4II2


Conserved Protein Domain Family
Ube1

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TIGR01408: Ube1 
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ubiquitin-activating enzyme E1
This model represents the full length, over a thousand amino acids, of a multicopy family of eukaryotic proteins, many of which are designated ubiquitin-activating enzyme E1. Members have two copies of the ThiF family domain (pfam00899), a repeat found in ubiquitin-activating proteins (pfam02134), and other regions.
Statistics
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PSSM-Id: 273603
Aligned: 3 rows
Threshold Bit Score: 1810.25
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4II2_A      3 TIDEGLYSRQLYVLGHEAMKQMSQSNVLIIGCKGLGVEIAKNVCLAGVKSVTLYDPQPTRIEDLSSQYFLTEDDIG--VP 80   Schizosaccharomyc...
BAB19785   38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVnkRN 117  human
AAB39246   72 EIDEDLHSRQLAVYGRETMRRLFASNVLISGMHGLGAEIAKNLILAGVKSVTLHDERVVELWDLSSNFVFSEDDVG--KN 149  thale cress
4II2_A     81 RAKVTVSKLAELNQYVPVSVVDELS-TE----YLKNFKCVVVTETSLTKQLEINDFTHKNH--IAYIAADSRGLFGSIFC 153  Schizosaccharomyc...
BAB19785  118 RAEAVLKHIAELNPYVHVTSSSVPFnETtdlsFLDKYQCVVLTEMKLPLQKKINDFCRSQCppIKFISADVHGIWSRLFC 197  human
AAB39246  150 RADASVQKLQDLNNAVVVSSLTKSLnKE----DLSGFQVVVFSDISMERAIEFDDYCHSHQppIAFVKADVRGLFGSVFC 225  thale cress
4II2_A    154 DFGENFICTDTDGNEPLTGMIASITDD--GVVTMLEETRHGLENGDFVKFTEVKGMPGLNDgTPRKVEVKGPYTFSIGSV 231  Schizosaccharomyc...
BAB19785  198 DFGDEFEVLDTTGEEPKEIFISNITQAnpGIVTCLENHPHKLETGQFLTFREINGMTGLNG-SIQQITVISPFSFSIGDT 276  human
AAB39246  226 DFGPEFAVLDVDGEEPHTGIIASISNEnqAFISCVDDERLEFEDGDLVVFSEVEGMTELNDgKPRKIKSTRPYSFTLDED 305  thale cress
4II2_A    232 KD-LGSAGYNGVFTQVKVPTKISFKSLRESLKDP-EYVYPDFGKMMRPPQYHIAFQALSAFADAHEgSLPRPRNDIDAAE 309  Schizosaccharomyc...
BAB19785  277 TE-LEPYLHGGIAVQVKTPKTVFFESLERQLKHP-KCLIVDFSNPEAPLEIHTAMLALDQFQEKYS-RKPNVGCQQDSEE 353  human
AAB39246  306 TTnYGTYVKGGIVTQVKQPKLLNFKPLREALKDPgDFLFSDFSKFDRPPLLHLAFQALDHFKAEAG-RFPVAGSEEDAQK 384  thale cress
4II2_A    310 FFEFCKKIAS--TLQFdVELDEKLIKEISYQARGDLVAMSAFLGGAVAQEVLKATTSKFYPLKQYFYFDSLESLPSSvti 387  Schizosaccharomyc...
BAB19785  354 LLKLATSISEt-LEEK-PDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLg-- 429  human
AAB39246  385 LISIATAINTgqGDLKvENVDQKLLRHFSFGAKAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQFFYFDSVESLPSE--- 461  thale cress
4II2_A    388 S--EETCKPRGCRYDGQIAVFGSEFQEKIASLSTFLVGAGAIGCEMLKNWAMMGVATGE-SGHISVTDMDSIEKSNLNRQ 464  Schizosaccharomyc...
