Table 2Summary of included studies

StudyPopulationInterventionComparisonOutcomes

Biradar 2021

Randomised controlled trial

India

N= 320 women with singleton pregnancy who had a vaginal birth at 37-42 weeks

Women who received oxytocin in 1st stage of labour not excluded

3 units IV oxytocin bolus injection and 7 units oxytocin IV slow infusion following vaginal birth10 units IM oxytocin following vaginal birth
  • Need for additional uterotonics

Oladapo 2020

Cochrane systematic review

Ireland, Egypt, Turkey, Argentina, Mexico, Thailand

K= 7 (Adnan 2018, Charles 2019, Dagdeviren 2016, Durocher 2019, Neri-Mejia 2016, Oguz 2014, Sangkhomkhamhang 2015)

N= 7817 women with planned vaginal birth regardless of other aspects of third stage management

Women who received oxytocin in 1st stage of labour not excluded
  • 10 units IV oxytocin bolus injection following vaginal birth (K= 5)
  • 10 units IV oxytocin slow infusion following vaginal birth (K= 3)
10 units IM oxytocin following vaginal birth
  • Maternal admission to ITU or high-dependency area
  • Primary PPH
  • Severe PPH
  • Need for manual removal of placenta
  • Need for additional uterotonics
  • Side effects

IM: intramuscular; ITU: intensive therapy unit; IV: intravenous; PPH: postpartum haemorrhage

From: Evidence reviews for route of administration of oxytocin in the third stage of labour

Cover of Evidence reviews for route of administration of oxytocin in the third stage of labour
Evidence reviews for route of administration of oxytocin in the third stage of labour: Intrapartum care: Evidence review L.
NICE Guideline, No. 235.
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