"Color Diagnostics, LLC DBA Color Health"[submitter] AND "MSH6"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 924812	NM_000179.3(MSH6):c.-20G>C	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 491859	NM_000179.3(MSH6):c.-20G>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 378159	NM_000179.3(MSH6):c.-19G>C	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 89159	NM_000179.3(MSH6):c.-18G>T	MSH6	Single nucleotide variant (5 prime UTR variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 491858	NM_000179.3(MSH6):c.-17C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	not specified +1 more	GLikely benign
Select item 491857	NM_000179.3(MSH6):c.-16C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 420296	NM_000179.3(MSH6):c.-16C>A	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 378160	NM_000179.3(MSH6):c.-14T>C	MSH6	Single nucleotide variant (5 prime UTR variant)	Lynch syndrome +2 more	GLikely benign
Select item 1331929	NM_000179.3(MSH6):c.-13G>C	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 925306	NM_000179.3(MSH6):c.-13G>A	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 920116	NM_000179.3(MSH6):c.-12C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 381231	NM_000179.3(MSH6):c.-12C>G	MSH6	Single nucleotide variant (5 prime UTR variant)	Lynch syndrome +2 more	GConflicting classifications of pathogenicity
Select item 2773624	NM_000179.3(MSH6):c.-11C>G	MSH6	Single nucleotide variant (non-coding transcript variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 491856	NM_000179.3(MSH6):c.-11C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 628020	NM_000179.3(MSH6):c.-9G>A	MSH6	Single nucleotide variant (5 prime UTR variant)	not specified +1 more	GUncertain significance
Select item 89164	NM_000179.3(MSH6):c.-8C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Lynch syndrome 5 +5 more	GConflicting classifications of pathogenicity
Select item 388545	NM_000179.3(MSH6):c.-7T>A	MSH6	Single nucleotide variant (5 prime UTR variant)	not specified +1 more	GConflicting classifications of pathogenicity
Select item 630667	NM_000179.3(MSH6):c.-6G>A	MSH6	Single nucleotide variant (5 prime UTR variant)	not provided +1 more	GUncertain significance
Select item 371918	NM_000179.3(MSH6):c.-6G>C	MSH6	Single nucleotide variant (5 prime UTR variant)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 182674	NM_000179.3(MSH6):c.-6G>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +4 more	GBenign/Likely benign
Select item 628371	NM_000179.3(MSH6):c.-4C>G	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 491860	NM_000179.3(MSH6):c.-4C>T	MSH6	Single nucleotide variant (5 prime UTR variant)	Lynch syndrome +1 more	GConflicting classifications of pathogenicity
Select item 920731	NM_000179.3(MSH6):c.-3G>A	MSH6	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 142219	NM_000179.3(MSH6):c.-2G>T	MSH6	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 386038	NM_000179.3(MSH6):c.-1T>C	MSH6	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 455339	NM_000179.3(MSH6):c.6G>A (p.Ser2=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 862542	NM_000179.3(MSH6):c.8G>A (p.Arg3Gln)	MSH6 (R3Q)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 183723	NM_000179.3(MSH6):c.10C>T (p.Gln4Ter)	MSH6 (Q4*)	Single nucleotide variant (nonsense +1 more)	Lynch syndrome +8 more	GPathogenic/Likely pathogenic
Select item 630936	NM_000179.3(MSH6):c.12G>A (p.Gln4=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 485852	NM_000179.3(MSH6):c.14G>A (p.Ser5Asn)	MSH6 (S5N)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 428380	NM_000179.3(MSH6):c.16A>C (p.Thr6Pro)	MSH6 (T6P)	Single nucleotide variant (missense variant +1 more)	Endometrial carcinoma +5 more	GConflicting classifications of pathogenicity
Select item 924072	NM_000179.3(MSH6):c.18C>G (p.Thr6=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome +2 more	GLikely benign
Select item 455159	NM_000179.3(MSH6):c.18C>T (p.Thr6=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome +2 more	GLikely benign
Select item 421374	NM_000179.3(MSH6):c.19C>A (p.Leu7Met)	MSH6 (L7M)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +5 more	GUncertain significance
Select item 2773625	NM_000179.3(MSH6):c.21G>A (p.Leu7=)	MSH6	Single nucleotide variant (5 prime UTR variant +3 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 483856	NM_000179.3(MSH6):c.21G>T (p.Leu7=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GLikely benign
