DKK1[gene] - ClinVar

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Items: 40

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 154900	GRCh38/hg38 10q11.21-21.3(chr10:42112187-67400675)x3	A1CF, ADO +561 more	Copy number gain	See cases	GPathogenic
Select item 145481	GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3	A1CF, ADAMTS14 +902 more	Copy number gain	See cases	GPathogenic
Select item 148945	GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3	LOC129390180, LOC129390181 +1008 more	Copy number gain	See cases	GPathogenic
Select item 148667	GRCh38/hg38 10q11.23-21.1(chr10:50967523-53709183)x1	CSTF2T, DKK1 +18 more	Copy number loss	See cases	GUncertain significance
Select item 1298481	NM_012242.4(DKK1):c.45G>T (p.Ala15=)	DKK1	Single nucleotide variant (synonymous variant)	not provided	GLikely benign
Select item 783572	NM_012242.4(DKK1):c.46A>C (p.Met16Leu)	DKK1 (M16L)	Single nucleotide variant (missense variant)	not provided	GBenign
Select item 756718	NM_012242.4(DKK1):c.111C>T (p.Leu37=)	DKK1	Single nucleotide variant (synonymous variant)	not provided	GLikely benign
Select item 2331419	NM_012242.4(DKK1):c.181A>C (p.Ser61Arg)	DKK1 (S61R)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 3051082	NM_012242.4(DKK1):c.243+9G>A	DKK1	Single nucleotide variant (intron variant)	DKK1-related condition	GLikely benign
Select item 709695	NM_012242.4(DKK1):c.244-6C>T	DKK1	Single nucleotide variant (intron variant)	not provided	GBenign
Select item 2275630	NM_012242.4(DKK1):c.247T>C (p.Tyr83His)	DKK1 (Y83H)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 2360989	NM_012242.4(DKK1):c.292G>C (p.Ala98Pro)	DKK1 (A98P)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 2640477	NM_012242.4(DKK1):c.316G>A (p.Ala106Thr)	DKK1 (A106T)	Single nucleotide variant (missense variant)	not provided	GLikely benign
Select item 2640478	NM_012242.4(DKK1):c.337G>A (p.Ala113Thr)	DKK1 (A113T)	Single nucleotide variant (missense variant)	not provided	GLikely benign
Select item 3037208	NM_012242.4(DKK1):c.359G>T (p.Arg120Leu)	DKK1 (R120L)	Single nucleotide variant (missense variant)	DKK1-related condition	GLikely benign
Select item 3082636	NM_012242.4(DKK1):c.411A>G (p.Ile137Met)	DKK1 (I137M)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 2555246	NM_012242.4(DKK1):c.424G>A (p.Asp142Asn)	DKK1 (D142N)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 3082637	NM_012242.4(DKK1):c.452A>T (p.Glu151Val)	DKK1 (E151V)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 773234	NM_012242.4(DKK1):c.548-4G>A	DKK1	Single nucleotide variant (intron variant)	not provided	GBenign/Likely benign
Select item 2294273	NM_012242.4(DKK1):c.556G>T (p.Gly186Cys)	DKK1 (G186C)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 2481691	NM_012242.4(DKK1):c.634C>T (p.Pro212Ser)	DKK1 (P212S)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 738698	NM_012242.4(DKK1):c.672G>A (p.Arg224=)	DKK1	Single nucleotide variant (synonymous variant)	not provided	GLikely benign
Select item 3082638	NM_012242.4(DKK1):c.685C>T (p.His229Tyr)	DKK1 (H229Y)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 721589	NM_012242.4(DKK1):c.687T>C (p.His229=)	DKK1	Single nucleotide variant (synonymous variant)	not provided	GLikely benign
Select item 3082639	NM_012242.4(DKK1):c.784A>G (p.Thr262Ala)	DKK1 (T262A)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 2685375	GRCh37/hg19 10q11.23-22.1(chr10:51735638-70791246)x1	A1CF, ADO +51 more	Copy number loss	not provided	GPathogenic
Select item 2684602	GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3	RRP12, RTKN2 +332 more	Copy number gain	not provided	GPathogenic
Select item 2574696	GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143)	MTG1, NPS +679 more	Copy number gain	Distal trisomy 10q	GPathogenic
Select item 2574686	GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143)	A1CF, ABCC2 +670 more	Copy number loss	Distal 10q deletion syndrome	GPathogenic
Select item 1527584	GRCh37/hg19 10q11.23-21.1(chr10:52752503-57406199)	CSTF2T, DKK1 +4 more	Copy number gain	not specified	GUncertain significance
Select item 1023392	NC_000010.10:g.(?_54011320)_(54530789_?)dup	DKK1, MBL2 +1 more	Duplication	Aortic aneurysm, familial thoracic 8	GUncertain significance
Select item 815346	GRCh37/hg19 10q21.1(chr10:53802602-55217542)x3	PRKG1, DKK1 +1 more	Copy number gain	not provided	GUncertain significance
Select item 815342	GRCh37/hg19 10q11.23-21.3(chr10:50250603-69256083)x1	TIMM23, C10orf71 +50 more	Copy number loss	not provided	GPathogenic
Select item 686632	GRCh37/hg19 10q21.1(chr10:53815624-54483403)x3	DKK1, PRKG1	Copy number gain	not provided	GUncertain significance
Select item 624468	GRCh37/hg19 10q11.22-21.1(chr10:49390457-60061643)x1	MSMB, MTRNR2L5 +33 more	Copy number loss	not provided	GLikely pathogenic
Select item 523165	GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1	COX15, CPEB3 +569 more	Copy number loss	Poly (ADP-Ribose) polymerase inhibitor response	Gdrug response
Select item 495230	NC_000010.10:g.43611191_61663279inv	CCDC6, ZNF32 +75 more	Inversion	Pediatric metastatic thyroid tumour	GLikely pathogenic
Select item 441987	GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)	A1CF, ABCC2 +721 more	Copy number gain	See cases	GPathogenic
Select item 441986	GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3	A1CF, ABCC2 +721 more	Copy number gain	See cases	GPathogenic
Select item 393995	GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3	BCCIP, BEND7 +722 more	Copy number gain	See cases	GPathogenic

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Items: 40