| Endpoint | Test System | Doses/Concentrations Tested (μg/plate) | Results without Activation | Results with Activation | Comments | References |
|---|---|---|---|---|---|---|
| Genotoxicity studies in prokaryotic organisms | ||||||
| Mutation | Salmonella typhimurium strains TA98, TA100 | 0, 17, 34, 68, 135, 270 | + | + | Plate incorporation assay. 3,5-Dinitroaniline induced a doubling of the spontaneous mutation rate at ≥34 μg/plate in TA98 and ≥17 μg/plate in TA100. | Assmann et al. (1997) |
| Mutation | S. typhimurium strains TA98, TA100, TA1535, TA1537, TA1538, TA100NR3 (nitroreductase-deficient strain) | 0, 0.5–40 |
+ TA98, TA100, TA1535, TA1537, TA1538 − TA100NR3 |
+ TA1535 − TA98, TA100, TA1537, TA1538, TA100NR3 | Plate incorporation assay. Effective dose(s) were not reported. | Spanggord et al. (1982) |
From: 2, REVIEW OF POTENTIALLY RELEVANT DATA (NONCANCER AND CANCER)
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