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Items: 18

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
NRAS
(P34L)
Single nucleotide variant
(missense variant)
Epidermal nevus
GPathogenic
AKT3
(N229S)
Single nucleotide variant
(missense variant)
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2
+1 more
GPathogenic
PIK3CA
(C420R)
Single nucleotide variant
(missense variant)
Ovarian neoplasm
+7 more
GPathogenic
OOncogenic
PIK3CA
(E542K)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
PIK3CA
(E545K)
Single nucleotide variant
(missense variant)
CLOVES syndrome
+6 more
GPathogenic/Likely pathogenic
OOncogenic
PIK3CA
(H1047L)
Single nucleotide variant
(missense variant)
Inborn genetic diseases
+8 more
GPathogenic
OOncogenic
PIK3CA
(H1047R)
Single nucleotide variant
(missense variant)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
+1 more
GPathogenic
OOncogenic
FGFR3
(R248C)
Single nucleotide variant
(missense variant +1 more)
Connective tissue disorder
+31 more
GPathogenic
FGFR3
(S249C)
Single nucleotide variant
(missense variant +1 more)
Connective tissue disorder
+17 more
GPathogenic
OOncogenic
FGFR3
(G370C +1 more)
Single nucleotide variant
(missense variant +2 more)
Thanatophoric dysplasia type 1
+3 more
GPathogenic
OOncogenic
FGFR3
(G380R +1 more)
Single nucleotide variant
(missense variant +2 more)
Connective tissue disorder
+18 more
GPathogenic/Likely pathogenic
FGFR3
(N540K +3 more)
Single nucleotide variant
(missense variant +1 more)
Connective tissue disorder
+18 more
GPathogenic/Likely pathogenic
FGFR3
(K650T +3 more)
Single nucleotide variant
(missense variant +1 more)
FGFR3-related disorder
+15 more
GPathogenic
FGFR3
(K650M +3 more)
Single nucleotide variant
(missense variant +1 more)
Hypochondroplasia
+14 more
GPathogenic
FGFR3
(V784E)
Single nucleotide variant
(stop lost +2 more)
Achondroplasia
+14 more
GPathogenic
FGFR3
Single nucleotide variant
(stop lost +2 more)
not provided
+14 more
GPathogenic
KRAS
(G12D)
Single nucleotide variant
(missense variant)
Cardiovascular phenotype
+6 more
GPathogenic/Likely pathogenic
OOncogenic
PIK3R2
(G373R)
Single nucleotide variant
(missense variant +1 more)
Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes
GPathogenic
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