Table 97, Summary of study characteristics for oral disulfiram - Alcohol-Use Disorders

	Oral disulfiram versus placebo	Oral disulfiram versus acamprosate	Oral disulfiram versus naltrexone	Oral disulfiram versus topiramate	Oral disulfiram + counselling versus counselling
Total number of trials (total number of participants)	3 RCTs (N = 859)	1 RCT (N = 243)	2 RCTs (N = 343)	1 RCT (N = 100)	1 RCT (N = 26)
Study ID	CHICK1992 FULLER1979 FULLER1986	LAAKSONEN2008	DESOUSA2004 LAAKSONEN2008	DESOUSA2008	GERREIN1973
Diagnosis	National Council on alcoholism diagnostic criteria or by an undefined diagnosis tool	ICD diagnosis of alcohol dependence	DSM or ICD diagnosis of alcohol dependence	DSM diagnosis of alcohol dependence	Undefined diagnosis tool
Baseline severity –units consumed per week	Mean: 198.5 Range: 190 to 207	Mean: 136.25	Mean: 111.35 Range: 86.45 to 136.25	Mean: 70	Not reported
Mean dosage	Disulfiram: 250 mg daily	Disulfiram: 150 mg daily Acamprosate: 1998 mg daily	Disulfiram: 200 mg daily Naltrexone: 50 mg daily	Disulfiram: 250 mg daily Topiramate: 150 mg daily	Disulfiram: 250 mg daily
Length of treatment	Range: 24 weeks – 52 weeks.	52 weeks	52 weeks	36 weeks	8 weeks
Length of follow-up	1–3. No follow-up data recorded	No follow-up data recorded	1–2. No follow-up data recorded	No follow-up data recorded	No follow-up data recorded
Setting	1–2. Outpatient 3. Inpatient/outpatient	Outpatient	1–2. Outpatient	Inpatient/outpatient	Outpatient
Treatment goal (if mentioned)	3. Abstinence	Abstinence	1–2. Abstinence	Abstinence	Not mentioned

Oral disulfiram versus placebo

Oral disulfiram versus acamprosate

Oral disulfiram versus naltrexone

Oral disulfiram versus topiramate

Oral disulfiram + counselling versus counselling

Total number of trials (total number of participants)

3 RCTs (N = 859)

1 RCT (N = 243)

2 RCTs (N = 343)

1 RCT (N = 100)

1 RCT (N = 26)

Study ID

LAAKSONEN2008

DESOUSA2008

GERREIN1973

Diagnosis

National Council on alcoholism diagnostic criteria or by an undefined diagnosis tool

ICD diagnosis of alcohol dependence

DSM or ICD diagnosis of alcohol dependence

DSM diagnosis of alcohol dependence

Undefined diagnosis tool

Baseline severity –units consumed per week

Mean: 198.5
Range: 190 to 207

Mean: 136.25

Mean: 111.35
Range: 86.45 to 136.25

Mean: 70

Not reported

Mean dosage

Disulfiram: 250 mg daily

Disulfiram: 150 mg daily

Acamprosate: 1998 mg daily

Disulfiram: 200 mg daily

Naltrexone: 50 mg daily

Disulfiram: 250 mg daily

Topiramate: 150 mg daily

Disulfiram: 250 mg daily

Length of treatment

Range: 24 weeks – 52 weeks.

52 weeks

36 weeks

8 weeks

Length of follow-up

1–3.: No follow-up data recorded

No follow-up data recorded

1–2.: No follow-up data recorded

No follow-up data recorded

No follow-up data recorded

Setting

1–2.: Outpatient
3.: Inpatient/outpatient

Outpatient

1–2.: Outpatient

Inpatient/outpatient

Outpatient

Treatment goal (if mentioned)

3.: Abstinence

Abstinence

1–2.: Abstinence

Abstinence

Not mentioned

From: 7, PHARMACOLOGICAL INTERVENTIONS

Alcohol-Use Disorders: Diagnosis, Assessment and Management of Harmful Drinking and Alcohol Dependence.

NICE Clinical Guidelines, No. 115.

National Collaborating Centre for Mental Health (UK).

Leicester (UK): British Psychological Society (UK); 2011.

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Table 97Summary of study characteristics for oral disulfiram