BAB19785  430 KpeCEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKeKGMITVTDPDLIEKSNLNRQ 509  human
AAB39246  462 PvdSSDFAPRNSRYDAQISVFGAKFQKKLEDAKVFTVGSGALGCEFLKNLALMGVSCGS-QGKLTVTDDDIIEKSNLSRQ 540  thale cress
4II2_A    465 FLFRPRDVGKLKSECASTAVSIMNPSLTgkITSYQERVGPESEGIFGDEFFEKLSLVTNALDNVEARMYVDRRCVFFEKP 544  Schizosaccharomyc...
BAB19785  510 FLFRPHHIQKPKSYTAADATLKINSQIK--IDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRP 587  human
AAB39246  541 FLFRDWNIGQAKSTVAASAAAVINPRFN--IEALQNRVGAETENVFDDAFWENLTVVVNALDNVNARLYVDSRCLYFQKP 618  thale cress
4II2_A    545 LLESGTLGTKGNTQVVVPHLTESYGSSQDPPEKSFPICTLKNFPNRIEHTIAWARDLFEGLFKQPIDNVNMYLSSPN-FL 623  Schizosaccharomyc...
BAB19785  588 LLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSsAE 667  human
AAB39246  619 LLESGTLGTKCNTQSVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSSPVeYT 698  thale cress
4II2_A    624 ETSLKT-SSNPREVLENIRDYLVtEKPLSFEECIMWARLQFDKFFNNNIQQLLFNFPKDSVTSTGQPFWSGPKRAPTPLS 702  Schizosaccharomyc...
BAB19785  668 EVLQKIqSGHSLEGCFQVIKLLS-RRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPIK 746  human
AAB39246  699 NSMMSAgDAQARDTLERIVECLEkEKCETFQDCLTWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSAPKRFPRPLQ 778  thale cress
4II2_A    703 FDIHNREHFDFIVAAASLYAFNYGLKS-ETDP---AIYeRVLAGYNPPPFAPkSGIKIQVNENEEAPETAAn---KDKQE 775  Schizosaccharomyc...
BAB19785  747 FDLNEPLHLSFLQNAAKLYATVYCIPFaEEDLs-aDALlNILSEVKIQEFKP-SNKVVQTDETARKPDHVPisseDERNA 824  human
AAB39246  779 YSSSDPSLLNFITATAILRAETFGIPIpEWTKnpkEAA-EAVDRVIVPDFEPrQDAKIVTDEKATTLTTASv---DDAAV 854  thale cress
4II2_A    776 LKSIADSLPPPSSLVG--FRLTPAEFEKDDDSNHHIDFITAASNLRAMNYDITPADRFKTKFVAGKIVPAMCTSTAVVSG 853  Schizosaccharomyc...
BAB19785  825 IFQLEKAILSNEATKSd-LQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSG 903  human
AAB39246  855 IDDLIAKIDQCRHNLSpdFRMKPIQFEKDDDTNYHMDVIAGLANMRARNYSIPEVDKLKAKFIAGRIIPAIATSTAMATG 934  thale cress
4II2_A    854 LVCLELVKLVDGkKKIEEYKNGFFNLAIGLFTFSDPIASPKMKVNGKEIDkIWDRYNLP---DCTLQELIDYFQkEEGLE 930  Schizosaccharomyc...
BAB19785  904 LVALEMIKVTGG-YPFEVYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFtIWDRWTVHgkeDFTLLDFINAVKeKYGIE 982  human
AAB39246  935 LVCLELYKVLDGgHKVEAYRNTFANLALPLFSMAEPLPPKVVKHRDMAWT-VWDRWVLKg--NPTLREVLQWLE-DKGLS 1010 thale cress
4II2_A    931 VTMLSSGVSLLYANFQPpkKLAERLPLKISELVEQITKKKLepfrKHLVLEICCDDANGEDVEVPFICIK 1000 Schizosaccharomyces pombe 9...
BAB19785  983 PTMVVQGVKMLYVPVMP--GHAKRLKLTMHKLVKPTTEKKY----VDLTVSFAPDIDGDEDLPGPPVRYY 1046 human
AAB39246 1011 AYSISCGSCLLFNSMFT--RHKERMDKKVVDLARDVAKVELppyrNHLDVVVACEDEDDNDVDIPLVSIY 1078 thale cress
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