Table 2Organ Weights Summarya

Endpoint0 mg/kgb,c
n = 4		61 mg/kg
n = 3		123 mg/kg
n = 4		245 mg/kg
n = 5		489 mg/kg
n = 4		979 mg/kg
n = 3		BMD1Std
(mg/kg)		BMDL1Std
(mg/kg)
Terminal Body Weight (g)272.2 ± 0.4*275.5 ± 6.9274.1 ± 7.8270.2 ± 6.1247.1 ± 6.7*258.0 ± 5.2NVMNVM
Brain Weight Relatived (mg/g)6.14 ± 0.26**6.53 ± 0.116.44 ± 0.206.64 ± 0.167.19 ± 0.23**6.76 ± 0.17**123.743.3
Liver Weight Relative (mg/g)38.21 ± 1.15**42.34 ± 2.4645.20 ± 0.76**45.70 ± 1.68**48.20 ± 0.75**47.54 ± 2.86**39.417.2

Statistical significance for a dosed group indicates a significant pairwise test compared to the vehicle control group. Statistical significance for the vehicle control group indicates a significant trend test.

*

Statistically significant at p ≤ 0.05; **p ≤ 0.01.

Benchmark response set at 1 standard deviation from the mean.

BMD = benchmark dose; BMDL = benchmark dose lower confidence limit; NVM = nonviable model.

a

Descriptions of organ weight endpoints and changes are provided in Appendix E.

b

Data are displayed as mean ± standard error of the mean.

c

Statistical analysis performed by the Jonckheere (trend) and Williams or Dunnett (pairwise) tests.

d

Relative organ weights (organ weight-to-body weight ratios) are given as mg organ weight/g body weight.

From: NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)

Cover of NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)
NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): NIEHS Report 02 [Internet].
Auerbach SS, Behl MV, Collins BJ, et al.
Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2022 Oct.
Copyright Notice

This is a work of the US government and distributed under the terms of the Public Domain

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.