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Stein E, Clarke JO, Hutfless S, et al. Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 110 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 May. (Future Research Needs Papers, No. 27.)
Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 110 [Internet].
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| Topic | Stakeholder 1 | Stakeholder 2 | Stakeholder 3 | Stakeholder 4 | Stakeholder 5 | Stakeholder 6 | Stakeholder 7 | Stakeholder 8 | Stakeholder 9 | Sum (highest sum = highest priority) | Priority Rank (1 = highest priority) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| List 1: Clinical Research The individual stakeholder ratings have been inverted so that the highest value (6) is the highest priority. | |||||||||||
| Top Tier | |||||||||||
| 1. Comparative effectiveness of managing with WMC (gastric dysmotility/gastroparesis) | 6 | 4 | 6 | 4 | 6 | 26 | 1 | ||||
| 2. Comparative diagnostic accuracy and safety (gastric dysmotility/gastroparesis) | 4 | 6 | 4 | 4 | 5 | 23 | 2 | ||||
| 3. Gold standard (gastric dysmotility/gastroparesis) | 1 | 6 | 6 | 6 | 19 | 3 | |||||
| 4. Comparison of WMC and scintigraphy results (gastroparesis) | 6 | 4 | 3 | 5 | 18 | 4 | |||||
| 5. Gold standard (colonic dysmotility/slow-transit constipation) | 5 | 5 | 4 | 14 | 5 | ||||||
| 6. Reproducibility of WMC results (gastroparesis) | 5 | 2 | 4 | 3 | 14 | 5 | |||||
| 7. Comparative diagnostic accuracy and safety (colonic dysmotility/slow-transit constipation) | 5 | 5 | 1 | 11 | 6 | ||||||
| 8. Incremental diagnostic accuracy (gastric dysmotility/gastroparesis) | 3 | 2 | 5 | 10 | 7 | ||||||
| 9. Incremental diagnostic accuracy (colonic dysmotility/slow-transit constipation) | 2 | 1 | 6 | 9 | 8 | ||||||
| Other Gaps | |||||||||||
| 10. Distinction of subtypes of gastroparesis (gastric dysmotility/gastroparesis) | 1 | 2 | 4 | 7 | 9 | ||||||
| 11. Best test or combination for predicting outcomes after colectomy (colonic dysmotility/slow-transit constipation) | 5 | 2 | 7 | 9 | |||||||
| 12. Comparative accuracy in predicting response to treatment (colonic dysmotility/slow-transit constipation) | 3 | 3 | 1 | 7 | 9 | ||||||
| 13. Utility of colonic pressure (colonic dysmotility) | 1 | 1 | 2 | 1 | 5 | 10 | |||||
| 14. Differentiating IBS-C from idiopathic constipation (colonic dysmotility/slow-transit constipation) | 2 | 3 | 5 | 10 | |||||||
| 15. Comparisons of WMC pressure profiles (gastroparesis) | 2 | 3 | 5 | 10 | |||||||
| 16. Best test or combination for predicting outcomes without colectomy (colonic dysmotility/slow-transit constipation) | 3 | 1 | 4 | 11 | |||||||
| 17. Comparative accuracy in predicting response to treatment (gastric dysmotility/gastroparesis) | 2 | 2 | 12 | ||||||||
| 18. Comparative value in monitoring response to treatment (gastric dysmotility/gastroparesis) | 0 | 13 | |||||||||
| 19. Comparative value in monitoring response to treatment (colonic dysmotility/slow-transit constipation) | 0 | 13 | |||||||||
| 20. Colonic pressure patterns after waking (colonic dysmotility) | 0 | 13 | |||||||||
| 21. Evaluation of high-amplitude contractions (colonic dysmotility) | 0 | 13 | |||||||||
| List 2: Questions Involving Methodological Research | |||||||||||
| Top Tier | |||||||||||
| 1. WMC data in patients with gastric and colonic dysmotility* | 3 | 6 | 5 | 7 | 6 | 7 | 6 | 6 | 1 | 47 | 1 |
| 2. WMC data in non-diseased populations* | 2 | 7 | 4 | 7 | 4 | 7 | 7 | 2 | 40 | 2 | |
| 3. Rates of test failures and need for additional tests* | 6 | 6 | 5 | 5 | 4 | 3 | 5 | 34 | 3 | ||
| 4. WMC diagnostic accuracy and safety in gastroparesis subtypes* | 7 | 4 | 3 | 4 | 5 | 1 | 5 | 29 | 4 | ||
| 5. Thresholds* | 5 | 7 | 3 | 6 | 5 | 1 | 27 | 5 | |||
| 6. Correlation between WMC values and histopathology* | 6 | 1 | 4 | 7 | 18 | 6 | |||||
| Other Gaps | |||||||||||
| 7. Colonic pressure patterns following meal ingestion. | 5 | 2 | 4 | 1 | 3 | 15 | 7 | ||||
| 8. Relation of baseline WMC values with long-term followup values | 1 | 3 | 3 | 6 | 13 | 8 | |||||
| 9. WMC data compared with other tests in non-diseased populations | 4 | 3 | 2 | 3 | 12 | 9 | |||||
| 10. Concurrent tests | 1 | 2 | 2 | 4 | 9 | 10 | |||||
| 11. Masking interpreters of WMC data | 1 | 2 | 2 | 5 | 11 | ||||||
| 12. Use of historical controls in WMC research | 2 | 2 | 12 | ||||||||
C = clinical knowledge gap; M = methodological knowledge gap; WMC = wireless motility capsule.
- Individual Stakeholder Priority Scores for Future Research Questions - Wireless ...Individual Stakeholder Priority Scores for Future Research Questions - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs
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