Table 5Excluded studies and reasons for their exclusion

StudyReason
Adnan, Nita, Conlan-Trant, Rebecca, McCormick, Ciara et al. (2018) Intramuscular versus intravenous oxytocin to prevent postpartum haemorrhage at vaginal delivery: randomised controlled trial. BMJ (Clinical research ed.) 362: k3546 - Included as part of a systematic review
Akinaga, Chieko, Uchizaki, Sakiko, Kurita, Tadayoshi et al. (2016) Randomized doubleblind comparison of the effects of intramyometrial and intravenous oxytocin during elective cesarean section. The journal of obstetrics and gynaecology research 42(4): 404–9 [PubMed: 26786149]

- Population not in PICO

Population is women who have had elective caesarean birth

Ashwal, E., Hiersch, L., Wertheimer, A. et al. (2016) The effect of post-partum oxytocin regimen on hemoglobin decline-a randomized controlled trial. American journal of obstetrics and gynecology 214(1): S197–S198 - Conference abstract
Blum, J., Durocher, J., Trussell, J. et al. (2011) How effective are the components of active management of the third stage of labor?. Contraception 84(3): 336 - Conference abstract
Carroli, G., Durocher, J., Dzuba, I. et al. (2018) Does route matter? intravenous versus intramuscular oxytocin for prevention of postpartum hemorrhage. International journal of gynaecology and obstetrics 143: 236 - Conference abstract.
Charles, Dyanna, Anger, Holly, Dabash, Rasha et al. (2019) Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial. BMC pregnancy and childbirth 19(1): 38 [PubMed: 30658605] - Included as part of a systematic review
Dagdeviren, Hediye, Cengiz, Huseyin, Heydarova, Ulkar et al. (2016) Intramuscular versus intravenous prophylactic oxytocin for postpartum hemorrhage after vaginal delivery: a randomized controlled study. Archives of gynecology and obstetrics 294(5): 911–916 [PubMed: 26980230] - Included as part of a systematic review
Durocher, J., Blum, J., Sheldon, W. R. et al. (2012) Does the effect of oxytocin prophylaxis on post-partum blood loss depend on route of administration?. International journal of gynaecology and obstetrics 119: S332 - Conference abstract
Durocher, Jill, Dzuba, Ilana G., Carroli, Guillermo et al. (2019) Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial. PloS one 14(10): e0222981 [PubMed: 31574114] - Included as part of a systematic review
Ebada, Mahmoud Ahmed; Elmatboly, Abdelmagid M.; Baligh, Galal (2020) Intravenous Oxytocin versus Intramuscular Oxytocin for the Management of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis. Current drug research reviews 12(2): 150–157 [PubMed: 32600245] - Systematic review- more recent systematic review included
Leduc, Dean, Senikas, Vyta, Lalonde, Andre B. et al. (2009) Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage. Journal of obstetrics and gynaecology Canada : JOGC = Journal d’obstetrique et gynecologie du Canada : JOGC 31(10): 980–993 - Narrative review
Neri-Mejía, M. and Pedraza-Avilés, A. G. (2016) Active management of the third stage of labor: three schemes of oxytocin: randomised clinical trial. Ginecologia y obstetricia de Mexico 84(5): 306–313 [PubMed: 27476252] - Included as part of a systematic review
Oguz Orhan, E., Dilbaz, B., Aksakal, S. E. et al. (2014) Prospective randomized trial of oxytocin administration for active management of the third stage of labor. International journal of gynaecology and obstetrics 127(2): 175–179 [PubMed: 25108586] - Included as part of a systematic review
Oladapo, Olufemi T.; Okusanya, Babasola O.; Abalos, Edgardo (2018) Intramuscular versus intravenous prophylactic oxytocin for the third stage of labour. The Cochrane database of systematic reviews 9: cd009332 [PubMed: 30246877] - Systematic review- more recent systematic review included
Paikhomba Singh, K.; Kameshore, N.; Kamei, H. (2015) Prophylactic intramuscular injection of oxytocin vs intravenous infusion of oxytocin to minimise blood loss at caesarean section. International Journal of Gynecology and Obstetrics 131(suppl5): e290 - Conference abstract
Sangkomkamhang, U. and Kruangpatee, A. (2015) A randomised controlled trial of intravenous versus intramuscular oxytocin in the prevention of postpartum hemorrhage during the third stage of labor. Journal of health science 24(2): 354–359 - Included as part of a systematic review
Westhoff, Gina; Cotter, Amanda M.; Tolosa, Jorge E. (2013) Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. The Cochrane database of systematic reviews: cd001808 - Comparator not in PICO Systematic review comparing oxytocin to no uterotonics or other uterotonics
Wu, Yu, Wang, Huan, Wu, Qi-Yan et al. (2020) A meta-analysis of the effects of intramuscular and intravenous injection of oxytocin on the third stage of labor. Archives of gynecology and obstetrics 301(3): 643–653 [PubMed: 32124015] - Systematic review- systematic review with more relevant outcomes included
Zhou, Yuan-Hong, Xie, Yan, Luo, You-Zhen et al. (2020) Intramuscular versus intravenous oxytocin for the third stage of labor after vaginal delivery to prevent postpartum hemorrhage: a meta-analysis of randomized controlled trials. European journal of obstetrics, gynecology, and reproductive biology 250: 265–271 [PubMed: 32439242] - Systematic review- more recent systematic review included

From: Evidence reviews for route of administration of oxytocin in the third stage of labour

Cover of Evidence reviews for route of administration of oxytocin in the third stage of labour
Evidence reviews for route of administration of oxytocin in the third stage of labour: Intrapartum care: Evidence review L.
NICE Guideline, No. 235.
Copyright © NICE 2023.

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