1PN3,1PNV,1PNV,1RRV,1RRV,2ACV,2C1X,2IYA,2P6P,2PQ6,2VCE,4AMB,3RSC,5DU2,4FZR,3D0R,3UYK,4RIH,5TMB,3WC4,3HBF,5V2K


Conserved Protein Domain Family
GT1_Gtf-like

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cd03784: GT1_Gtf-like 
Click on image for an interactive view with Cn3D
UDP-glycosyltransferases and similar proteins
This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.
Statistics
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PSSM-Id: 340817
Aligned: 399 rows
Threshold Bit Score: 105.711
Created: 8-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1PN3: Amycolatopsis orientalis TDP-epi-vancosaminyltransferase GtfA binds desvancosaminyl vancomycin (DVV) and TDP. Contacts at 3.5A.
  • Structure:1RRV: Amycolatopsis orentalis TDP-epi-vancosaminyltransferase GtfD binds vancomycin and TDP. Contacts at 3.5A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       ## #                                                          
1PN3_A      1 MRVLITGcg-------srGDTEPLVALAARLr-eLGADARMCLpp----------------dyVERCAEVGVPMVPVgra 56  Amycolatopsis orie...
Q2V6J9     11 LHIFFLPfm-------arGHSIPLTDIAKLFs-sHGARCTIVTtpln------------aplfSKATQRGEIELVLIkfp 70  strawberry
Q8H0F2      4 LHVFFFPfl-------anGHILPTIDMAKLFs-sRGVKATLITthnnsai-------flkainRSKILGFDISVLTIkfp 68  Gentiana triflora
NP_181215  13 LHFILFPfm-------aqGHMIPMIDIARLLa-qRGATVTIVTtrynag---------rfenvLSRAMESGLPINIVhvn 75  thale cress
D4Q9Z4      8 LKSIFLPfl-------stSHIIPLVDMARLFa-lHDVDVTIITtahnatvfq---ksidldasRGRPIRTHVVNFPAaqv 76  soybean
Q9SCP6     12 LHFVLIPlm-------aqGHLIPMVDISKILa-rQGNIVTIVTtpqnas--------rfaktvDRARLESGLEINVVkfp 75  thale cress
Q8W3P8      1 MKTLTPSveifffpyvggGHQIPMIDAARMFa-sHGASSTILAtpst------------tplfQKCITRDQKFGLPIsih 67  adzuki bean
NP_181214  13 LHFVLFPfm-------aqGHMIPMVDIARILa-qRGVTITIVTtphnaarfkdvlnraiqsglHIRVEHVKFPFQEAglq 84  thale cress
NP_190884   7 LHFVVIPfm-------aqGHMIPLVDISRLLsqrQGVTVCIITtt-----------------qNVAKIKTSLSFSSLfat 62  thale cress
NP_181213   9 LHFVLFPfm-------aqGHMIPMVDIARLLa-qRGVTITIVTtpqnag---------rfknvLSRAIQSGLPINLVqvk 71  thale cress
Feature 1                                                                                     
1PN3_A     57 vragarep------------gelppgaaevvTEVVAEWFDKVPaai--------------------egCDAVVTTgllpA 104 Amycolatopsis orie...
Q2V6J9     71 saeagl----------------pqdcesadlITTQDMLGKFVKatfliephf--------ekildehrPHCLVADa---F 123 strawberry
Q8H0F2     69 saefglpe------------gyetadqarsiDMMDEFFRACILlqeplee------------llkehrPQALVADl---F 121 Gentiana triflora
NP_181215  76 fpyqefglpegkenidsydsmelmvpffqavNMLEDPVMKLMEemk--------------------prPSCIISDl---L 132 thale cress
D4Q9Z4     77 glpvgieaf----------nvdtpremtpriYMGLSLLQQVFEklfh------------------dlqPDFIVTDm---F 125 soybean
Q9SCP6     76 ipykefglpkdce---tldtlpskdllrrfyDAVDKLQEPMERfleq-----------------qdipPSCIISDk---C 132 thale cress
Q8W3P8     68 tl-------------------------sadvPQSDISVGPFLDtsallepl---------rqlllqrrPHCIVVDm--fH 111 adzuki bean
NP_181214  85 -----------------------------egQENVDFLDSMELmvhffkavnmlenpvmklmeemkpkPSCLISDf--cL 133 thale cress
NP_190884  63 inivevkfl----------sqqtglpegcesLDMLASMGDMVKffdaansleeqv--ekameemvqprPSCIIGDm--sL 128 thale cress
NP_181213  72 fpsq--------------------esgspegQENLDLLDSLGAsltffkafslleepvekllkeiqprPNCIIADm--cL 129 thale cress
Feature 1                                                                                     
1PN3_A    105 AVAVRSMAEkl---------------giPYRYTVLSPdhlpseq------------------------------------ 133 Amycolatopsis orie...
