Fig. 2. Hypertrophy and inflammation in adipose tissues cause dyslipidemia and promote atherosclerosis.

Fig. 2

Hypertrophy and inflammation in adipose tissues cause dyslipidemia and promote atherosclerosis. Chronic caloric surplus and low energy expenditure result in obesity, which is characterized by inflamed (indicated by red-colored immune cells) and hypertrophic adipose tissues as well as dysfunctional brown adipose tissues. Eventually, this causes atherogenic dyslipidemia due to impaired TRL clearance and enhanced fatty acid flux to the liver leading to increased lipoprotein secretion. The lower release of adipocyte-derived anti-inflammatory molecules (see Fig. 1) and pro-inflammatory cytokines in particular those released by PVAT promote inflammation and vasoconstriction. Overall, this creates an immunometabolic state that promotes atherosclerotic plaque formation

From: Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis

Cover of Prevention and Treatment of Atherosclerosis
Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets [Internet].
von Eckardstein A, Binder CJ, editors.
Cham (CH): Springer; 2022.
Copyright 2020, The Author(s)

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