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Items: 51

Variation
Gene
(Protein Change)
Type
(Consequence)
ConditionClassification, Review status
MUTYH
(E466* +8 more)
Single nucleotide variant
(nonsense +1 more)
Familial adenomatous polyposis 2
+4 more
GConflicting classifications of pathogenicity
FH
Single nucleotide variant
(splice donor variant)
FH-related disorder
+3 more
GPathogenic/Likely pathogenic
FH
Single nucleotide variant
(missense variant)
Fumarase deficiency
+3 more
GPathogenic/Likely pathogenic
MSH2
(K65*)
Single nucleotide variant
(nonsense +1 more)
MSH2-related disorder
+2 more
GPathogenic/Likely pathogenic
MSH6
(R1068* +2 more)
Single nucleotide variant
(nonsense)
Lynch syndrome
GPathogenic
MSH6
(F1088fs +2 more)
Duplication
(frameshift variant)
Lynch syndrome
GPathogenic
MITF
(E318K +9 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+6 more
GPathogenic/Likely pathogenic; risk factor
LOC110011216, PHOX2B
Duplication
(inframe_insertion)
Hereditary cancer-predisposing syndrome
+1 more
GPathogenic
SDHA
(R31*)
Single nucleotide variant
(nonsense)
Paragangliomas 5
+9 more
GPathogenic/Likely pathogenic
SDHA
(F160L +1 more)
Single nucleotide variant
(missense variant)
Paragangliomas 5
+3 more
GConflicting classifications of pathogenicity
SDHA
(E182fs +1 more)
Deletion
(frameshift variant)
not provided
+5 more
GPathogenic/Likely pathogenic
SDHA
(R451S +1 more)
Single nucleotide variant
(missense variant)
Hereditary cancer-predisposing syndrome
+3 more
GConflicting classifications of pathogenicity
SDHA
Single nucleotide variant
(splice acceptor variant)
Mitochondrial complex II deficiency, nuclear type 1
+2 more
GPathogenic/Likely pathogenic
PMS2
(V306E +4 more)
Single nucleotide variant
(missense variant +2 more)
not specified
+4 more
GConflicting classifications of pathogenicity
PMS2
(S46I)
Single nucleotide variant
(missense variant +3 more)
Lynch syndrome
GLikely pathogenic
RET
(K412N +13 more)
Single nucleotide variant
(missense variant)
Hirschsprung disease, susceptibility to, 1
+8 more
GPathogenic/Likely pathogenic
PTEN
(R173H +1 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+4 more
GPathogenic/Likely pathogenic
OOncogenic
ATM
Single nucleotide variant
(splice acceptor variant)
Hereditary cancer-predisposing syndrome
+2 more
GLikely pathogenic
ATM
Single nucleotide variant
(splice donor variant)
Familial cancer of breast
+3 more
GPathogenic/Likely pathogenic
ATM, C11orf65
(R2598*)
Single nucleotide variant
(nonsense +1 more)
Ataxia-telangiectasia syndrome
+4 more
GPathogenic
ATM, C11orf65
(R2993*)
Single nucleotide variant
(nonsense +1 more)
Familial cancer of breast
+5 more
GPathogenic/Likely pathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(E470fs)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(T1251fs)
Duplication
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(Y1655*)
Single nucleotide variant
(nonsense)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(nonsense)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
Deletion
(frameshift variant)
Breast-ovarian cancer, familial, susceptibility to, 2
GPathogenic
BRCA2
(S1982fs)
Deletion
(frameshift variant)
BRCA2-related cancer predisposition
GPathogenic
BRCA2
(C3198fs)
Deletion
(frameshift variant)
not provided
+3 more
GPathogenic/Likely pathogenic
PALB2
Deletion
(frameshift variant)
Familial cancer of breast
+8 more
GPathogenic
TP53
(R119H +2 more)
Single nucleotide variant
(missense variant +1 more)
not provided
+5 more
GPathogenic/Likely pathogenic
FLCN
(R527* +1 more)
Single nucleotide variant
(nonsense)
Birt-Hogg-Dube syndrome
+2 more
GPathogenic/Likely pathogenic
BRCA1
(W1508* +75 more)
Single nucleotide variant
(nonsense +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(C856fs +20 more)
Duplication
(intron variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(K812fs +20 more)
Deletion
(frameshift variant +1 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
BRCA1
(K739* +20 more)
Duplication
(frameshift variant +2 more)
Breast-ovarian cancer, familial, susceptibility to, 1
GPathogenic
HOXB13
(G84E)
Single nucleotide variant
(missense variant)
Prostate cancer, hereditary, 9
+7 more
GPathogenic/Likely pathogenic; association
BRIP1
Deletion
(frameshift variant)
not provided
+6 more
GPathogenic/Likely pathogenic
BRIP1
(S624*)
Single nucleotide variant
(nonsense)
not provided
+7 more
GPathogenic
BRIP1
(Q414*)
Single nucleotide variant
(nonsense)
Ovarian neoplasm
+5 more
GPathogenic/Likely pathogenic
BRIP1
(E412fs)
Deletion
(frameshift variant)
Familial cancer of breast
+4 more
GPathogenic/Likely pathogenic
BRIP1
Deletion
(frameshift variant)
Familial cancer of breast
+3 more
GPathogenic/Likely pathogenic
LZTR1
Single nucleotide variant
(splice donor variant)
not provided
+4 more
GPathogenic/Likely pathogenic
LZTR1
Single nucleotide variant
(splice acceptor variant)
not provided
+3 more
GLikely pathogenic
LZTR1
(R284C)
Single nucleotide variant
(missense variant)
Noonan syndrome 10
+4 more
GPathogenic
LZTR1
Single nucleotide variant
(intron variant)
Schwannomatosis 2
+5 more
GConflicting classifications of pathogenicity
CHEK2
(T146fs +4 more)
Deletion
(frameshift variant)
Bone osteosarcoma
+21 more
GPathogenic
CHEK2
Single nucleotide variant
(splice donor variant)
Bone osteosarcoma
+12 more
GPathogenic/Likely pathogenic
CHEK2
(W93*)
Single nucleotide variant
(nonsense +1 more)
Hereditary breast ovarian cancer syndrome
+5 more
GPathogenic/Likely pathogenic
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