| Study | Sensitivity (% True Positives) | % False Positives (1 Minus Specificity) | ||||
|---|---|---|---|---|---|---|
| Toxin Gene Test | Toxin Immunoassay | % Difference | Toxin Gene Test | Toxin Immunoassay | % Difference | |
| Kvach, 201037 Eastwood, 200932 Pooled Estimate heterogeneity† | GeneOhm, Becton Dickinson 96/105 (91%) 92/103 (89%) | Tox A/B II, TechLab 70/105 (67%) 100/125 (80%) | 25 (11 to 39)* 9 (-3 to 21) 17 (-3 to 37) p=0.03; I2=79% | GeneOhm, Becton Dickinson 0/295 (0%) 16/449 (3.6%) | Tox A/B II, TechLab 1/295 (0.3%) 19/475 (4.0%) | 0 (-4 to 3) 0 (-2 to 1) 0 (-1 to 1) p=0.90; I2=0% |
| Swindells, 2010165 Eastwood, 200932 Pooled Estimate heterogeneity† | GeneOhm, Becton Dickinson 17/18 (94.4%) 92/103 (89%) | VIDAS Clostridium difficile A and B, bioMerieux 8/18 (44.4%) 100/116 (86%) | 50 (17 to 83) 3 (-8 to 14) 25 (-36 to 86) p<0.001; I2=92% | GeneOhm, Becton Dickinson 1/132 (0.8%) 16/449 (3.6%) | VIDAS Clostridium difficile A and B, bioMerieux 0/132 (0%) 2/464 (0.4%) | 1 (-2 to 3) 3 (1 to 6) 2 (-1 to 5) p=0.07; I2=70% |
| Eastwood, 200932 | GeneOhm, Becton Dickinson 92/103 (89%) | Premier Toxin A&B, Meridian 101/125 (81%) | 9 (-3 to 21) | GeneOhm, Becton Dickinson 16/449 (3.6%) | Premier Toxin A&B, Meridian 12/475 (2.5%) | 1 (-2 to 4) |
| Eastwood, 200932 | GeneOhm, Becton Dickinson 92/103 (89%) | ImmunoCard A&B, Meridian 86/115 (75%) | 15 (1 to 28) | GeneOhm, Becton Dickinson 16/449 (3.6%) | ImmunoCard Toxin A&B, Meridian 2/444 (0.4%) | 3 (1 to 6) |
| Eastwood, 200932 | GeneOhm, Becton Dickinson 92/103 (89%) | Tox A/B QUIK CHEK, TechLab 93/125 (74%) | 15 (2 to 28) | GeneOhm, Becton Dickinson 16/449 (3.6%) | Tox A/B QUIK CHEK, TechLab 3/473 (0.6%) | 3 (0 to 5) |
| Eastwood, 200932 | GeneOhm, Becton Dickinson 92/103 (89%) | ProSpecT Toxin A/B, Remel 102/125 (82%) | 8 (-4 to 20) | GeneOhm, Becton Dickinson 16/449 (3.6%) | ProSpecT Toxin A/B, Remel 32/475 (6.7%) | -3 (-7 to 1) |
| Eastwood, 200932 | GeneOhm, Becton Dickinson 92/103 (89%) | Xpect Toxin A/B, Remel 86/117 (74%) | 16 (3 to 29) | GeneOhm, Becton Dickinson 16/449 (3.6%) | Xpect Toxin A/B, Remel 3/475 (0.6%) | 3 (0 to 5) |
| Swindells 2010165 | GeneXpert, Cepheid 18/18 (100%) | VIDAS Clostridium difficile A and B, bioMerieux 8/18 (44.4%) | 56 (25 to 86) | GeneXpert, Cepheid 1/132 (0.8%) | VIDAS Clostridium difficile A and B, bioMerieux 0/132 (0%) | 1 (-1 to 3) |
| Novak-Weekly, 201040 | GeneXpert, Cepheid 68/72 (94%) | Premier Toxin A&B, Meridian 42/72 (58%) | 36 (20 to 53) | GeneXpert, Cepheid 13/356 (3.7%) | Premier Toxin A&B, Meridian 19/360 (5.3%) | -2 (-6 to 2) |
Values in parentheses are 99% confidence intervals for the difference between tests conservatively assuming statistical independence between the paired tests.
The p-value is a chi-square test for nonrandom variation in the differences between studies, and I2 is the proportion of the total variance in the estimated differences that reflects true variation (i.e. heterogeneity between studies).
From: Results
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