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Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

  • This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

Cover of Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

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Figure 4. Reconnecting the granule cell network.

Figure 4Reconnecting the granule cell network

In temporal lobe epilepsy, granule cells in the dentate gyrus sprout axon collaterals that synapse onto other granule cells, creating a recurrent excitatory circuit. A: In the control network, connections were modeled as random, constrained only by the extent of the granule cells’ axonal arbors.17 B: In theFPI network model, the same total number of connections are introduced, but the connectivity is different. A few cells are highly connected, while the rest remain sparsely connected. Note that the experimental network depicted here is only a visual guide to understanding the general connectivity of the network.

From: Computer Modeling of Epilepsy

Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

All Jasper's Basic Mechanisms of the Epilepsies content, except where otherwise noted, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported license, which permits copying, distribution and transmission of the work, provided the original work is properly cited, not used for commercial purposes, nor is altered or transformed.

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