Table 1

Clinical and haematologic manifestation of deletional and non-deletional forms of haemoglobin H (reproduced with permission from Guidelines for the Management of Non Transfusion Dependent Thalassaemia (NTDT), 2nd edition)

Clinical manifestationDeletional HbH diseaseNon-deletional HbH disease
Haemoglobin (g/L)85 (range 69 - 107)72 (range 38 – 87)
Mean corpuscular volume (MCV) (fl)54.0 (range 46.0 – 76.0)65.2 (range 48.7 – 80.7)
Mean corpuscular haemoglobin (MCH) (pg)16.6 (range 14.3 – 24.7)18.6 (range 14.8 – 24.8)
Reticulocytosis+++

From: Chapter 1, EPIDEMIOLOGY, PATHOPHYSIOLOGY AND DIAGNOSIS OF α-THALASSAEMIA

Cover of Guidelines for the Management of α-Thalassaemia
Guidelines for the Management of α-Thalassaemia [Internet].
Amid A, Lal A, Coates TD, et al., editors.
Nicosia (Cyprus): Thalassaemia International Federation; 2023.
© Thalassaemia International Federation.

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