Q2V6J9    124 FTWATDVAAkfriprly---fhgtgffaLCASLSVMMyqphsnlssdsesfvip-------------------------n 175 strawberry
Q8H0F2    122 FYWANDAAAkf---------------giPRLLFHGSSsfamiaaesvrr------------------------------- 155 Gentiana triflora
NP_181215 133 LPYTSKIARkf---------------siPKIVFHGTGcfnllcmhvlrrnleilknlksdk-----------dyflvpsf 186 thale cress
D4Q9Z4    126 HPWSVDAAAkl---------------giPRIMFHGASylarsaahsveqyaphleakfdtd------------kfvlpgl 178 soybean
Q9SCP6    133 LFWTSRTAKrfkiprivfhgmccfsllsSHNIHLHSPhlsv--------------------------------------- 173 thale cress
Q8W3P8    112 RWSGDVVYEl-----------------gIPRTLFNGIgcfa--------------------------------------- 135 adzuki bean
NP_181214 134 PYTSKIAKRfn----------------iPKIVFHGVScfcllsmhilhrnhnilhalksdk-----------eyflvpsf 186 thale cress
NP_190884 129 PFTSRLAKKfk----------------iPKLIFHGFScfslmsiqvvresgilkmiesndeyfdlpglpdkveftkpqvs 192 thale cress
NP_181213 130 PYTNRIAKNlg----------------iPKIIFHGMCcfnllcthimhqnhefleties----------------dkeyf 177 thale cress
Feature 1                     #  ##   #                                                       
1PN3_A    134 ---------sqaerdmYNQGADRLFGDAVNSHRASIglppve-------------------------------------- 166 Amycolatopsis orie...
Q2V6J9    176 lpdeikmtrsqlpvfpDESEFMKMLKASIEIEERSYgvivnsfyelep---------------------------ayanh 228 strawberry
Q8H0F2    156 -----nkpyknlssdsDPFVVPDIPDKIILTKSQVPtpdeteennthitemwknisesendcygvivnsfyelepdyvdy 230 Gentiana triflora
NP_181215 187 pdrveftkpqvpvettASGDWKAFLDEMVEAEYTSYgvivntfqele-----------------------------payv 237 thale cress
D4Q9Z4    179 pdnlemtrlqlpdwlrSPNQYTELMRTIKQSEKKSYgslfnsfydles---------------------------ayyeh 231 soybean
Q9SCP6    174 ------------ssavEPFPIPGMPHRIEIARAQLPgafeklanmdd-----------------------------vrek 212 thale cress
Q8W3P8    136 -------------lcvQENLRHVAFKSVSTDSEPFLvpnipdri----------------------------------em 168 adzuki bean
NP_181214 187 pdrveftklqvtvktnFSGDWKEIMDEQVDADDTSYgvivntfqdle-----------------------------sayv 237 thale cress
NP_190884 193 vlqpvegnmkestakiIEADNDSYGVIVNTFEELEVdyarey-------------------------------------- 234 thale cress
NP_181213 178 pipnfpdrveftksqlPMVLVAGDWKDFLDGMTEGDn------------------------------------------- 214 thale cress
Feature 1           #                                                                         
1PN3_A    167 hlydygYTDQPWLAADPvlsplrptdlgtvq---------------------------------------tgawilpder 207 Amycolatopsis orie...