Select item 491893	NM_000179.3(MSH6):c.22T>A (p.Tyr8Asn)	MSH6 (Y8N)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 141874	NM_000179.3(MSH6):c.25A>G (p.Ser9Gly)	MSH6 (S9G)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +4 more	GConflicting classifications of pathogenicity
Select item 628563	NM_000179.3(MSH6):c.30C>A (p.Phe10Leu)	MSH6 (F10L)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 185320	NM_000179.3(MSH6):c.30C>T (p.Phe10=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 630498	NM_000179.3(MSH6):c.33C>T (p.Phe11=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 186416	NM_000179.3(MSH6):c.33C>G (p.Phe11Leu)	MSH6 (F11L)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +4 more	GConflicting classifications of pathogenicity
Select item 141885	NM_000179.3(MSH6):c.34C>A (p.Pro12Thr)	MSH6 (P12T)	Single nucleotide variant (missense variant +1 more)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 919074	NM_000179.3(MSH6):c.35C>G (p.Pro12Arg)	MSH6 (P12R)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 479906	NM_000179.3(MSH6):c.36C>G (p.Pro12=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GLikely benign
Select item 920371	NM_000179.3(MSH6):c.37A>C (p.Lys13Gln)	MSH6 (K13Q)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +3 more	GUncertain significance
Select item 410440	NM_000179.3(MSH6):c.37A>G (p.Lys13Glu)	MSH6 (K13E)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 410465	NM_000179.3(MSH6):c.38A>G (p.Lys13Arg)	MSH6 (K13R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 36596	NM_000179.3(MSH6):c.38A>C (p.Lys13Thr)	MSH6 (K13T)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 5 +6 more	GUncertain significance
Select item 233451	NM_000179.3(MSH6):c.40T>G (p.Ser14Ala)	MSH6 (S14A)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 216318	NM_000179.3(MSH6):c.41C>T (p.Ser14Phe)	MSH6 (S14F)	Single nucleotide variant (missense variant +1 more)	not provided +6 more	GConflicting classifications of pathogenicity
Select item 483882	NM_000179.3(MSH6):c.43C>G (p.Pro15Ala)	MSH6 (P15A)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 184992	NM_000179.3(MSH6):c.43C>T (p.Pro15Ser)	MSH6 (P15S)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 1194436	NM_000179.3(MSH6):c.45G>C (p.Pro15=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not provided +2 more	GLikely benign
Select item 825033	NM_000179.3(MSH6):c.45G>A (p.Pro15=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 491976	NM_000179.3(MSH6):c.48G>C (p.Ala16=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 490023	NM_000179.3(MSH6):c.52A>C (p.Ser18Arg)	MSH6 (S18R)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 455333	NM_000179.3(MSH6):c.58dup (p.Ala20fs)	MSH6 (A20fs)	Duplication (frameshift variant +1 more)	Endometrial carcinoma +3 more	GPathogenic/Likely pathogenic
Select item 387635	NM_000179.3(MSH6):c.57T>C (p.Asp19=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GLikely benign
Select item 89540	NM_000179.3(MSH6):c.59C>T (p.Ala20Val)	MSH6 (A20V)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 1	GLikely benign
Select item 920001	NM_000179.3(MSH6):c.60C>A (p.Ala20=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 483849	NM_000179.3(MSH6):c.60C>G (p.Ala20=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 237211	NM_000179.3(MSH6):c.60C>T (p.Ala20=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 485853	NM_000179.3(MSH6):c.61A>G (p.Asn21Asp)	MSH6 (N21D)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome 5 +3 more	GConflicting classifications of pathogenicity
Select item 919809	NM_000179.3(MSH6):c.63C>T (p.Asn21=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GLikely benign
Select item 410429	NM_000179.3(MSH6):c.64A>G (p.Lys22Glu)	MSH6 (K22E)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +3 more	GUncertain significance
Select item 419112	NM_000179.3(MSH6):c.67G>C (p.Ala23Pro)	MSH6 (A23P)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 182652	NM_000179.3(MSH6):c.67G>A (p.Ala23Thr)	MSH6 (A23T)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GUncertain significance
Select item 573095	NM_000179.3(MSH6):c.68C>T (p.Ala23Val)	MSH6 (A23V)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 384920	NM_000179.3(MSH6):c.69C>G (p.Ala23=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GLikely benign
