogenic
F3
(S117fs)
Microsatellite
(frameshift variant)
not provided
GUncertain significance
AGL
(T809fs +1 more)
Deletion
(frameshift variant)
Glycogen storage disease type III
GPathogenic
COL11A1
(E1466* +3 more)
Single nucleotide variant
(nonsense +1 more)
Stickler syndrome type 2
GPathogenic
RNPC3
(P474T)
Single nucleotide variant
(missense variant)
Isolated growth hormone deficiency, type 5
+1 more
GPathogenic
CASQ2
(R33*)
Single nucleotide variant
(nonsense)
not provided
+3 more
GPathogenic/Likely pathogenic
HMGCS2
Single nucleotide variant
(splice acceptor variant)
3-hydroxy-3-methylglutaryl-CoA synthase deficiency
GPathogenic
ECM1
Deletion
(splice acceptor variant +1 more)
Lipid proteinosis
GPathogenic
PI4KB
(M422R +3 more)
Single nucleotide variant
(missense variant)
Hearing loss, autosomal dominant 87
GPathogenic
PI4KB
(E350K +3 more)
Single nucleotide variant
(missense variant)
Hearing loss, autosomal dominant 87
GPathogenic
PI4KB
(V117G +3 more)
Single nucleotide variant
(missense variant)
Hearing loss, autosomal dominant 87
GPathogenic
CCDST, FLG
(S761fs)
Microsatellite
(frameshift variant)
not provided
+4 more
GPathogenic/Likely pathogenic
LORICRIN
(Q222fs)
Duplication
(frameshift variant)
Loricrin keratoderma
GPathogenic
TPM3
(S51P +1 more)
Single nucleotide variant
(missense variant +3 more)
Congenital myopathy with fiber type disproportion
+1 more
GUncertain significance
HAX1
(R126W +1 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GUncertain significance
HAX1
(S128* +1 more)
Single nucleotide variant
(nonsense)
Kostmann syndrome
GPathogenic
ASH1L
(R2952fs +1 more)
Duplication
(frameshift variant)
Intellectual disability, autosomal dominant 52
GPathogenic
LMNA
(L38H)
Single nucleotide variant
(missense variant)
Congenital muscular dystrophy due to LMNA mutation
GUncertain significance
LMNA
(R216C +2 more)
Single nucleotide variant
(missense variant)
Primary familial dilated cardiomyopathy
+5 more
GPathogenic/Likely pathogenic
LMNA
(M464K +2 more)
Single nucleotide variant
(missense variant)
Hutchinson-Gilford syndrome
+1 more
GConflicting classifications of pathogenicity
LMNA
(R527P +2 more)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 2
+3 more
GPathogenic
LMNA
(T655fs +2 more)
Duplication
(frameshift variant +1 more)
Primary dilated cardiomyopathy
+4 more
GConflicting classifications of pathogenicity
NTRK1
Single nucleotide variant
(splice acceptor variant)
Hereditary insensitivity to pain with anhidrosis
GPathogenic/Likely pathogenic
NTRK1
Single nucleotide variant
(intron variant)
Hereditary insensitivity to pain with anhidrosis
+2 more
GPathogenic
NTRK1
(R317P +1 more)
Single nucleotide variant
(missense variant)
Hereditary insensitivity to pain with anhidrosis
GLikely pathogenic
ACKR1
(W96fs +1 more)
Deletion
(frameshift variant)
DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE
GPathogenic
ATP1A2
(M813K)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy 98
+1 more
GPathogenic/Likely pathogenic
MPZ
(D224Y)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+1 more
GPathogenic/Likely pathogenic
CFAP126, SDHC
Indel
Paragangliomas 3
GPathogenic
ADCY10, DCAF6
(T142M +2 more)
Single nucleotide variant
(missense variant)
not provided
GBenign
TBX19
(Y209*)
Single nucleotide variant
(nonsense)
Congenital isolated adrenocorticotropic hormone deficiency
+1 more
GPathogenic
LOC129931894, SLC19A2
(P51L)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
SERPINC1
(P439L +6 more)
Single nucleotide variant
(missense variant)
Hereditary antithrombin deficiency
GLikely pathogenic
SERPINC1
(E277fs +6 more)
Microsatellite
(frameshift variant)
Hereditary antithrombin deficiency
GPathogenic
SERPINC1
(E229fs +6 more)
Deletion
(frameshift variant)
Hereditary antithrombin deficiency
GLikely pathogenic
SERPINC1
(R79C +2 more)
Single nucleotide variant
(missense variant)
Hereditary antithrombin deficiency
GPathogenic
AXDND1, NPHS2
(A288T +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+1 more
GConflicting classifications of pathogenicity
CACNA1E
(A702S)
Single nucleotide variant
(missense variant)
Developmental and epileptic encephalopathy, 69
GPathogenic
LAMC2
(T1132fs)
Duplication
(frameshift variant)
Epidermolysis bullosa, junctional 3A, intermediate
GPathogenic
CFHR5
Duplication
(splice acceptor variant +1 more)
C3 glomerulonephritis
GPathogenic
PTPRC
Deletion
(inframe_deletion)
Immunodeficiency 105
GPathogenic
CACNA1S
Single nucleotide variant
(splice acceptor variant)
Malignant hyperthermia, susceptibility to, 5
+1 more
GConflicting classifications of pathogenicity
TNNT2
(K210del +5 more)
Microsatellite
(inframe_deletion)
Cardiovascular phenotype
+6 more
GPathogenic/Likely pathogenic
TNNT2
Single nucleotide variant
(intron variant +1 more)
Cardiomyopathy
+7 more
GConflicting classifications of pathogenicity
TNNT2
(R104C +2 more)
Single nucleotide variant
(missense variant +1 more)
Hypertrophic cardiomyopathy 2
+6 more
GPathogenic/Likely pathogenic
IL10, IL19
Single nucleotide variant
(intron variant)
not provided
+1 more
GBenign
CD46
Single nucleotide variant
(splice donor variant)
Familial Atypical Hemolytic-Uremic Syndrome
+3 more
GPathogenic/Likely pathogenic
LAMB3
(C355R)
Single nucleotide variant
(missense variant)
not provided
+1 more
GPathogenic/Likely pathogenic
IRF6
(R412* +1 more)
Single nucleotide variant
(nonsense)
Orofacial cleft 6, susceptibility to
+4 more
GPathogenic
PTPN14
Deletion
(splice acceptor variant +1 more)
Lymphedema-posterior choanal atresia syndrome
GPathogenic
USH2A
Single nucleotide variant
(intron variant)
not provided
+2 more
GPathogenic/Likely pathogenic
USH2A
(E3448K)
Single nucleotide variant
(missense variant)
Retinal dystrophy
+4 more
GPathogenic/Likely pathogenic
USH2A
(G2224C)
Single nucleotide variant
(missense variant)
Retinitis pigmentosa
+6 more
GUncertain significance
USH2A
(E767fs)
Deletion
(frameshift variant)
Retinitis pigmentosa 39
+22 more
GPathogenic
LBR
(Y468fs)
Deletion
(frameshift variant)
Greenberg dysplasia
GPathogenic
EPHX1
(T275A +2 more)
Single nucleotide variant
(missense variant +2 more)
Hypercholanemia, familial 1
GUncertain significance
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