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Gutman SI, Oliansky DM, Belinson S, et al. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 98 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Apr. (Future Research Needs Papers, No. 24.)
PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 98 [Internet].
Show detailsTable F.1Results from PCA3 future research needs prioritization survey
| Rank | Research need | Total votes | Total Score |
|---|---|---|---|
| 1 | Lack of information on the comparative performance of PCA3 and currently used biomarkers to detect prostate cancer; lack of “matched studies” on comparators | 4 | 11 |
| 2 | Lack of studies on how PCA3 actually helps in treatment decisionmaking | 4 | 8 |
| 3 | Lack of information on the impact of PCA3 on short term outcomes such as biopsy decisionmaking | 4 | 7 |
| 4 | Uncertainty of impact of PCA3 in biopsy decisionmaking on long-term health outcomes | 3 | 6 |
| 5 | Lack of a definition of “clinically significant improvement” in diagnostic accuracy | 2 | 5 |
| 6 | Potential for comparisons of PCA3 with tPSA to be affected by inadequate clinical characterization of populations studied (e.g. verification bias) | 3 | 4 |
| 6 | Lack of clear endpoint to establish performance; when PCA3 disagrees with other inclusion criteria how do you know which is right? | 2 | 4 |
| 7 | Lack of information on the impact of PCA3 in treatment decisionmaking on long-term health outcomes | 2 | 3 |
| 8 | Lack of information on how demographics impact PCA3 test | 0 | 0 |
- Results From PCA3 Research Needs Prioritization Survey - PCA3 Testing in the Dia...Results From PCA3 Research Needs Prioritization Survey - PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs
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