Q2V6J9    229 yrkvfgRKAWHIGPVSFcnkaiedkaer---------------------------------------------gsiksst 263 strawberry
Q8H0F2    231 cknvlgRRAWHIGPLSLcnnegedvae-----------------------------------------------rgkksd 263 Gentiana triflora
NP_181215 238 kdytkaRAGKVWSIGPVslcnkagadka---------------------------------------------ergnqaa 272 thale cress
D4Q9Z4    232 yksimgTKSWGIGPVSLwanqdaqdk------------------------------------------------aargya 263 soybean
Q9SCP6    213 mresesEAFGVIVNSFQelepgyaeayaeainkkvwfvgpv-------------------slcndrmadlfdrgsngnia 273 thale cress
Q8W3P8    169 tmsqlpPFLRNPSGIPErwrgmkqleeksfgtlinsfydlepayadlikskwgnkawivgpvsfcnrskedktergkppt 248 adzuki bean
NP_181214 238 knyteaRAGKVWSIGPVslcnkvgedka---------------------------------------------ergnkaa 272 thale cress
NP_190884 235 -rkaraGKVWCVGPVSLcnrlgldkak-----------------------------------------------rgdkas 266 thale cress
NP_181213 215 ------TSYGVIVNTFEelepayvrdykkvkagkiwsigp---------------------vslcnklgedqaergnkad 267 thale cress
Feature 1                                #                                                    
1PN3_A    208 plsAELEAFLAa-----gSTPVYVGFGSssr------------------------patADAAKMAIKAVRas-------- 250 Amycolatopsis orie...
Q2V6J9    264 aekHECLKWLDsk---kpRSVVYVSFGSmvr-------------------------faDSQLLEIATGLEas-------- 307 strawberry
Q8H0F2    264 idaHECLNWLDsk---npDSVVYVCFGSman------------------------fnaAQLHELAMGLEEsg-------- 308 Gentiana triflora
NP_181215 273 idqDECLQWLDsk---edGSVLYVCLGSicnlplsq--------------lkelglglEKSQRSFIWVIRgwekynelye 335 thale cress
D4Q9Z4    264 keeEEKEGWLKwlnskaeSSVLYVSFGSink-------------------------fpYSQLVEIARALEds-------- 310 soybean
Q9SCP6    274 iseTECLQFLDsm---rpRSVLYVSLGSlcr------------------------lipNQLIELGLGLEEsgkpfiw--- 323 thale cress
Q8W3P8    249 ideQNCLNWLNsk---kpSSVLYASFGSlar------------------------lppEQLKEIAYGLEAse-------- 293 adzuki bean
NP_181214 273 idqDECIKWLDsk---dvESVLYVCLGSicn------------------------lplAQLRELGLGLEAtk-------- 317 thale cress
NP_190884 267 igqDQCLQWLDsq---etGSVLYVCLGSlcn------------------------lplAQLKELGLGLEAsn-------- 311 thale cress
NP_181213 268 idqDECIKWLDsk---eeGSVLYVCLGSicnlplsqlkelglgleesqrpfiwvirgwEKYNELLEWISEsg-------- 336 thale cress
Feature 1                                                                            # # ##  #
1PN3_A    251 ------grRIVLSRGwadlvl--------------------pddgadCFVVge-vNLQELFGr--VAAAIHHDSaGTTLL 301 Amycolatopsis orie...
