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Items: 25

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
MFN2
(L444P)
Single nucleotide variant
(missense variant)
Charcot-Marie-Tooth disease type 2
GUncertain significance
MACF1
(L444P +1 more)
Single nucleotide variant
(missense variant)
not provided
GLikely benign
GBA1, LOC106627981
(L483P +5 more)
Single nucleotide variant
(missense variant +1 more)
Parkinson disease, late-onset
+1 more
GPathogenic
GBA1, LOC106627981
(L483P +2 more)
Single nucleotide variant
(missense variant)
Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome
+14 more
GPathogenic; risk factor
CRB1
(L444P +2 more)
Single nucleotide variant
(missense variant +1 more)
Retinitis pigmentosa
GLikely pathogenic
TTC7A
(L124P +2 more)
Single nucleotide variant
(missense variant)
not provided
+1 more
GConflicting classifications of pathogenicity
CNGA3
(L426P +1 more)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
ADGRG7
(L149P +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
DNAH5
(L444P)
Single nucleotide variant
(missense variant)
Primary ciliary dyskinesia
GUncertain significance
APC
(L447P +12 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+1 more
GUncertain significance
FANCE
(L444P)
Single nucleotide variant
(missense variant)
not specified
+1 more
GUncertain significance
CENPP, ECM2
(L466P +1 more)
Single nucleotide variant
(missense variant +1 more)
not specified
GUncertain significance
SLC46A2
(L444P)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
FRMPD2
(L444P +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
CEP57
(L417P +3 more)
Single nucleotide variant
(missense variant)
Mosaic variegated aneuploidy syndrome 2
GUncertain significance
FOXM1, ITFG2
(L203P +14 more)
Single nucleotide variant
(missense variant +2 more)
not specified
GUncertain significance
SIN3A
(L444P)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
MAPK8IP3
(L444P +2 more)
Single nucleotide variant
(missense variant)
Neurodevelopmental disorder with or without variable brain abnormalities; NEDBA
GLikely pathogenic
TSC2
(L493P +4 more)
Single nucleotide variant
(missense variant)
Tuberous sclerosis 2
GUncertain significance
PKD1
(L444P)
Single nucleotide variant
(missense variant)
Polycystic kidney disease, adult type
GUncertain significance
ACSM2A
(L365P +1 more)
Single nucleotide variant
(missense variant)
not specified
GUncertain significance
BRCA1
(L1610P +77 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary cancer-predisposing syndrome
+1 more
GConflicting classifications of pathogenicity
BRCA1
(L471P +20 more)
Single nucleotide variant
(missense variant +1 more)
Hereditary breast ovarian cancer syndrome
+1 more
GConflicting classifications of pathogenicity
TCF4
(L609P +21 more)
Single nucleotide variant
(missense variant)
Pitt-Hopkins syndrome
GLikely pathogenic
CCDC22
(L444P)
Single nucleotide variant
(missense variant)
not provided
GUncertain significance
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