Table 4Expression of anti-apoptotic proteins in TLE brain tissue

Increased
  1. Bcl-2, Bcl-xL* and Bcl-w (hippocampus or neocortex)
  2. Akt phosphorylation (hippocampus)
  3. X-linked IAP binding to caspase-7 (hippocampus)
Decreased
  1. MDM2 (p53 negative regulator)
*

Bcl-xL was increased in neocortex but not in hippocampus

From: Cell death and survival mechanisms after single and repeated brief seizures

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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