Q2V6J9    308 ------gqDFIWVVKkekkeveewlp----------egfekrmegkgLIIRdw-aPQVLILEheaIGAFVTHCGwNSILE 370 strawberry
Q8H0F2    309 -------qEFIWVVRtcvdeedeskwfp------dgfekrvqennkgLIIKgw-aPQVLILEheaVGAFVSHCGwNSTLE 374 Gentiana triflora
NP_181215 336 wmmesgfeERIKERG--------------------------------LLIKgw-sPQVLILShpsVGGFLTHCGwNSTLE 382 thale cress
D4Q9Z4    311 ------ghDFIWVVRkndggegdnfle---------efekrmkesnkGYLIwgwaPQLLILEnpaIGGLVTHCGwNTVVE 375 soybean
Q9SCP6    324 -vikteekHMIELDEwlkrenf------------------eervrgrGIVIkgwsPQAMILShgsTGGFLTHCGwNSTIE 384 thale cress
Q8W3P8    294 -------qSFIWVVGnilhnpsenkengsgnwlpegfeqrmketgkgLVLRgw-aPQLLILEhaaIKGFMTHCGwNSTLE 365 adzuki bean
NP_181214 318 -------rPFIWVIRgggkyhelaewil-------esgfeertkersLLIKgw-sPQMLILShpaVGGFLTHCGwNSTLE 382 thale cress
NP_190884 312 -------kPFIWVIRewgkygdlanwm--------qqsgfeerikdrGLVIkgwaPQVFILShasIGGFLTHCGwNSTLE 376 thale cress
NP_181213 337 ------ykERIKERG--------------------------------LLITgw-sPQMLILThpaVGGFLTHCGwNSTLE 377 thale cress
Feature 1                                                                                     
1PN3_A    302 AMRaGIPQIVVRrvvdnvveqayhADRVAELGVGVAVDgpv-------------ptiDSLSAALDTALA----------- 357 Amycolatopsis orie...
Q2V6J9    371 AVSaGVPMITWPvfgeqf-yneklVTEIHRIGVPVGSEkwalsfvdvnaetegrvrrEAIEEAVTRIMVgdeavetrsrv 449 strawberry
Q8H0F2    375 GICgGVAMVTWPlfaeq---fyneKLMTDILRTGVSVGslqwsrvt---tsavvvkrESISKAVRRLMA----------- 437 Gentiana triflora
NP_181215 383 GITsGIPLITWPlfgdq---fcnqKLVVQVLKAGVSAGveevmkwgeeekigvlvdkEGVKKAVEELMGa---------- 449 thale cress
D4Q9Z4    376 SVNaGLPMATWPlfaeh---ffneKLVVDVLKIGVPVGakewrnwne--fgsevvkrEEIGNAIASLMSeee-------- 442 soybean
Q9SCP6    385 AICfGVPMITWPlfaeq---flneKLIVEVLNIGVRVGveipvrwgdeerlgvlvkkPSVVKAIKLLMDqdcqrv---de 458 thale cress
Q8W3P8    366 GVSaGVPMITWPltaeq---fsneKLITEVLKTGVQVGnrewwpwna--ewkglvgrEKVEVAVRKLMVesv-------- 432 adzuki bean
NP_181214 383 GITsGVPLITWPlfgdq---fcnqKLIVQVLKAGVSVGveevmkwgeeesigvlvdkEGVKKAVDEIMGe---------- 449 thale cress
NP_190884 377 GITaGVPLLTWPlfaeq---flneKLVVQILKAGLKIGveklmkygkeeeigamvsrECVRKAVDELMGdse-------- 445 thale cress
NP_181213 378 GITsGVPLLTWPlfgdq---fcneKLAVQILKAGVRAGveesmrwgeeekigvlvdkEGVKKAVEELMGdsn-------- 446 thale cress
Feature 1                                            
1PN3_A    358 ---PEIRARATTvadt-------iradGTTVAAQLLFDA 386 Amycolatopsis orientalis
Q2V6J9    450 kelGENARRAVEe-------------gGSSFLDLSALVG 475 strawberry
Q8H0F2    438 ---EEEGVDIRNrakalkekakkavegGGSSYSDLSALL 473 Gentiana triflora
NP_181215 450 --sDDAKERRRRvk------------eLGESAHKAVEEG 474 thale cress
D4Q9Z4    443 -edGGMRKRAKEls------------vAAKSAIKVGGSS 468 soybean
Q9SCP6    459 nddDNEFVRRRRriq----------elAVMAKKAVEEKG 487 thale cress
Q8W3P8    433 -eaDEMRRRAKDiagkaa----raveeGGTSYADVEALI 466 adzuki bean
NP_181214 450 --sDEAKERRKRvr------------eLGELAHKAVEEG 474 thale cress
NP_190884 446 -eaEERRRKVTElsdlank-alekggsSDSNITLLIQDI 482 thale cress
NP_181213 447 -daKERRKRVKE---------------LGELAHKAVEEG 469 thale cress

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