Select item 184777	NM_000179.3(MSH6):c.71C>T (p.Ser24Leu)	MSH6 (S24L)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +3 more	GUncertain significance
Select item 89562	NM_000179.3(MSH6):c.73G>T (p.Ala25Ser)	MSH6 (A25S)	Single nucleotide variant (missense variant +1 more)	not provided +9 more	GConflicting classifications of pathogenicity
Select item 925753	NM_000179.3(MSH6):c.74C>G (p.Ala25Gly)	MSH6 (A25G)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 182675	NM_000179.3(MSH6):c.74C>T (p.Ala25Val)	MSH6 (A25V)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 483761	NM_000179.3(MSH6):c.75C>T (p.Ala25=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 920304	NM_000179.3(MSH6):c.78G>T (p.Arg26Ser)	MSH6 (R26S)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 455346	NM_000179.3(MSH6):c.78G>A (p.Arg26=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GLikely benign
Select item 919128	NM_000179.3(MSH6):c.80_83del (p.Ala27fs)	MSH6 (A27fs)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 185732	NM_000179.3(MSH6):c.81C>G (p.Ala27=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome +5 more	GBenign/Likely benign
Select item 455351	NM_000179.3(MSH6):c.83C>T (p.Ser28Leu)	MSH6 (S28L)	Single nucleotide variant (missense variant +1 more)	not provided +3 more	GConflicting classifications of pathogenicity
Select item 525700	NM_000179.3(MSH6):c.85C>G (p.Arg29Gly)	MSH6 (R29G)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 485850	NM_000179.3(MSH6):c.85C>T (p.Arg29Cys)	MSH6 (R29C)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 230422	NM_000179.3(MSH6):c.87C>G (p.Arg29=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Lynch syndrome 5 +4 more	GBenign/Likely benign
Select item 483760	NM_000179.3(MSH6):c.88G>C (p.Glu30Gln)	MSH6 (E30Q)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 455356	NM_000179.3(MSH6):c.88G>A (p.Glu30Lys)	MSH6 (E30K)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 382003	NM_000179.3(MSH6):c.93C>T (p.Gly31=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not provided +3 more	GLikely benign
Select item 216325	NM_000179.3(MSH6):c.94G>T (p.Gly32Cys)	MSH6 (G32C)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +6 more	GConflicting classifications of pathogenicity
Select item 418608	NM_000179.3(MSH6):c.95G>A (p.Gly32Asp)	MSH6 (G32D)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GConflicting classifications of pathogenicity
Select item 491997	NM_000179.3(MSH6):c.97C>A (p.Arg33Ser)	MSH6 (R33S)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +2 more	GUncertain significance
Select item 573535	NM_000179.3(MSH6):c.98G>T (p.Arg33Leu)	MSH6 (R33L)	Single nucleotide variant (missense variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GUncertain significance
Select item 237219	NM_000179.3(MSH6):c.98G>C (p.Arg33Pro)	MSH6 (R33P)	Single nucleotide variant (missense variant +1 more)	Lynch syndrome +5 more	GUncertain significance
Select item 449945	NM_000179.3(MSH6):c.100G>A (p.Ala34Thr)	MSH6 (A34T)	Single nucleotide variant (missense variant +1 more)	not provided +2 more	GUncertain significance
Select item 491861	NM_000179.3(MSH6):c.101C>G (p.Ala34Gly)	MSH6 (A34G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 455105	NM_000179.3(MSH6):c.102C>T (p.Ala34=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GBenign/Likely benign
Select item 183756	NM_000179.3(MSH6):c.102C>A (p.Ala34=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +4 more	GBenign/Likely benign
Select item 410435	NM_000179.3(MSH6):c.104C>T (p.Ala35Val)	MSH6 (A35V)	Single nucleotide variant (missense variant +1 more)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 631354	NM_000179.3(MSH6):c.105C>G (p.Ala35=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	Hereditary nonpolyposis colorectal neoplasms +1 more	GLikely benign
Select item 439198	NM_000179.3(MSH6):c.105C>T (p.Ala35=)	MSH6	Single nucleotide variant (synonymous variant +1 more)	not specified +2 more	GConflicting classifications of pathogenicity
Select item 140779	NM_000179.3(MSH6):c.107C>T (p.Ala36Val)	MSH6 (A36V)	Single nucleotide variant (missense variant +1 more)	Breast and/or ovarian cancer +8 more	GConflicting classifications of pathogenicity
Select item 628894	NM_000179.3(MSH6):c.114del (p.Ala40fs)	MSH6 (A40fs)	Deletion (frameshift variant +1 more)	Lynch syndrome 5 +1 more	GPathogenic

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