Effective Health Care Program Selection Criteria

Appropriateness

• Represents a health care drug, intervention, device, technology or health care system/setting available (or soon to be available) in the United States.
• Relevant to 1013 enrollees (Medicare, Medicaid, S-CHIP, other federal health care programs.
• Represents one of the priority conditions designated by the U.S. Department of Health and Human Services (HHS).

Importance

• Represents a significant disease burden, large proportion or priority population.
• Is of high public interest; affects health care decision-making, outcomes, or costs for a large proportion of the U.S. population or for a priority population in particular.
• Was nominated/strongly supported by one or more stakeholder groups.
• Represents important uncertainty for decisionmakers.
• Incorporates issues around both clinical benefits and potential clinical harms.
• Represents important variation in clinical care, or controversy in what constitutes appropriate clinical care.
• Represent high costs to consumers, patients, health care systems or payers; due to common use, high unit costs, or high associated costs.

Desirability of New Research/Duplication

• Would not be redundant (i.e., the proposed topic is not already covered by available or soon-to-be available evidence.)

Feasibility

• Effectively uses existing research and knowledge by considering adequacy of research for conducting research, and newly available evidence

Potential Impact

• Potential for significant health impact, significant economic impact, potential change, potential risk from inaction, addressing inequities and vulnerable populations, and/or addressing a topic with clear implications for resolving important dilemmas in health and health care decisions made by one or more stakeholder groups.

Literature Search Strategy

Databases: Ovid MEDLINE, MEDLINE(R) In-Process, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register (CCTR)

Search conducted: 1/13/2012

Table A1

Literature search terms organize.

Yield of Ongoing Studies

Table A2

Ongoing research on SMBP identified through ClinicalTrials.gov.