| Decreased vascular density |
| Heterogeneous distribution of microvessels |
| Increased presence of sinusoids, dead ends and arterio-venous anastomosis |
| Lack of arteriolar vessels |
| Decreased perfusional pressure and increased geometric resistance absence of lymphatics, increased TIF, hemoconcentration, increased viscosity |
| Incomplete basement membrane and absence of smooth muscle |
| Decreased stabilization for absence of pericytes and mural cells |
| Decreased leukocyte-endothelium adhesion |
| Absence of innervation and regulation according to metabolic demand |
From: Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications
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